Prevalence of Adhesions and the Associated Costs in General Surgery

Lange, D; Jeekel, J.

doi:10.1007/978-1-4612-1194-5_27

Cited by 8 publications

(7 citation statements)

References 55 publications

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“…All efforts directed at the reduction of the surgical trauma using laparoscopic access, powder-free gloves, meticulous preparation, and hemostasis, however, could not solve this problem. With increasing longevity and growing numbers of surgical procedures, the clinical workload and the socio-economic costs of adhesion-related diseases are constantly rising [6,7,8,9,10,11,12].…”

Section: Histologymentioning

confidence: 99%

Influence of intraperitoneal phospholipid dosage on adhesion formation and wound healing at different intervals after surgery

Müller

Treutner

Tietze³

et al. 2001

Langenbeck’s Arch Surg

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Section: Histologymentioning

confidence: 99%

Influence of intraperitoneal phospholipid dosage on adhesion formation and wound healing at different intervals after surgery

Müller

Treutner

Tietze³

et al. 2001

Langenbeck’s Arch Surg

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“…Adhesions occur in >90% of patients after abdominal surgery [1] and these can result in complications, e.g. intestinal obstructions, infertility in women, and chronic lower abdominal pain [2]. Parker et al [3] reported in a cohort study that 32.6% of patients who had lower abdominal surgery required a mean of 2.2 re‐admissions due to potential adhesion‐related problems.…”

Section: Introductionmentioning

confidence: 99%

Novel and simple method for isolating autologous mesothelial cells from the tunica vaginalis

et al. 2005

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collected by enzymatic disaggregation. To investigate the efficacy of mesothelial cells in preventing adhesion, harvested cells were transplanted into a rat intestinal hernia adhesion model. RESULTSCells isolated from the tunica vaginalis were homogenous, polygonal when confluent, expressed cytokeratin and vimentin, and the cell surface was covered with microvilli, which is the characteristic appearance of endogenous mesothelial cells. The transplantation of autologous mesothelial cell sheets reduced peritoneal adhesion. CONCLUSIONWe developed a new method of obtaining autologous mesothelial cells from the tunica vaginalis. These cells may provide a valuable option for treating patients at risk of postoperative adhesions.

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“…All efforts directed at the reduction of the surgical trauma by using laparoscopic access, powder-free gloves, subtle preparation, and meticulous hemostasis, however, have been of limited success. With increasing longevity and growing numbers of surgical procedures, the clinical workload and the socioeconomic costs of adhesion-related diseases are constantly rising [5][6][7][8][9][10].…”

Section: Original Researchmentioning

confidence: 99%

Influence of Early Drainage of Intraperitoneal Phospholipids on Efficacy of Adhesion Prevention

Müller

Treutner

Tietze³

et al. 2002

Journal of Investigative Surgery

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Postoperative peritoneal adhesions impose a long-term risk of morbidity and mortality. Adjunctive means are needed to prevent these complications. In previous studies we could demonstrate the efficacy and safety of intraperitoneally applied phospholipids with regard to adhesion prevention and wound healing, respectively. The assumption is that phospholipids rapidly adhere to the peritoneal surface and to the mesothelial lesions. This study was designed to evaluate the influence of early drainage of the administered fluid volume on the control of adhesion formation. Forty chinchilla rabbits underwent median laparotomy and standardized abrasion of circumscript areas of the ventral abdominal wall, the cecum, and the ileum. The animals randomly received either 75 mg/kg body weight of phospholipids in a volume of 5.0 mL/kg body weight (n = 20) or the same volume of Ringer's lactate solution (n = 20) prior to closing the laparotomy wounds. In 50% of the rabbits with either medication, 80% of the volume was recovered after 30 min before final closure of the abdominal wall ("drainage"). In the remaining animals the intraabdominal fluid load was not evacuated ("no drainage"). At day 10 after surgery all rabbits were sacrificed for evaluation of adhesion areas by computer-aided planimetry and histopathologic examination. The mean areas of adhesion in both Ringer's lactate groups were significantly larger than in the comparable phospholipid groups (p < .05). In the Ringer's lactate groups, adhesions averaged 341.7 (318.6) mm2 without and 263.3 (275.5) mm2 with drainage. In the phospholipid groups the respective mean areas reached only 24.6 (36.7) mm2 without drainage and 27.0 (49.7) mm2 following evacuation of the fluid 30 min after administration (median, mean in parentheses). These results prove the efficacy of phospholipids after a limited contact period of 30 min. The frequent use of drains in abdominal surgery will not impair the beneficial effect of phospholipids on prevention of adhesions.

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Prevalence of Adhesions and the Associated Costs in General Surgery

Cited by 8 publications

References 55 publications

Influence of intraperitoneal phospholipid dosage on adhesion formation and wound healing at different intervals after surgery

Influence of intraperitoneal phospholipid dosage on adhesion formation and wound healing at different intervals after surgery

Novel and simple method for isolating autologous mesothelial cells from the tunica vaginalis

Influence of Early Drainage of Intraperitoneal Phospholipids on Efficacy of Adhesion Prevention

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