Prevalence of anti-Toxoplasma IgG and IgM in hemodialysis patients comparing to healthy individuals in Sistan area, Iran

Dorri, Mohammad; Dabirzadeh, Mansour; Maroufi, Yahya; Afshari, Mahdi; Badri, Milad

doi:10.15171/npj.2017.13

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…Of the 1,659 identified articles, 10 were included, and the results from these studies were weighted ( Table 1 ) [ 40 - 49 ]. One study was removed due to over-matching [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran

Foroutan

Rostami²,

Majidiani

et al. 2018

Epidemiol Health

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OBJECTIVESToxoplasmosis is a parasitic disease that occurs worldwide, with a wide range of complications in immunocompromised patients. This systematic review and meta-analysis was performed to evaluate the seroprevalence of Toxoplasma gondii among patients undergoing hemodialysis in Iran.METHODSWe searched English and Persian databases for studies reporting T. gondii seroprevalence in Iranian hemodialysis patients through December 31, 2017. Inclusion and exclusion criteria were applied.RESULTSA total of 10 studies containing 1,865 participants (1,048 patients and 817 controls) met the eligibility criteria. Immunoglobulin G (IgG) antibodies against T. gondii were found in 58% (95% confidence interval [CI], 46 to 70) of hemodialysis patients and 40% (95% CI, 31 to 50) of healthy controls, while immunoglobulin M (IgM) antibodies were found in 2% (95% CI, 0 to 6) of hemodialysis patients and 0% (95% CI, 0 to 1) of healthy controls. The meta-analysis showed that hemodialysis patients were significantly more likely to be seropositive for IgG (odds ratio [OR], 2.04; 95% CI, 1.54 to 2.70; p<0.001) and IgM (OR, 2.53; 95% CI, 1.23 to 5.22; p<0.001) antibodies against T. gondii infection than healthy individuals.CONCLUSIONSThe current study revealed a high prevalence of T. gondii infection in hemodialysis patients. Since hemodialysis patients are immunocompromised and T. gondii can cause serious clinical complications, we recommend that periodic screenings for T. gondii infection should be incorporated into the routine clinical care of these patients.

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“…Of the 1,659 identified articles, 10 were included, and the results from these studies were weighted ( Table 1 ) [ 40 - 49 ]. One study was removed due to over-matching [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran

Foroutan

Rostami²,

Majidiani

et al. 2018

Epidemiol Health

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show abstract

“…This seroprevalence rate of latent infection is similar with Khalili et al study in Chaharmahal and Bakhtiari province (45.0%) [ 25 ]. In the majority of studies in different parts of Iran such as Tehran (60.0%) [ 26 ], Sistan and Baluchistan (73.7%) [ 27 ], East Azerbaijan (70.2%) [ 24 ], Guilan (72.0%) [ 22 ], Mazandaran (80.0%) [ 21 ], Isfahan and Qom provinces (63.0%) [ 28 ], the seropositivity in patients undergoing hemodialysis were reported over 60%, while the lower seroprevalence rate of T. gondii infection was reported by Saki et al from Khuzestan province (29.3%) [ 23 ] and Arefkhah et al from Kohgiluyeh and Boyer-Ahmad province (27.7%) [ 16 ]. The disagreement between studies is may be due to several reasons, including, study area, the number of participants, type of sampling, methodology, cultural habits of the subjects, different cutoff values or antibody titers and so on.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence and associated risk factors of Toxoplasma gondii infection in patients undergoing hemodialysis and healthy group

et al. 2020

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Objectives In this study, the seroprevalence of anti-Toxoplasma gondii (T. gondii) specific antibodies in patients undergoing hemodialysis compared to the control group were evaluated. In this case–control study, 200 hemodialysis patients (HDP) and 100 healthy controls were participated. The specific antibodies (IgG/IgM) in both groups were tested using enzyme-linked immunosorbent assay (ELISA) method. A structured questionnaire containing some demographic information was completed for each person in case and control groups. Results The overall seroprevalence of T. gondii infection was 49.5% (99/200) and 23.0% (23/100) in the case and control groups, respectively. There was a significant association between seroprevalence of T. gondii infection and contact with cats (P < 0.001), consumption of raw/undercooked meat (P = 0.01), and source of drinking water (P = 0.001) in the hemodialysis patients. Also, in the control subjects, there were a significant association between consumption of raw/undercooked meat (P = 0.04) and source of drinking water (P = 0.001) with T. gondii infection. The findings showed a high seroprevalence of T. gondii infection in HDP compared with healthy controls; thus, we recommend the regular screening programs for T. gondii infection in this susceptible group.

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“…Patients suffering from cancer, patients with organ transplant, on-dialysis patients, and patients who take immunosuppressants are at risk of toxoplasmosis. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiology of Toxoplasma gondii in diabetic patients type 2 by enzyme-linked immunosorbent assay method in Zabol City, 2017–2018

Dabirzadeh,

Sargazi,

Bagheri

2024

Journal of Research in Medical Sciences

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Background: Type 2 diabetes mellitus (T2DM) is prone to opportunistic infections, including toxoplasmosis, due to an immunodeficiency system. This study aimed to evaluate the serum of people with T2DM to determine the titer of anti-toxoplasma antibodies in patients and compare it with the control group. Materials and Methods: 720 blood samples have been carried out between October and the end of January 2017 in Sistan, and Baluchestan provinces in southeastern Iran, of these, 360 samples were related to healthy individuals (control), and 360 samples were related to T2DM individuals. The immunoglobulin (Ig) M and IgG enzyme-linked immunosorbent assay methods have been used to detect toxoplasmosis. The data were analyzed using SPSS-19, Chi-square, and Fisher’s exact test to compare statistical parameters. Results: In this cross-sectional study, out of 360 samples of T2DM by ELISA method, 60% samples in diabetic patients and 48.1% in control group were IgG positive (P < 0.05). Nearly 2.5% samples in diabetic patients and 0.3% in control group were IgM positive (P < 0.05). Conclusion: Anti-toxoplasma antibodies including IgG and IgM were higher in diabetic patient in comparison to control group.

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Prevalence of anti-Toxoplasma IgG and IgM in hemodialysis patients comparing to healthy individuals in Sistan area, Iran

Cited by 7 publications

References 17 publications

A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran

A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran

Seroprevalence and associated risk factors of Toxoplasma gondii infection in patients undergoing hemodialysis and healthy group

Seroepidemiology of Toxoplasma gondii in diabetic patients type 2 by enzyme-linked immunosorbent assay method in Zabol City, 2017–2018

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