Prevalence of Acute and Chronic Forms of Leukemia in Various Regions of Khyber Pakhtunkhwa, Pakistan: Needs Much More to be done!

Ahmad, Shujaat; Kifayatullah,; Shah, Kiramat Ali; Hussain, Haya; Haq, Anwar Ul; Ullah, Abid; Khan, Asaf; Rahman, Najm Ur

doi:10.3329/bjms.v18i2.40689

Cited by 12 publications

(15 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A similar study reported leukemias among 24.76% of the studied bone marrow examined cases, with acute lymphoblastic leukemia as the commonest hematological malignancy 23 . In contrast, a more recent study from KPK reports a high prevalence of acute leukemia than chronic leukemia 24 . Most frequent among acute leukemias were acute lymphocytic leukemia (49.5%) followed by acute myelogenous leukemia (31.25%), while among chronic conditions, chronic myelogenous leukemia was observed in only 10% of the enrolled population, followed by chronic lymphocytic leukemia (9.25%).…”

Section: Discussionmentioning

confidence: 75%

Spectrum of hematological disorders in bone marrow aspirate and biopsy at tertiary care hospital, Karachi

Arshad

Sajjad

Mona

et al. 2021

Int. j. endorsing health sci. res.

View full text Add to dashboard Cite

Background: Bone marrow analysis is an invasive practice applicable to identifying, staging, and pursuing tumours. The present study aimed to determine the frequency of malignant hematological disorders using bone marrow aspirate and biopsy at Dr. Ishrat ul Ebad Khan Institute of Blood Diseases (DIEKIBD). Methodology: In this retrospective study, 756 patient records were examined for bone marrow analysis including both aspiration & biopsy, from January 2014 to December 2018. The posterior superior iliac crest was preferred for bone marrow sampling and aspiration was done with the help of a Salah bone marrow needle. Results: It was observed that about half of the bone marrow examinations, i.e. 362 (47%), were carried out for tumour staging. Of which 260 (71.8%) were not compromised by primary diseases, while 102 (28.17%) cases contained primary diseases. Among non-malignant hematological disorders, megaloblastic anemia and mixed deficiency anemia were the most frequent, i.e. 24 (3.1%) each. In comparison, chronic myeloid leukemia and chronic lymphocytic leukemia were the most prevalent malignant hematological disorders 42(5.5%) each. Conclusion: As per the study results, the pathological analysis of bone marrow via aspirate and trephine biopsy has comparatively more significant value in diagnosing and staging the malignant disorders than the non-malignant disorders.

show abstract

Section: Discussionmentioning

confidence: 75%

Spectrum of hematological disorders in bone marrow aspirate and biopsy at tertiary care hospital, Karachi

Arshad

Sajjad

Mona

et al. 2021

Int. j. endorsing health sci. res.

View full text Add to dashboard Cite

show abstract

“…Além disso destaca-se a importância de um estilo de vida saudável materno por meio de alimentação saudável, atividade física regular, sem No Brasil tanto as crianças como os adolescentes do sexo masculino foram mais afetados pela leucemia que o sexo feminino (Figura 3). Em uma província do Paquistão, a leucemia linfoide aguda foi mais prevalente em crianças e adolescentes do sexo masculino (AHMAD et al, 2019). Mas na Suécia, estudo evidenciou que a leucemia é similar entre os sexos sendo 13,2 por 100.000 casos em homens e 13,9 por 100.000 casos em mulheres (JULIUSSON et al, 2016).…”

Section: Resultsunclassified

Números De Casos E Mortalidade Por Leucemia Infantojuvenil No Brasil

Santos

Cardoso

2022

REMS

View full text Add to dashboard Cite

Objetivo: O objetivo desse estudo foi analisar os dados sobre números de casos e mortalidade por leucemia infantojuvenil no Brasil por meio das bases de dados secundárias entre os anos de 2007 e 2017. Métodos: trata-se de um estudo observacional do tipo transversal retrospectivo em bancos de dados secundários de acesso público. Os dados foram coletados dos bancos de dados Globocan (IARC – International Agency for Research on Cancer) e da BasePop (INCA - Instituto Nacional de Câncer José Alencar Gomes da Silva), no período de novembro de 2019 a fevereiro de 2020, considerando os critérios de inclusão: crianças e adolescentes (zero a 19 anos de idade), todas as etnias e ambos os sexos; leucemias linfoides e mieloides, sendo elas agudas e crônicas; dados de casos (números absolutos) e mortalidade em todo o Brasil (incluindo estados, capitais e municípios). Por outro lado, excluiu-se adultos, idosos, gestantes e outros tipos de câncer infantojuvenil. Resultados: o número de casos de leucemia infantojuvenil no Brasil foi maior na faixa etária de 15 a 19 anos, no sexo masculino e etnia como “outros”. Já a mortalidade por leucemia infantojuvenil foi mais expressiva na faixa etária de 15 a 19 anos, no sexo masculino e nas regiões nordeste e sudeste. Conclusão: após análise de oito gráficos, foi observada a necessidade de mais estudos abordando esse tipo de análise, bem como a atualização melhor das bases de dados brasileiras para um melhor estudo e posicionamento.

show abstract

“…This was in concurrent findings reported in Bangladesh in which HM was dominant in male patients with a male to female ratio of 2.2:1, and leukemia was more prevalent in male patients and male to female ratio was 1.8:1, in India male preponderance with a male to female ratio of 2.3:1, in Pakistan HM is more common in male with the ratio of 2.5:1. 9,30,40,43 The possible justification might be that male individuals are comparatively more exposed to the occupational and environmental carcinogenic agents which are at higher risk to the incidence of all kinds of leukemia. 44 In the current study, the myeloid type of HM was dominant and accounted for 53.8% of cases and CML accounted for 30.8% of the cases whereas AML accounted for 23% out of the confirmed cases.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Bone Marrow Confirmed Malignant and Non-Malignant Hematological Disorders in Patients with Abnormal Hematological Parameters in Northeast Ethiopia

Ebrahim¹,

Fiseha²,

Debash³

et al. 2022

JBM

View full text Add to dashboard Cite

Background Hematological disorders are heterogeneous conditions ranging from malignant to non-malignant disorders. Hematological malignancies comprise a collection of heterogeneous conditions originating from cells of the bone marrow and the lymphatic system. Therefore, this study aimed to determine the pattern of bone marrow confirmed malignant and non-malignant hematological disorders in patients with abnormal hematological parameters. Methods Institutional-based cross-sectional study was conducted in Dessie town from April 2020 to June 2021. A total of 228 study participants who had abnormal hematological parameters and referred for bone marrow examination were included consecutively. About 1.5 mL of bone marrow sample and 3 mL of venous blood sample were collected for bone marrow examination, complete blood count analysis and peripheral blood morphology examination. Wright stain, Sudan black B, and Prussian blue stains were used for staining the bone marrow and peripheral blood smears. The result was expressed in mean and standard deviation and presented in texts and tables. Ratio, frequency, and percentage were used to express the magnitude of malignant and non-malignant hematological disorders. Results The overall prevalence of hematological malignancies among the study participants was 11.4% with 8.8% in male patients. The prevalence of hematological malignancies were 3.5% CML, 2.6% AML, 1.8% CLL and MM, 0.9% ALL and undifferentiated acute leukemia. On the other hand, 57.0% of the study participants had non-malignant hematological disorders. Regarding non-malignant hematological cases, 24.6% were erythroid hyperplasia, 10.5% aplastic anemia, 8.8% concomitant IDA and MBA, 7.0% MBA, 3.5% leukemoid reaction, 1.8% IDA, and 0.9% visceral leishmaniasis. In patients with HM, 66.7% of AML, 100% of CML and CLL, and 75% of MM patients had increased total WBC count, whereas 66.7% of AML, 62.5% of CML, 75% of CLL, and 50% of MM patients had decreased hemoglobin level. On the other hand, 66.7% of AML, and 50% of CML, ALL, and CLL patients had decreased platelet count. Conclusion In this study, 11.4% of the patients had hematological malignant cases, whereas 57% of the patients had non-malignant hematological cases. Therefore, in patients with hematological abnormalities and where conclusive diagnosis could not be made through clinical and other laboratory investigations, bone marrow examination should be done for definitive diagnosis, management and prognosis.

show abstract

Prevalence of Acute and Chronic Forms of Leukemia in Various Regions of Khyber Pakhtunkhwa, Pakistan: Needs Much More to be done!

Cited by 12 publications

References 8 publications

Spectrum of hematological disorders in bone marrow aspirate and biopsy at tertiary care hospital, Karachi

Spectrum of hematological disorders in bone marrow aspirate and biopsy at tertiary care hospital, Karachi

Números De Casos E Mortalidade Por Leucemia Infantojuvenil No Brasil

Patterns of Bone Marrow Confirmed Malignant and Non-Malignant Hematological Disorders in Patients with Abnormal Hematological Parameters in Northeast Ethiopia

Contact Info

Product

Resources

About