Prevalence of active infection withChlamydia pneumoniae and human cytomegalovirus in patients with type II diabetes mellitus

Roubalová, K; Brož, Jan; Hrubá, D; Hýblová, M; Kraml, Pavel

doi:10.1007/bf02931311

Cited by 5 publications

(10 citation statements)

References 12 publications

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“…Thus far, no relationships between glucose regulation and CMV seropositivity had been confirmed at the population level [27-30]. Three earlier studies investigated notably younger participants with comorbidities in relatively small cohorts [27-29].…”

Section: Discussionmentioning

confidence: 99%

“…Three earlier studies investigated notably younger participants with comorbidities in relatively small cohorts [27-29]. Age, ethnicity, income and education (socioeconomic factors) have not always been considered important confounders for CMV and diseases, although this is very likely to be the case especially for the latter [33,34].…”

Section: Discussionmentioning

confidence: 99%

“…However, recently it was shown that human pancreatic β-cells are susceptible to CMV infection [26]. At the population level, a clear positive association between CMV infection and type 2 diabetes has not yet been reported [27-30]. …”

Section: Introductionmentioning

confidence: 99%

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Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

et al. 2012

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BackgroundCytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old.ResultsCMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05).ConclusionsIn the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

et al. 2012

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“…An association between T1DM and C. pneumoniae infection has long been cited (Müller et al, 2003;Toplak et al, 1996) and several studies have shown an increased risk of C. pneumoniae infection in individuals with type 1 and type 2 diabetes (Roubalová et al, 2007;Lutsey et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…C. pneumoniae establishes a latent infection in some cell types, with life-long persistence of the bacteria in the infected body, participating in the formation of atherosclerotic plaques and potentiating the inflammatory reaction at the site of infection (Roubalová et al, 2007). It can establish persistent infection in macrophages, associated with an alteration of their function, and can modulate the host immune response (Roubalová et al, 2007;Bulut et al, 2002); these immune cell populations are probably the deterrent to some autoimmune diseases such as T1DM (insulin-dependent) (Sechi et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Chlamydia pneumoniae infection in adolescents with type 1 diabetes mellitus

Rizzo

Paolillo

Iafusco³

et al. 2012

Journal of Medical Microbiology

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Chlamydia pneumoniae, an intracellular bacterium, is associated with respiratory diseases, reinfectivity and chronic diseases such as cardiovascular disease, hypertension and stroke. The risk of infection is higher and infections are a serious clinical problem in patients with type 1 (insulin-dependent) diabetes mellitus (T1DM). Although diabetes mellitus and hyperglycaemia are considered possible risk factors for various types of aetiological agents, the epidemiological evidence concerning C. pneumoniae infection is scanty. The aim of the present study was to evaluate the impact of glycosylated haemoglobin (HbA1c) levels, an indicator of a hyperglycaemic state, on C. pneumoniae infection and disease chronicity; in addition we compared the duration of diabetes with the occurrence of C. pneumoniae infection. C. pneumoniae blood real time PCR and serology (IgG, IgA and IgM) assays by an ELISA method were performed. C. pneumoniae DNA was detected in 46.5 % [95 % confidence interval (CI)535.1-57.9 %] of the patients with T1DM; this prevalence is higher (P,0.05) than in non-diabetic paediatric controls, 10.5 % (95 % CI53.6-17.4 %). IgG/IgA C. pneumoniae antibody positivity was significantly (P¡0.05) more common in patients in poor metabolic control (HbA1c .9 %) versus patients in good metabolic control (HbA1c ,7 %), suggesting that the metabolic control of the disease is compromised in the patients with T1DM. In conclusion, adolescents with T1DM were more likely to show signs of infection with C. pneumoniae compared with healthy adolescents and the results suggest an increased risk of progressing from an acute C. pneumoniae infection to a chronic form.

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Non-autoimmune diabetes mellitus and the risk of virus infections: a systematic review and meta-analysis of case-control and cohort studies

Lontchi-Yimagou

Feutseu

Kenmoe

et al. 2021

Sci Rep

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A significant number of studies invoked diabetes as a risk factor for virus infections, but the issue remains controversial. We aimed to examine whether non-autoimmune diabetes mellitus enhances the risk of virus infections compared with the risk in healthy individuals without non-autoimmune diabetes mellitus. In this systematic review and meta-analysis, we assessed case-control and cohort studies on the association between non-autoimmune diabetes and viruses. We searched PubMed, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and Web of Science with no language restriction, to identify articles published until February 15, 2021. The main outcome assessment was the risk of virus infection in individuals with non-autoimmune diabetes. We used a random-effects model to pool individual studies and assessed heterogeneity (I2) using the χ2 test on Cochrane’s Q statistic. This study is registered with PROSPERO, number CRD42019134142. Out of 3136 articles identified, we included 68 articles (90 studies, as the number of virus and or diabetes phenotype varied between included articles). The summary OR between non-autoimmune diabetes and virus infections risk were, 10.8(95% CI: 10.3–11.4; 1-study) for SARS-CoV-2; 3.6(95%CI: 2.7–4.9, I2 = 91.7%; 43-studies) for HCV; 2.7(95% CI: 1.3–5.4, I2 = 89.9%, 8-studies;) for HHV8; 2.1(95% CI: 1.7–2.5; 1-study) for H1N1 virus; 1.6(95% CI: 1.2–2.13, I2 = 98.3%, 27-studies) for HBV; 1.5(95% CI: 1.1–2.0; 1-study) for HSV1; 3.5(95% CI: 0.6–18.3 , I2 = 83.9%, 5-studies) for CMV; 2.9(95% CI: 1–8.7, 1-study) for TTV; 2.6(95% CI: 0.7–9.1, 1-study) for Parvovirus B19; 0.7(95% CI: 0.3–1.5 , 1-study) for coxsackie B virus; and 0.2(95% CI: 0–6.2; 1-study) for HGV. Our findings suggest that, non-autoimmune diabetes is associated with increased susceptibility to viruses especially SARS-CoV-2, HCV, HHV8, H1N1 virus, HBV and HSV1. Thus, these viruses deserve more attention from diabetes health-care providers, researchers, policy makers, and stakeholders for improved detection, overall proper management, and efficient control of viruses in people with non-autoimmune diabetes.

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Prevalence of active infection withChlamydia pneumoniae and human cytomegalovirus in patients with type II diabetes mellitus

Cited by 5 publications

References 12 publications

Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

Chlamydia pneumoniae infection in adolescents with type 1 diabetes mellitus

Non-autoimmune diabetes mellitus and the risk of virus infections: a systematic review and meta-analysis of case-control and cohort studies

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