Prevalence, incidence, and risk factors for hepatitis C virus infection in hemodialysis patients

Jadoul, Michel; Bieber, Brian; Martin, Paul; Akiba, Takashi; Nwankwo, Chizoba; Arduino, Jean Marie; Goodkin, David A.; Pisoni, Ronald L.

doi:10.1016/j.kint.2018.11.038

Cited by 108 publications

(137 citation statements)

References 36 publications

Supporting

Mentioning

123

Contrasting

Unclassified

Order By: Relevance

“…This prevalence is within the previously reported range in our country for patients undergoing dialysis and it is significantly higher than that described in the general population [13,14,21,22]. This situation is repeated all over the world, with people who attend HD centres being a high-risk group for HCV infection [2,6]. In addition, prevalence was associated with time on dialysis.…”

Section: Discussionsupporting

confidence: 79%

“…In this context, Besonne et al, reported an outbreak of HBV and HCV in HD patients in the city of Rosario, Argentina [33,34]. However, several studies worldwide have indicated that the prevalence of HBV, HCV and HIV tends to be higher in patients in dialyzing settings than in the general population [2,6]. This finding suggests a close association between undergoing dialysis and being infected.…”

Section: Discussionmentioning

confidence: 99%

“…This issue is a major healthcare concern, since these viruses are a significant cause of increased morbidity and mortality [3]. The prevalence rate varies among countries and even among health centres within the same area [2,[4][5][6]. Coinfection is a common finding among HD patients and it may be associated with the worst clinical outcomes [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Seroprevalence of hepatitis B, hepatitis C and HIV infection among patients undergoing haemodialysis in Buenos Aires, Argentina

Pereson

Martínez

Isaac

et al. 2021

Journal of Medical Microbiology

View full text Add to dashboard Cite

Introduction. Blood-borne infections are a major cause of harm in individuals on haemodialysis (HD). In particular, knowledge about hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) status in HD patients is a major concern, since these infections may cause comorbidities in this setting. There is a paucity of data regarding this issue in Argentina. Hypothesis/Gap Statement. The epidemiological surveillance of HBV, HCV, and HIV is a fundamental tool for planning and implementing health strategies in order to prevent and control viral transmission of these viral agents. Aim. To determine the seroprevalence of HBV, HCV and HIV infections in HD patients in Buenos Aires, Argentina. Methodology. Seven hundred and forty-eight HD patients were included in a retrospective cross-sectional study. Serological assays were performed to determine HBV, HCV and HIV status. HBV HBsAg and anti-HBc IgG were analysed using AxSYM (samples before 2010) or the Architect Abbott system (samples since 2010), anti-HCV IgG testing was performed using the anti-HCV enzyme immunoassay AxSYM HCV V3.0 and ARCHITECT anti-HCV, while HIV was tested for using AxSYM HIV 1/2 gO and ARCHITECT HIV Ag/Ab Combination. HCV genotyping was carried out by phylogenetic analysis of the NS5B partial gene. Results. Infection with one of the viruses was detected in 31.1 % of patients [HBV in 82 (11.0 %), HCV in 179 (23.9 %) and HIV in 6 (0.8 %)]. Thirty-two (4.3 %) patients had 2 virus markers [27 (3.6 %) with HCV/HBV, 4 (0.5 %) with HCV/HIV and 1 (0.13 %) with HBV/HIV]. Finally, a single patient (0.13 %) presented all three markers. Time on dialysis was correlated with HCV but not with HBV infection. The HCV subtype distribution in HD patients was inverted with respect to that observed in the general population (HCV-1a 73.2 % and HCV-1b 26.8 % in HD vs HCV-1a 26.5 % and HCV-1b 73.5 % in the general population, P <0.001). Conclusion. Despite the implementation of universal precautionary biosafety standards for dialysis, infection with HBV and HCV continues to occur at very high rates in HD patients. The results emphasize the need to carry out proactive tasks for early diagnosis and treatment of infected individuals and to vaccinate those with non-protective antiHBs antibodies in order to reduce morbidity and mortality in HD patients.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Seroprevalence of hepatitis B, hepatitis C and HIV infection among patients undergoing haemodialysis in Buenos Aires, Argentina

Pereson

Martínez

Isaac

et al. 2021

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…DOPPS data indicate a 9.9% worldwide prevalence of hepatitis C in HD patients with rates ranging from 4% ‐ 20% in individual countries. Three or more cases of seroconversion within HD units over a median of 1.1 years were seen in 10% of units, most believed to be nosocomial …”

mentioning

confidence: 98%

Briefly Noted

Sherman¹

2019

Seminars in Dialysis

View full text Add to dashboard Cite

According to a Cox analysis of data from 13,249 HD patients over 65 years old, high intensity IV iron administration strategies (i.e., giving iron with high iron indices) are associated with higher mortality and infection risk than low intensity strategies.1The metabolism of oxycodone and its active metabolite oxymorphone were assessed in 9 HD patients; single 5 mg doses were given before HD and on a day between HD treatments. Data indicated the oxycodone can be used in the usual doses in dialysis patients though a small increase in clearance is seen with HD (half-life 3.9 hrs during a 4 hr HD and 5.7 hrs in the interdialytic interval). 2The reported increased mortality risk of patients returning to dialysis after graft failure was not confirmed in a study of 318 such patients. The difference in findings compared to earlier studies was attributed to better multivariate adjustments for the many differences between transplanted and transplant naïve patients. 3 An observational study of 6797 HD patients found that the mean post-weekend phosphate level was higher than the midweek value (5.5 v 5.2 mg/dL); the length of the interdialytic interval did not affect serum calcium or PTH levels. The serum phosphate range

show abstract

“…

Hepatitis C virus (HCV) infection remains commoner in patientswith chronic kidney disease (CKD) than the population at large. 1 In the haemodialysis (HD) population, HCV infection in part reflects acquisition of infection within dialysis units where its transmission can be effectively prevented by meticulous attention to body fluid precautions. 2 A series of studies have confirmed that HCV transmission on HD reflects lack of adherence to these precautions.

…”

mentioning

confidence: 99%