Prevalence of allergic diseases in schoolchildren in relation to family history upper respiratory infections, and residential characteristics

Åberg, Nils; Sundell, Jan; Eriksson, Bo; Hesselmar, Bill; Aberg, B

doi:10.1111/j.1398-9995.1996.tb00073.x

Cited by 45 publications

(66 citation statements)

References 27 publications

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“…33 However, in the evaluation of incident disease, pets at home became a significant positive risk factor for wheezing, a symptom that is common before the diagnosis of asthma. Environmental tobacco smoke 10 -14,18,30 and dampness 5,10,11,30 have been reported to be risk factors for asthma, and were significant in relation to prevalent asthma in our cohort. These environmental risk factors did not appear as significant risk factors for development of asthma after ages 7 or 8 years.…”

Section: Discussionmentioning

confidence: 65%

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Incidence and Remission of Asthma in Schoolchildren: Report From the Obstructive Lung Disease in Northern Sweden Studies

et al. 2001

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ABSTRACT.Objective. An increasing prevalence of asthma has been reported worldwide as well as in Sweden. In 1996, the prevalence of asthma and type 1 allergy was investigated in a cohort of 3525 children 7 and 8 years old in 3 areas of northern Sweden. The aim of the present study was to estimate the incidence of asthma and to identify risk factors for incident cases over 1 year.Methods. The study started with a parental questionnaire, the International Study of Asthma and Allergies in Childhood questionnaire with additional questions, a skin prick test, and a validation study. The cohort was followed up after 1 year with the same questions. The response rate to the questionnaire was 97% in 1996, and 3339 children (97%) participated both in 1996 and 1997.Results. The incidence of physician-diagnosed asthma was 0.9/100/year; of wheezing, 3.8/100/year; and of new frequent or daily users of asthma medicines, 1.1/100/year. There was no difference by sex. The risk factor pattern based on incident cases of asthma was different from that based on prevalent cases. Significant risk factors for incident asthma were a positive skin test (odds ratio [OR]: 9.3; 95% confidence interval [CI]: 3.8 -22.7); low birth weight (OR: 7.4; 95% CI: 2.2-24.5); and family history of asthma (OR: 2.6; 95% CI: 1.1-6.3). Having or having had pets at home was associated with a decreased risk for asthma and wheezing based on prevalent cases, although it was associated with an increased risk for incidence of wheezing (OR: 2.9; 95% CI: 1.3-6.2). Remission of asthma, which was reported by 10% of the children with current asthma during 1 year, was associated with a negative skin test.Conclusion. The incidence of asthma at the age of 8 years was high, but remission was also common. Important risk factors for the development of asthma at this age were type 1 allergy, low birth weight, and family history of asthma. Furthermore, the results suggest that in a region where sensitivity to domestic animals is a strong risk factor for asthma, the presence of pets in the home may have different effects in early childhood compared with later in childhood. Pediatrics 2001;107(3). URL: http://www.pediatrics.org/cgi/content/full/107/3/e37; asthma, incidence, remission, risk factors, children.

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Section: Discussionmentioning

confidence: 65%

“…5,14,16,35 In our study, short duration of breastfeeding was a significant risk factor in 1996, 13 but not in 1997, and short breastfeeding was not significantly associated with incident asthma. Similarly, a history of respiratory infections was not related to incident asthma.…”

Section: Discussionmentioning

confidence: 70%

Incidence and Remission of Asthma in Schoolchildren: Report From the Obstructive Lung Disease in Northern Sweden Studies

et al. 2001

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“…The interrelationship between food allergy and asthma and eczema is known as the atopic march (Schroeder et al, 2009). The onset of infections, especially those with respiratory symptoms, may be a risk factor for developing allergies (Aberg et al, 1996). Moreover, a marginally positive significant trend was observed for PCDFs in the risk of asthma.…”

Section: Discussionmentioning

confidence: 81%

Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy

Miyashita

Sasaki

Saijo

et al. 2011

Environmental Research

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Dioxin-like compounds are endocrine disruptors. The effects of prenatal exposure to environmental levels of dioxins on immune function during infancy have not been clarified, although dioxins induce immunosuppression in offspring of animals. Moreover, human studies have not assessed the effects of gender-or congener-specific differences. The purpose of this study was to investigate the association between dioxin levels in maternal blood and the risk of infection and allergies in infancy. We examined 364 mothers and their infants enrolled in a Hokkaido Study on Environment and Children's Health between 2002 and 2005 in Sapporo, Japan. Relevant information was collected from a baseline questionnaire during pregnancy, medical records at delivery, and a follow-up questionnaire when the child was 18 months of age that assessed development of allergies and infections in infancy. Dioxin-like compound levels in maternal blood were measured with high-resolution gas chromatography/high-resolution mass spectrometry. Relatively higher levels of polychlorinated dibenzofuran were associated with a significantly increased risk of otitis media, especially among male infants (odds ratio = 2.5, 95% confidence interval = 1.1-5.9). Relatively higher levels of 2,3,4,7,8-pentachlorodibenzofuran were also associated with a significantly increased risk of otitis media (odds ratio = 5.3, 95% confidence interval = 1.5-19). However, we observed a weak association between dioxin-like compound levels and allergic symptoms in infancy. At environmental levels, prenatal exposure to dioxin-like compounds may alter immune function and increase the risk of infections in infancy, especially among males. The compound 2,3,4,7,8-pentachlorodibenzofuran may be responsible for this.

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“…In a crosssectional study in Taiwan, China, a significantly increased risk of rhinitis was found to be related to parental atopy [8]. The study by Åberg et al [25] also showed that the family history of the diseases was the strongest background factor for the development of children's asthma and allergic diseases. In addition, the study by Hwang et al [8] showed a significant effect of home dampness (or more specifically, water damage, and mold or mildew-derived allergens) on children's diagnosed rhinitis.…”

Section: Effects Of Household and Personal Characteristicsmentioning

confidence: 92%

Effects of ambient air pollution on allergic rhinitis among preschool children in Changsha, China

Deng

et al. 2013

Chin. Sci. Bull.

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Prevalence of allergic diseases in schoolchildren in relation to family history upper respiratory infections, and residential characteristics

Cited by 45 publications

References 27 publications

Incidence and Remission of Asthma in Schoolchildren: Report From the Obstructive Lung Disease in Northern Sweden Studies

Incidence and Remission of Asthma in Schoolchildren: Report From the Obstructive Lung Disease in Northern Sweden Studies

Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy

Effects of ambient air pollution on allergic rhinitis among preschool children in Changsha, China

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