Prevalence, clinical characteristics, and predictors of sleep disordered breathing in hospitalized heart failure patients

Huang, Boping; Huang, Yan; Zhai, Mei; Zhou, Qiong; Ji, Shiming; Liu, Huihui; Zhuang, Xiao-feng; Zhang, Yuhui; Zhang, Jian

doi:10.1002/clc.23925

Clinical Cardiology

2022

DOI: 10.1002/clc.23925

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Prevalence, clinical characteristics, and predictors of sleep disordered breathing in hospitalized heart failure patients

Boping Huang

Yan Huang

Mei Zhai

et al.

Abstract: Background: Heart failure (HF) is often comorbid with sleep disordered breathing (SDB). This prospective study investigated the prevalence, clinical characteristics, and predictors of SDB in hospitalized HF patients. Methods: Sleep studies were performed on hospitalized HF patients from January 2015 to February 2019. SDB was categorized as no/mild SDB, obstructive sleep apnea (OSA), and central sleep apnea (CSA).Results: The study included 1069 hospitalized HF patients. The prevalence rates of OSA and CSA were… Show more

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Cited by 3 publications

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“…Heart failure (HF) is a severe cardiovascular disease associated with a poor quality of life and a high medical burden and cost due to frequent hospitalizations and high mortality. 1 Sleep apnea is ubiquitous in HF, with more than half of hospitalized patients with HF having obstructive sleep apnea (OSA) or central sleep apnea (CSA), 2 and it is frequently underdiagnosed and undertreated.…”

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Association of Sex With Cardiovascular Outcomes in Heart Failure Patients With Obstructive or Central Sleep Apnea

Huang,

Zhai

et al. 2024

JAHA

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Background This study investigated the association of sex with cardiovascular outcomes in a prospective cohort of patients with heart failure (HF) with obstructive sleep apnea or central sleep apnea. Methods and Results Patients were screened for sleep apnea on admission using multichannel cardiopulmonary monitoring from May 2015 to July 2018. The primary outcome was a composite of cardiovascular death or unplanned hospitalization for worsening HF. Ultimately, 453 patients with HF with obstructive sleep apnea or central sleep apnea were included; 71 (15.7%) and 382 (84.3%) were women and men, respectively. During a median follow‐up of 2.33 years, 248 (54.7%) patients experienced the primary outcome. In the overall population, after adjusting for potential confounders, women had an increased risk of the primary outcome (66.2% versus 52.6%; hazard ratio [HR], 1.47 [95% CI, 1.05–2.04]; P =0.024) and HF rehospitalization (62.0% versus 46.6%; HR, 1.55 [95% CI, 1.10–2.19]; P =0.013) compared with men but a comparable risk of cardiovascular death (21.1% versus 23.3%; HR, 0.78 [95% CI, 0.44–1.37]; P =0.383). Likewise, in patients with HF with obstructive sleep apnea, women had a higher risk of the primary outcome (81.8% versus 46.3%, HR, 2.37 [95% CI, 1.28–4.38]; P =0.006) and HF rehospitalization (81.8% versus 44.7%, HR, 2.46 [95% CI, 1.32–4.56], P =0.004). However, in patients with HF with central sleep apnea, there was no statistically significant difference between women and men. Conclusions In hospitalized patients with HF, female sex was associated with an increased risk of the primary outcome and HF rehospitalization, especially in those with obstructive sleep apnea. Screening for sleep apnea should be emphasized to improve the prognosis. Registration URL: https://www.clinicaltrials.gov . Unique identifier: NCT02664818.

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mentioning

confidence: 99%

Association of Sex With Cardiovascular Outcomes in Heart Failure Patients With Obstructive or Central Sleep Apnea

Huang,

Zhai

et al. 2024

JAHA

Self Cite

View full text Add to dashboard Cite

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Prevalence, clinical characteristics, and predictors of sleep disordered breathing in hospitalized heart failure patients

Huang

Zhai

et al. 2022

Clinical Cardiology

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Background: Heart failure (HF) is often comorbid with sleep disordered breathing (SDB). This prospective study investigated the prevalence, clinical characteristics, and predictors of SDB in hospitalized HF patients. Methods: Sleep studies were performed on hospitalized HF patients from January 2015 to February 2019. SDB was categorized as no/mild SDB, obstructive sleep apnea (OSA), and central sleep apnea (CSA).Results: The study included 1069 hospitalized HF patients. The prevalence rates of OSA and CSA were 16.6% and 36.9%, respectively. Patients with OSA or CSA were more likely to be male and have a higher body mass index (BMI) and more comorbidities. Multivariate logistic regression analysis showed that male sex

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Approach the Patient With Obstructive Sleep Apnea and Obesity

Meyer,

Wittert

2023

The Journal of Clinical Endocrinology &Amp; Metabolism

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Obstructive sleep apnoea (OSA) and obesity are highly prevalent and bidirectionally associated. OSA is however underrecognized, particularly in women. By mechanisms that overlap with those of obesity, OSA increases the risk of developing, or having poor outcomes from, comorbid chronic disorders and impairs quality of life. Using two illustrative cases we discuss the relationships between OSA and obesity with type 2 diabetes, dyslipidemia, cardiovascular disease, cognitive disturbance, mood disorders, lower urinary tract symptoms, sexual function, and reproductive disorders. The differences in OSA between men and women, the phenotypic variability of OSA, and co-morbid sleep disorders are highlighted. When the probability of OSA is high due to consistent symptoms, comorbidities, or both, a diagnostic sleep study is advisable. Continuous positive airway pressure or mandibular advancement splints improve symptoms. Benefits for comorbidities are variable depending on nightly duration of use. By contrast weight loss and optimization of lifestyle behaviors are consistently beneficial.

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Prevalence, clinical characteristics, and predictors of sleep disordered breathing in hospitalized heart failure patients

Cited by 3 publications

References 30 publications

Association of Sex With Cardiovascular Outcomes in Heart Failure Patients With Obstructive or Central Sleep Apnea

Association of Sex With Cardiovascular Outcomes in Heart Failure Patients With Obstructive or Central Sleep Apnea

Prevalence, clinical characteristics, and predictors of sleep disordered breathing in hospitalized heart failure patients

Approach the Patient With Obstructive Sleep Apnea and Obesity

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