Prevalence of anal, oral, penile and urethral Human Papillomavirus in HIV infected and HIV uninfected men who have sex with men

Ucciferri, Claudio; Tamburro, Manuela; Falasca, Katia; Sammarco, Michela Lucia; Ripabelli, Giancarlo; Vecchiet, Jacopo

doi:10.1002/jmv.24943

Cited by 38 publications

(33 citation statements)

References 41 publications

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“…The results showed that 59% of the subjects had infection at multiple sites, 34% at two sites and 22% at three sites. It is important to note that in oral mucosa HPV positive patients did not exhibit different values between HIV positive and negative subjects (10). In a similar study (20) where studied HPV at oral, genital and anal mucosa in HIV positive and negative males, observed that the virus was detected in the three samples simultaneously in 14% and 10% respectively.…”

Section: Discussionmentioning

confidence: 86%

“…Nevertheless, some authors reported the presence of HPV in different sites of the anogenital tract without clinical symptoms of infection. These studies report cases of simultaneous infection of the oral and genital mucosa (9)(10)(11). Studies on the prevalence of oral HPV infection in healthy individuals have revealed a high variability in different populations, with values ranging between 0.2% and 20.7% (12).…”

Section: Introductionmentioning

confidence: 99%

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Oral Human Papillomavirus: a multisite infection

Criscuolo¹,

Morelatto²,

Belardinelli³

et al. 2020

Med Oral

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Background: The Human Papillomavirus (HPV) has different strategies for persist in the cells. This characteristic has led us to consider the presence of the virus in tissues of the oral cavity that had no clinical signs of infection. The aim of this study was to detect the presence of DNA-HPV at multiple sites of the oral cavity. Material and Methods: A case-control study was designed: Oral Squamous Carcinoma Group (OSCG), healthy n=72 and Control Group (CG), n=72, healthy volunteers paired by sex and age with OSCG. Four samples were taken from OSCG: saliva, biopsy, brush scraping of lesion and contralateral healthy side. In CG a saliva sample and a scratch of the posterior border of tongue were collected. HPV was detected by PCR using Bioneer Accuprep genomic DNA Extraction kit, and consensus primers MY09 and MY11. Chi square test was applied. Results: 432 samples were obtained from 144 individuals. DNA-HPV was detected in 30 (42%) of OSCG subjects and 3 (4%) of CG. Two or more positive samples were obtained in 67% of the OSCG, 67% in saliva and 60% in biopsy; in CG 100% of the individuals were positive in the two samples. Conclusions: HPV is frequently present in oral cavity as a multifocal infection, even without the presence of clinical lesions.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Oral Human Papillomavirus: a multisite infection

Criscuolo¹,

Morelatto²,

Belardinelli³

et al. 2020

Med Oral

View full text Add to dashboard Cite

show abstract

“…Among MSM seropositive for HIV, the prevalence of HPV infection was 82.7% in China, 85% in Thailand and 85.3% in Taiwan 17,22,23 . On the other hand, the prevalence was even higher in Western countries, showing 97% in the United States and 96.3% in Italy 24,25 . Compared to MSM that were seropositive for HIV, those who were HIV seronegative had consistently lower prevalence of anal HPV infection, which was reported to be 58.5-73.3% and 70% in Asian and Western countries, respectively 17,[22][23][24][25] .…”

Section: Discussionmentioning

confidence: 94%

“…On the other hand, the prevalence was even higher in Western countries, showing 97% in the United States and 96.3% in Italy 24,25 . Compared to MSM that were seropositive for HIV, those who were HIV seronegative had consistently lower prevalence of anal HPV infection, which was reported to be 58.5-73.3% and 70% in Asian and Western countries, respectively 17,[22][23][24][25] . Another recent study among MSM of various ethnicities suggested that the estimated global prevalence of anal HPV infection among HIV seropositives and seronegatives was 79% and 47%, respectively 26 .…”

Section: Discussionmentioning

confidence: 94%

Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men

Hang

Strong

et al. 2020

Sci Rep

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Human papillomavirus (HpV) infection contributes to most anal cancers and premalignant intraepithelial lesions. this study investigated anal HpV infections and cytological abnormalities among men who have sex with men (MSM). Sociodemographic characteristics and sexual behaviorswere collected by using a structured questionnaire. Anal cytological results were examined, and HPV genotyping was performed by the Linear Array HPV Genotyping test. Logistic regression was used to estimate risk factors and their associations with high-risk HpV infection and cytological abnormalities. Among 163 MSM, 101 were seropositive for human immunodeficiency virus (HIV) and 62 were seronegative for HIV. The overall prevalence of HPV was 66.2%. A total of 61.9% and 48.2% of participants had never acquired any of either the quadrivalent or nonavalent vaccine HPV types, respectively. Cytological findings showed 15.3% atypical squamous cells of undetermined significance, 16.6% low-grade squamous intraepithelial lesion, 4.9% atypical squamous cells that cannot exclude high-grade squamous intraepithelial lesion and 17% high-grade squamous intraepithelial lesion. The number of high-risk HPV types was the predominant risk factor for abnormal anal cytology (OR 2.02, 95% CI 1.27-3.24). Infection with high-risk HPV was a significant predictor for cytological abnormality. MSM should be encouraged to obtain the HpV vaccine.Human papillomavirus (HPV) is an important cause of sexually transmitted diseases worldwide and is associated with malignant transformations in the squamous epithelium of the anus 1 . A rising trend in the incidence of anal cancer has been shown in recent years, increasing from 0.8 per 100,000 person-years in 1975 to 1.8 per 100,000 person-years in 2014 in the United States 2 . The development of anal cancer or pre-cancerous lesions is associated with one's lifetime number of sexual partners, human immunodeficiency virus (HIV) infection, receptive anal intercourse and anal HPV infection, particularly infection with HPV16 3-5 . Moreover, among individuals with anal cancer, nearly 90% of cases are attributable to HPV infection 6 . A recent meta-analysis also showed that the increased prevalence of HPV is associated with the severity of abnormal anal cytology 7 .The incidence of anal cancer among patients with HIV infection is much higher than among the general population (51.4 versus 1.2 per 100,000 person-years) 8 . HIV infection may attenuate the host's immune competence, which then worsens the control of anal HPV infections 9-11 . In addition, HIV seropositives have a decreased probability of clearing anal HPV infection and have prolonged anal HPV infections, compared to HIV seronegatives 11 . The persistent anal HPV infections have been particularly found in high-risk HPV types, which are the predominant risk factors for anal cancer 12,13 . Thus, HIV infection is considered one of the most important independent risk factors for high-risk anal HPV infection [14][15][16][17] .first amplified using polymerase chain reaction. Then...

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“…HPV's are recognized as one of the major causes of sexually transmitted infections related to cancer worldwide, and have been detected in cervical, anal and oral high-grade intraepithelial lesions [1][2][3]. Among them, HPV type 16 is the most common one, causing the majority of cervical and anogenital cancer as well as an important proportion of head and neck cancers [4][5][6][7][8][9][10]. Oral infection with HPV16, is associated with oropharyngeal cancer (OPC) and the oral sex play an important role in their acquisition [11,12].…”

Section: Introductionmentioning

confidence: 99%

High prevalent human papillomavirus infections of the oral cavity of asymptomatic HIV-positive men

et al. 2020

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Background: Incidence of anal and oral infections with Human Papillomavirus (HPV) is increasing, particularly among Human Immunodeficiency Virus-positive (HIV+) men. HPV type 16 has exhibited the highest incidence and only limited data is available on other prevalent types, variants of HPV16, as well as associated factors. We were interested in identifying prevalent HPV types, variants of type 16, as well as factors associated with HPV16 infections in the oral cavity of HIV+ men who have sex with men (MSM). Methods: A cross-sectional study of oral cavity samples from HIV+ MSM, that in a previous study were identified as positive for HPV16 in the anal canal. Cells from the oral cavity (102 samples, paired with 102 from the anal canal of same patient) were used to extract DNA and detect HPV infections using INNO-LiPA HPV Genotyping Extra II, and PCR. From these, 80 samples (paired, 40 anal and 40 oral) were used to identify variants of type 16 by sequencing. Statistical differences were estimated by the X 2 test, and p values equal to or less than 0.05 were considered significant. SPSS ver. Twenty-four statistical software (IBM Corp) was used. Results: We found a high prevalence of High-Risk HPV (HR-HPV) and Low-Risk HPV (LR-HPV). Patients were positive in the oral cavity for HR types; 16, 39 and 18 (80.4, 61.8 and 52.9% respectively) and LR types 11 and 6 (53.9 and 34.3% respectively). Surprisingly, only European variants of type 16 were found in the oral cavity, although American Asian (22.5%) and African (2.5%) variants were identified in the anal canal. The analysis showed that CD4 counts could be the most important risk factor associated with HR-HPV infections in the oral cavity, anal canal or both anatomical regions. The risk of infection of the oral cavity with type 18 increased in men diagnosed with HIV for more than 6 years. Conclusions: Prevalence of both HR and LR HPV's in the oral cavity of Mexican HIV+ MSM is very high. The fact that only European variants of HPV16 were found in the oral cavity suggest a possible tropism not previously described.

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Prevalence of anal, oral, penile and urethral Human Papillomavirus in HIV infected and HIV uninfected men who have sex with men

Cited by 38 publications

References 41 publications

Oral Human Papillomavirus: a multisite infection

Oral Human Papillomavirus: a multisite infection

Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men

High prevalent human papillomavirus infections of the oral cavity of asymptomatic HIV-positive men

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