Prevalence, incidence and persistence of antipsychotic drug prescribing in the Italian general population: retrospective database analysis, 1999–2002

Mirandola, Mersia; Andretta, Margherita; Corbari, Letizia; Sorio, Adriano; Nosè, Michela; Barbui, Corrado

doi:10.1002/pds.1162

Cited by 32 publications

(36 citation statements)

References 46 publications

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“…A dramatic increase in the use of atypical agents in the general population, and particularly in elderly demented outpatients, starting from their marketing until 2002, was previously reported in Italy (Trifirò et al, 2005;Mirandola et al, 2006), as well as in UK and US (Ashcroft et al, 2002;Hermann et al, 2002). In Italy, thereafter, national statistics have shown that the increase in the use of atypicals slowed down after 2004, which is consistent with our findings and compatible with an effect of safety warnings.…”

Section: Discussionsupporting

confidence: 94%

Prescribing pattern of antipsychotic drugs in the Italian general population 2000–2005: a focus on elderly with dementia

Trifirò

Sini

Sturkenboom

et al. 2010

International Clinical Psychopharmacology

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The objective of this study was to evaluate the antipsychotic drug prescribing pattern in the Italian general population, elderly, and especially elderly with dementia, in relation to the safety warnings issued by international regulatory agencies about the risk of cerebrovascular adverse events and mortality in 2004 and 2005. A cohort study was conducted using the electronic medical records of the Italian general practice database 'Health Search/Thales'. On the basis of prescription data, 1-year and monthly prevalence estimates were calculated for atypical and typical antipsychotic use in general population, elderly, and elderly demented outpatients. One-year prevalence of individual medication use in elderly demented patients was calculated as well. The prevalence of use of atypical agents in demented patients progressively increased from 2000 [0.2 (0.05-0.7) per 10 000] until the beginning of 2004 [9.7 (8.1-11.6) per 10 000], after which a slight decrease started, whereas the prevalence of use of typical antipsychotics decreased from 2001 [15.7 (13.5-18.2) per 10 000] until 2004 [10.7 (9.0-12.7) per 10 000], then slightly increased in December 2005 [12.1 (10.4-14.2) per 10 000]. Monthly trends in general population and elderly were quite similar and differed significantly from the trend in elderly with dementia: stable use of atypicals from 2002 to 2005 and strong reduction of typicals from 2001 to the end of 2004. The recent safety warnings led to an increasing trend in the use of typical agents and decreasing trend in the use of atypical agents in elderly demented outpatients in Italy. Similar trends were not observed in general population and elderly as a whole.

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Section: Discussionsupporting

confidence: 94%

Prescribing pattern of antipsychotic drugs in the Italian general population 2000–2005: a focus on elderly with dementia

Trifirò

Sini

Sturkenboom

et al. 2010

International Clinical Psychopharmacology

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“…Such results were obtained in the ESEMeD project [11] and in more recent studies in Italy [20], Germany [21], France [22] and Switzerland [19]. In Swiss adult population, it was found that women have received benzodiazepine prescriptions in 67% cases, and half of all patients were at age 65 or older.…”

Section: Discussionsupporting

confidence: 66%

Dispensing of psychotropic drugs to adults in community pharmacies in Latvia

et al. 2008

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“…These studies were from Italy, [4][5][6] the United Kingdom, 7 and the United States. 8 The US study was found to be a case series concerned with phenothiazine and butyrophenone poisonings.…”

Section: Methodsmentioning

confidence: 99%

“…4 ; however, in the population studied, typical antipsychotics were used more frequently than atypical antipsychotics in each of the 4 years. This provided a stark contrast with the situation in some other countries, as described below.…”

Section: European Estimatesmentioning

confidence: 99%

A Review of Pharmacoepidemiologic Studies of Antipsychotic Use in Children and Adolescents

2012

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Objective: In Canada, treatment of children and adolescents with antipsychotics is almost always off label. A single atypical agent, aripiprazole, only recently received regulatory authorization for use in the group aged 15 to 17 years. This regulatory approval was restricted to treatment of schizophrenia. The objective of this review was to summarize pharmacoepidemiologic reports examining the frequency of use of these medications. Methods:A literature search was used to identify English-language studies examining the pharmacoepidemiology of antipsychotics in children and adolescents. The results of identified studies were summarized using narrative review methods. Results:In countries where longitudinal data are available, increased antipsychotic use has been consistently observed. Generally, most or all of this increase can be attributed to second-generation antipsychotics (SGAs). Major international differences are evident in the literature. European studies describe lower overall frequencies of use than North American studies (most of which were conducted in the United States). SGAs in children and adolescents are used more often in boys than in girls, and are increasingly used for treatment of attention-deficit hyperactivity disorder (ADHD) and conduct disorder (CD). Conclusions:Determining the most appropriate frequency of SGA use in children and adolescents will ultimately depend on decisive clarification of risks and benefits. The currently available literature highlights large international differences in the frequency of use. These differences may reflect fundamental dissimilarities in the therapeutic stance adopted toward ADHD and CD by physicians practicing in different countries. W W WObjectif : Au Canada, le traitement des enfants et des adolescents par antipsychotiques est presque toujours non indiqué sur l'étiquette. Un seul agent atypique, l'aripiprazole, a reçu récemment l'autorisation réglementaire d'utilisation auprès du groupe des 15 à 17 ans. Cette approbation réglementaire se limitait au traitement de la schizophrénie. L'objectif de cette revue était de résumer les études pharmaco-épidémiologiques qui examinent la fréquence d'utilisation de ces médicaments.Méthodes : Une recherche de la littérature a servi à identifier les études en anglais qui examinent la pharmaco-épidémiologie des antipsychotiques chez les enfants et les adolescents. Les résultats des études identifiées ont été résumés à l'aide de méthodes de revue narrative. Résultats :Dans les pays qui disposent de données longitudinales, une utilisation accrue des antipsychotiques a été observée régulièrement. Généralement, une grande partie ou la totalité de cet accroissement peut être attribuée aux antipsychotiques de deuxième génération (ADG). Des différences majeures entre les pays sont manifestes dans la littérature. Les études européennes décrivent des fréquences d'utilisation globalement plus faibles que les études nord-américaines (dont la plupart ont été menées aux États-Unis). Les ADG chez les enfants et les adolescents so...

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Prevalence, incidence and persistence of antipsychotic drug prescribing in the Italian general population: retrospective database analysis, 1999–2002

Cited by 32 publications

References 46 publications

Prescribing pattern of antipsychotic drugs in the Italian general population 2000–2005: a focus on elderly with dementia

Prescribing pattern of antipsychotic drugs in the Italian general population 2000–2005: a focus on elderly with dementia

Dispensing of psychotropic drugs to adults in community pharmacies in Latvia

A Review of Pharmacoepidemiologic Studies of Antipsychotic Use in Children and Adolescents

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