Prevalence and trends of transfusion-transmitted infections among blood donors in Tehran, Iran from 2008 to 2013

Keshvari, Maryam; Sharafi, Heidar; Alavian, Seyed Moayed; Mehrabadi, Haleh; Zolfaghari, Sima

doi:10.1016/j.transci.2015.03.003

Cited by 19 publications

(17 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hopefully the decline to 0.9% the following year will be a sustained downward trend in infection rate of the blood donors. The pattern of trend is in contrast to the decrease followed by a stable prevalence rate observed among Iranian blood donors [42]. Increasing trend for syphilis infection has been reported in blood donors in Pakistan [43].…”

Section: Discussionmentioning

confidence: 90%

A Seven Year Review of the Seroprevalence of Transfusion Transmitted Infections in a Hospital Based Blood Bank in Ibadan, Nigeria

Fasola¹

2017

CMR

View full text Add to dashboard Cite

Africa has the highest prevalence of transfusion transmitted infections. The World Health Organization recommends universal and quality-controlled screening of blood donations for the major transfusion-transmissible infections (TTIs): human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis. Therefore a retrospective study was conducted to assess the effect of strategies in our blood bank to improve blood safety on the seroprevalence of HIV, HCV, HBV and syphilis infections among the donors over a seven year period. Existing data in the blood bank was used to determine number of the blood donors who were infected with HIV, HCV, HBV and syphilis. The test methods used to screen the donors were identified. The trend of prevalence of the transfusion transmitted infections among the blood donors from 2009 to 2015 was also determine. A total of 41,445 blood donors were screened. Voluntary blood donors constituted 11.1% of the donor population. The overall seroprevalence rate for the TTI was 12.3%. The prevalence was highest for HBV (8.5%) followed by HIV (1.8%), HCV (1.4%) and least for syphilis (0.5%) respectively. The infections showed significant inter-year variation (p<.001). A decreasing trend was observed for HBV among the blood donors while increase in prevalence of HIV, HCV and syphilis was observed from 2012 to 2014 and decreased in 2015. The prevalence of syphilis has risen from 0% in 2009 to 0.9% in 2015. The seroprevalence for TTI is high but is less compared to report from a previous study in same blood bank. The increasing infection rate for syphilis and sporadic surges in rates for HIV, HCV may suggest that the selection criteria is not effectively eliminating blood donors with risky lifestyle. There is need to educate the blood donors on avoiding risky lifestyle while also intensifying voluntary blood donor motivation strategy and increase community surveillance of the infections.

show abstract

Section: Discussionmentioning

confidence: 90%

A Seven Year Review of the Seroprevalence of Transfusion Transmitted Infections in a Hospital Based Blood Bank in Ibadan, Nigeria

Fasola¹

2017

CMR

View full text Add to dashboard Cite

show abstract

“…The decreasing trend of HBV incidence has also been reported in previous studies; in Hamadan province the decrease in HBV incidence was reported from 2004 to 2009 (19.6 to 7.70) (8). Moreover, in studies conducted among blood donors in the Islamic Republic of Iran, the decline in the frequency of HBV infection has been reported (15)(16)(17). However, contrary to these results, Khazaei et al (2018) showed an increase in HBV incidence from 2008 to 2013 in Ilam province (7).…”

Section: Discussionmentioning

confidence: 98%

Estimating the incidence rate of hepatitis B and C in East Azerbaijan, Islamic Republic of Iran

Somi

Khayatzadeh

Nalbandy

et al. 2020

East Mediterr Health J

View full text Add to dashboard Cite

Background: The World Health Organization (WHO) has aimed for a 30% reduction in hepatitis B (HBV) and hepatitis C (HCV) incidence by 2020. To achieve this goal, it is important to have updated information about trends in the hepatitis incidence rate. However, there is a lack of up-to-date data from East Azerbaijan province in the Islamic Republic of Iran.Aims: This study aimed to estimate the HBV and HCV incidence rate from 2011 to 2016 in East Azerbaijan, Islamic Republic of Iran.Methods: Hepatitis data and population data were obtained respectively from the national notifiable disease surveillance system and the national Iranian census for 2016. For quantifying the rate of changes in incidence rate from baseline, the average annual rate of reduction (AARR) was calculated. For this, the linear regression model was used for estimating the beta coefficient. SPSS V25 was used for statistical analysis.Results: Over the 6-year period, 3119 hepatitis cases in East Azerbaijan province were reported, of which 94.7% were hepatitis B. The majority of the affected individuals were 25-44 years old. HBV incidence was reduced by 12.71% annually between 2011 and 2016. However, the number of HCV patients increased during 2014-2016, and HCV incidence rate increased insignificantly (β = 0.109, P = 0.39).Conclusion: There is a significant downward trend of HBV in East Azerbaijan due to mass vaccination programmes. In the case of HCV, when considering the availability of effective treatment regimens in addition to education and prevention programmes, policy-makers should focus on HCV screening and diagnosis, especially in the 25-44 age group.

show abstract

“…HCV is most commonly transmitted through direct contact with blood as in blood transfusion (3). Screening of donated bloods for hepatitis C has been implemented in blood transfusion services since 1990s in most Middle Eastern countries (4). The post-transfusion hepatitis C has been a main cause of mortality and morbidity in poly-transfused patients such as patients with thalassemia and hemophilia in Middle Eastern countries (5).…”

Section: Contextmentioning

confidence: 99%

Seroprevalence of Hepatitis C Virus among Blood Donors in Middle Eastern Countries: A Systematic Review and Meta-Analysis

Ghaderi-Zefrehi

Sharafi

Sadeghi

et al. 2017

Iran Red Crescent Med J

Self Cite

View full text Add to dashboard Cite

Context: Hepatitis C virus (HCV) has been the main cause of post transfusion hepatitis. Long-term hepatitis can ultimately result in cirrhosis and hepatocellular carcinoma. Viral hepatitis, especially HCV infection, is a major health concern in the Middle East. The current study carried out a systematic search concerning HCV seroprevalence among blood donors in Middle Eastern countries. Evidence Acquisition: Articles were identified through searching databases including PubMed, Scopus, and Web of Science. We reviewed systematically all studies reporting HCV seroprevalence among blood donors in Middle Eastern countries. Results: A total of 5662 relevant records were identified by the electronic search, of which a total of 47 studies were identified as eligible papers that were meta-analyzed for the pooled seroprevalence of HCV among blood donors. Overall, HCV seroprevalence among blood donors in Middle Eastern countries was estimated 0.88% (95%CI = 0.79% -0.97%). The highest pooled HCV seroprevalence rate was related to Egypt (5.76% [95%CI = 3.30% -8.22%]), Libya (1.56% [95%CI = 0.99% -2.13%]), and Yemen (1.09% [95%CI = 0.69% -1.50%]) while the lowest pooled seroprevalence rate was in Iran and Israel with the rates of 0.14% (95%CI = 0.12% -0.17%) and 0.16% (95%CI = 0.06% -0.25%), respectively. Results of annual HCV seroprevalence suggest that there is a decrease in seroprevalence rate of HCV over time among blood donors in Egypt, Iran, Oman, Lebanon, Libya, and Saudi Arabia. Conclusions: Our results showed that the trend of HCV seroprevalence over time among Middle Eastern blood donors was decreasing. It suggests that recent safety measures implemented in Middle Eastern countries have been effective.

show abstract

Prevalence and trends of transfusion-transmitted infections among blood donors in Tehran, Iran from 2008 to 2013

Cited by 19 publications

References 20 publications

A Seven Year Review of the Seroprevalence of Transfusion Transmitted Infections in a Hospital Based Blood Bank in Ibadan, Nigeria

A Seven Year Review of the Seroprevalence of Transfusion Transmitted Infections in a Hospital Based Blood Bank in Ibadan, Nigeria

Estimating the incidence rate of hepatitis B and C in East Azerbaijan, Islamic Republic of Iran

Seroprevalence of Hepatitis C Virus among Blood Donors in Middle Eastern Countries: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About