Prevalence of antibiotic resistance in the tropical rivers of Sri Lanka and India

Kumar, Manish; Sulfikar,; Chaminda, Tushara; Patel, Arbind Kumar; Sewwandi, Himaya; Mazumder, Payal; Joshi, Madhvi; Honda, Ryo

doi:10.1016/j.envres.2020.109765

Cited by 22 publications

(15 citation statements)

References 47 publications

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“…The high consumption of antimicrobials causes an increase in the prevalence of ADR in several environmental compartments including drinking, waste and groundwater, sludge, sediments and municipal solid waste leachate ( Al-Judaibi, 2014 , Ferreira da Silva et al, 2007 , Kumar et al, 2020d , Kumar et al, 2020e , Ram and Kumar, 2020 , Zhang et al, 2015 , Storteboom et al, 2010 , Threedeach et al, 2012 ). In case of for example E.coli isolates from the effluent of WWTPs have shown a higher prevalence of antidrug resistance as compared to the influent, which is probably due to poor treatment conditions, prolonged microbial activities, and chemical properties of the antimicrobial drugs ( Reinthaler et al, 2003 , Silva et al, 2006 , Miranda and Castillo, 1998 , Marcinek et al, 1998 ).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, WWTPs are considered hotspots for the spreading ADR due to high microbial density, horizontal gene transfer (HGT), nutritional richness and the availability of antimicrobial metabolites ( Zhang et al, 2015 , Threedeach et al, 2012 , Silva et al, 2006 ). Previous studies have reported a correlation between the prevalence of ADR and inefficiently treated wastewater discharge, having abundance of Escherichia coli (E. coli) , extravasating to river and lake waters ( Na et al, 2018 , Yang et al, 2017 , Honda et al, 2016 , Honda et al, 2018 , Biswas et al, 2015 , Akhter et al, 2014 , Ram and Kumar, 2020 , Kumar et al, 2020d , Kumar et al, 2020e ). Thus, a better understanding of the occurrence, distribution and frequency of antidrug resistance in the urban waters is needed to prevent or slower the rate of increase in ADR.…”

Section: Introductionmentioning

confidence: 99%

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Antidrug resistance in the Indian ambient waters of Ahmedabad during the COVID-19 pandemic

Kumar

Dhangar

Thakur

et al. 2021

Journal of Hazardous Materials

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The ongoing COVID-19 pandemic increases the consumption of antimicrobial substances (ABS) due to the unavailability of approved vaccine(s). To assess the effect of imprudent consumption of ABS during the COVID-19 pandemic, we compare the 2020 prevalence of antidrug resistance (ADR) of Escherichia coli ( E. coli ) with a similar survey carried out in 2018 in Ahmedabad, India using SARS-CoV-2 gene detection as a marker of ABS usage. We found a significant ADR increase for in 2020 compared to 2018 in ambient water bodies, harbouring a higher incidence of ADR E.Coli towards non-fluoroquinolone drugs. Effective SARS-CoV-2 genome copies were found to be associated with the ADR prevalence. The prevalence of ADR depends on the efficiency of WWTPs (Wastewater Treatment Plants) and the catchment area in its vicinity. In year 2018 study, prevalence of ADR was discretely distributed, and the maximum ADR prevalence recorded was ~60%; against the current homogenous ADR increase, and up to 85% of maximum ADR among the incubated E.coli isolated from the river (Sabarmati) and lake (Chandola and Kankaria) samples. Furthermore, wastewater treatment plants showed less increase in comparison to the ambient waters, which eventually imply that although SARS-CoV-2 genes and faecal pollution may be diluted in the ambient waters, as indicated by low C t -value and E.coli count, the danger of related aftermath like ADR increase cannot be nullified. Also, Non-fluoroquinolone drugs exhibited overall more resistance than the quinolone drugs. Overall, this is probably the first ever study that traces the COVID-19 pandemic imprints on the prevalence of antidrug resistance (ADR) through wastewater surveillance and hints at monitoring escalation of other environmental health parameters. This study will make public and policyholders concerned about the optimum use of antibiotics during any kind of treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antidrug resistance in the Indian ambient waters of Ahmedabad during the COVID-19 pandemic

Kumar

Dhangar

Thakur

et al. 2021

Journal of Hazardous Materials

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“…Among the environmental pathways of AMR spread, wastewater has been regarded as the primary source of the emergence of AMR into water environment. Particularly, the discharge of untreated wastewater has been reported to result in signi cant increase in the prevalence of AMR in water environment in various countries [4][5][6][7][8][9] . Accordingly, wastewater treatment plants (WWTPs) have emerged as an important barrier to prevent the spread of AMR in wastewater into water environment.…”

Section: Introductionmentioning

confidence: 99%

Transition of antimicrobial resistome in wastewater treatment plants: impact of process configuration, geographical location and season

Honda

Matsuura

Hara-Yamamura

et al. 2022

Preprint

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Wastewater is the major source of the emergence of antimicrobial resistance (AMR) in water environment. Wastewater treatment plants (WWTPs) are the important barriers for preventing the spread of AMR in wastewater into water environment, as well as the reservoir of AMR, which can be potentially discharged into treatment effluent. In this study, the antimicrobial resistome in WWTP was investigated using systematic sampling and shotgun metagenomic analysis over a variety of geographical locations, seasons, and biological treatment configurations. The results revealed that the transition of antimicrobial resistome occurred at two locations during the course of wastewater treatment process to develop the distinctive antimicrobial resistome in influent wastewater, activated sludge, and treatment effluent regardless of the geographical locations of WWTPs. The antimicrobial resistome in influent wastewater was characterized by higher abundance of antibiotic resistance genes (ARGs) resistant to clinically important drug classes, whereas sludge retained a higher abundance of multidrug ARGs associated with efflux pump. Seasonality was the primary factor to characterize the antimicrobial resistome in influent wastewater, which was partially succeeded to the subsequent resistome of activated sludge and treatment effluent. Importantly, antimicrobial resistome in the treatment effluent was dependent on process configuration of sludge separation. With conventional final sedimentation, antimicrobial resistome in the treatment effluent was partially affected by the resistome in influent wastewater, suggesting some ARGs in influent wastewater bypassed biological treatment and final sedimentation to be retained in the treatment effluent. On the contrary, the resistome of MBR effluent was independent from wastewater resistome, suggesting good reduction of ARG to clinically important drugs originated from influent wastewater.

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“…Over the years, there have been updated reports of antibiotic resistance genes (ARGs), antibiotic resistant bacteria (ARB) and mobile genetic elements (MGEs) in wastewater release (effluents), water environments and wastewater treatment systems. Some of these studies revealed that ARGs in the water bodies are associated with the wide use of antibiotics for human/animal health and food preservative, which are released into the environment unchanged ( Kumar et al., 2020a , b ; Igere et al., 2020b ; Kemper, 2008 ; Rodriguez et al., 2006 ; Kim et al., 2005 ; Iversen et al., 2004 ). On the other hand, MGEs are myriad of mobile genetic materials that fuels adaptive/persistence of living organisms and are implicated in sharing/transfer of genetic elements (inter and intra).…”

Section: Introductionmentioning

confidence: 99%

“…Increase in industrialization, technological advancement, urban/population growth and development are the primary drivers of such sizeable transformations of water bodies which results descent of water quality and/or poor environmental wellness. Activities in advancing societies and built-environments {including the release of high composition of industrial chemicals (Nitrates, phosphates, chloride, ammonium, with other anions/cations and other transition elements)}, hospital waste release, domestic and household waste release as well as municipal release have also contributed to the poor state of water ( Kumar et al., 2020a , b ; Igere et al., 2020a ). The presences of these agents (ARGs/MGEs) in water bodies and its potential impact on the environment have aroused concern as its global impact continues to ascend geometrically.…”

Section: Introductionmentioning

confidence: 99%

Modern knowledge-scape possess petite influence on the factual persistence of resistance determinants (ARGs/MGEs): A map and assessment of discharged wastewater and water bodies

Igere¹,

Onohuean²,

Nwodo³

2022

Heliyon

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Prevalence of antibiotic resistance in the tropical rivers of Sri Lanka and India

Cited by 22 publications

References 47 publications

Antidrug resistance in the Indian ambient waters of Ahmedabad during the COVID-19 pandemic

Antidrug resistance in the Indian ambient waters of Ahmedabad during the COVID-19 pandemic

Transition of antimicrobial resistome in wastewater treatment plants: impact of process configuration, geographical location and season

Modern knowledge-scape possess petite influence on the factual persistence of resistance determinants (ARGs/MGEs): A map and assessment of discharged wastewater and water bodies

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