Prevalence and trends of hepatitis C virus among blood donors in Antananarivo, from 2003 to 2009

Randriamanantany, Zely Arivelo; Rajaonatahina, Davidra; Razafimanantsoa, Fetralinjiva; Rasamindrakotroka, M.T.; Andriamahenina, R.; Rasoarilalaomanarivo, F.B.; Hanitriniala, S. P.; Herisoa, F.R.; Rakoto-Alson, Olivat A.; Rasamindrakotroka, A.

doi:10.1016/j.tracli.2011.10.004

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…The range of prevalence across articles was between 1.0% and 4.0%. The majority (7/10) of the articles reported HCV prevalence between 0.0% and 1.0%, 17,18,20,22–24,29 but three articles reported prevalence between 3.2% and 3.9% 15,16,26 . Of the articles that reported higher HCV prevalence, two were from DRC and one was from Tanzania.…”

Section: Resultsmentioning

confidence: 98%

Systematic review of prevalence and risk factors of transfusion transmissible infections among blood donors, and blood safety improvements in Southern Africa

Puerto‐Meredith,

Singogo,

Chagomerana

et al. 2023

Transfusion Medicine

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Blood and blood products are listed as one of the essential medicines by the World Health Organization (WHO). In addition to inadequate supply, most sub‐Saharan Africa (SSA) nations fail to meet their blood needs because many donated blood units are discarded because they are contaminated with transfusion‐transmitted infections (TTIs). We sought to estimate the prevalence of TTIs, identify the risk factors for TTIs among blood donors, and identify the efforts and interventions that have been made to improve blood safety in Southern African nations, particularly the nations of the South African Development Community (SADC). We investigated the prevalence and risk factors for TTIs, blood safety interventions, and blood quality improvement in the SADC region from major PubMed/MEDLINE, Cochrane Library, and HINARI databases from 1 January 2011 to 31 April 2021. All investigations followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA). In meta‐analysis, we estimated the pooled TTIs prevalence and summarised the same using forest plots. A total of 180 articles published from the SSA region were identified covering our three targeted themes: TTI prevalence, risk factors for TTIs, and blood safety improvements. Of these 180 articles, only 27 (15%) focused on the SADC region. The overall pooled TTI prevalence estimate was 2.0% (95% CI: 1.0–3.0) and hepatitis B was the most prevalent TTI in the region (prevalence = 3.0; 95% CI: 2.0–5.0). The prevalence of HIV, HCV, and syphilis was 2.0% (95% CI: 1.0–4.0), 1.0% (95% CI: 0.0–2.0), and 2.0% (95% CI: 0.0–8.0), respectively. In general, replacement donors and first‐time donors were more likely to be infected with TTIs than repeat donors. Twelve articles explored blood safety research in the region; however, they vary greatly highlighting the need for consistent and more comprehensive research. Few publications were identified that were from the SADC region, indicating lack of research or resources towards improving both quantity and quality of blood donation. TTI prevalence remains one of the highest in the world and blood safety recommendations vary across the region. More effort should be directed towards developing a cohesive regional blood transfusion policy and effective blood monitoring and evaluation strategies.

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Section: Resultsmentioning

confidence: 98%

Systematic review of prevalence and risk factors of transfusion transmissible infections among blood donors, and blood safety improvements in Southern Africa

Puerto‐Meredith,

Singogo,

Chagomerana

et al. 2023

Transfusion Medicine

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“…La séroprévalence du VHC avait une tendance légèrement augmentée au fil des années. Une élévation de la prévalence a été trouvée par rapport à une étude fait en 2003 jusqu'en 2009, parce que la sélection des donneurs s'est surtout développée après le passage du croix rouge de Belgique en 2007 [20]. La séroprévalence du VHC est élevée par rapport aux autres pays comme l'Ethiopie, le Mexique où elle est de 0,7% et 0,79% respectivement [9,6].…”

Section: Discussionunclassified

Séroprévalence du VIH, VHB, VHC et de Treponema pallidum chez les donneurs du sang bénévoles au Centre National de Transfusion Sanguine d’Antananarivo de 1992 à 2010

Rakotoniaina,

Randriamanantany,

Ranaivosoa

et al. 2013

Rev méd Madag

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Introduction. To determine the seroprevalence of HIV, HBV, HCV and Treponema pallidum in voluntary blood donors. Materials and methods. A retrospective study was conducted during an 18 years period (1998-2010) at the National Center of Blood Trans- fusion, Antananarivo. Results. 5504 donors were included, 5.85% (322) had at least one positive serology regarding the four microorganisms. Seroprevalence of HIV, hepatitis B virus, hepatitis C virus and Treponema pallidum was 0.47% (n=26), 3.21% (n=177) and 0.98% (n=54), 1.18 % (n=65) respec- tively. Hepatitis B virus was more prevalent in male. Conclusion. At the National Blood Transfusion Center of Antananarivo the seroprevalence of HIV, hepatitis B virus, hepatitis C virus and Treponema pallidum is lower than in general population. The increase in HIV seroprevalence must improve screening methods such as de- tecting AgP24 rapids tests and even PCR.

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Prévalence de la co-infection par le virus de l’immunodéficience humaine et les virus de l’hépatite B et de l’hépatite C : étude multicentrique à Madagascar

Rakotozafindrabe

Andriamifidison²,

Rabenjanahary

et al. 2016

J Afr Hepato Gastroenterol

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Prevalence and trends of hepatitis C virus among blood donors in Antananarivo, from 2003 to 2009

Cited by 3 publications

References 33 publications

Systematic review of prevalence and risk factors of transfusion transmissible infections among blood donors, and blood safety improvements in Southern Africa

Systematic review of prevalence and risk factors of transfusion transmissible infections among blood donors, and blood safety improvements in Southern Africa

Séroprévalence du VIH, VHB, VHC et de Treponema pallidum chez les donneurs du sang bénévoles au Centre National de Transfusion Sanguine d’Antananarivo de 1992 à 2010

Prévalence de la co-infection par le virus de l’immunodéficience humaine et les virus de l’hépatite B et de l’hépatite C : étude multicentrique à Madagascar

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