Prevalence of antiphospholipid antibodies among women experiencing unexplained infertility and recurrent implantation failure

Sauer, R; Roussev, Roumen G.; Jeyendran, Rajasingam S.; Coulam, Carolyn B.

doi:10.1016/j.fertnstert.2009.08.062

Cited by 55 publications

(37 citation statements)

References 14 publications

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“…Antiphospholipid antibodies have been described in patients with RIF. 11 We found persistently positive low-titer antiphospholipid antibodies in the presented case. Couples with RIF are not believed to share more HLA antigens with their spouses than expected by chance.…”

Section: Discussionsupporting

confidence: 51%

Coexistence of lymphocyte dysregulation, alloimmunity and autoimmunity in a patient with recurrent failed in vitro embryo transfer fertilization

Carbone

Gallego

Arraya

et al. 2014

Progresos de Obstetricia y Ginecología

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Objective: To describe a patient with primary infertility and recurrent implantation failure (RIF) and coexistence of peripheral blood immunophenotypic dysregulation of lymphocytes and alloimmune and autoimmune abnormalities. The hypothesis is that functionally distinct immunological abnormalities might better explain the immunological etiology of RIF than individual abnormalities in some patients. Subjects and methods:We present clinical and immunological data. Results: A patient with primary infertility and RIF had peripheral blood immunophenotypic abnormalities of T, B and NK-cells, unusually high shared HLA antigens with her partner, and antiphospholipid antibodies.Conclusion: Functionally distinct immunological abnormalities may coexist in some women with RIF after in vitro fertilization.Infertilidad; Fallo de implantación; Células NK; Activación linfocitaria; HLA Coexistencia de alteracion inmunofenotipica linfocitaria, aloinmunidad y autoinmunidad en una paciente con fallo de implantacion recurrente tras fecundacion in vitro Resumen Objetivo: Describir un caso de fallo recurrente tras fecundación in vitro en el que coexisten varias alteraciones inmunológicas potencialmente relacionadas con este problema. La hipótesis es que esta coexistencia de factores podría explicar mejor la etiología inmunológica que alteraciones individuales.Sujetos y métodos: Se presentan datos clínicos e inmunológicos.

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Section: Discussionsupporting

confidence: 51%

Coexistence of lymphocyte dysregulation, alloimmunity and autoimmunity in a patient with recurrent failed in vitro embryo transfer fertilization

Carbone

Gallego

Arraya

et al. 2014

Progresos de Obstetricia y Ginecología

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“…These antibodies are the most that AFS does not affect IVF success (49) . In this report, 16 review articles and 2053 cases have been investigated bot individually and globally and no statistically significant difference has been observed between AFS and IVF success (49) .…”

Section: H) Immunologic Factors and Thrombophiliasmentioning

confidence: 97%

Clinical and prognostic significance of genetic factors in recurrent in-vitro fertilization failures

Ocak¹,

Özlü²

2013

J Turk Soc Obstet Gynecol

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“…This thrombophilic condition is often associated with preterm delivery, vascular thrombosis, intrauterine growth retardation, intrauterine death, and abruptio placentae [11,12,13]. The prevalence of APAs among women with idiopathic infertility (8%) and among women experiencing recurrent implantation failure (9%) is significantly higher than that in fertile women (1.5%) [14]. Additionally, APA levels are elevated in patients with recurrent abortions.…”

Section: Antiphospholipid Syndromementioning

confidence: 99%

Roles of Antiphospholipid Antibodies, Antithyroid Antibodies and Antisperm Antibodies in Female Reproductive Health

et al. 2015

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Autoantibodies are implicated in various human diseases. In this review, the effects of three different types of autoantibodies (antiphospholipid antibody, antithyroid antibody, and antisperm antibody) on female reproductive health are critically examined. Antiphospholipid antibodies are being detected more frequently in women undergoing in vitro fertilization, but their presence does not appear to influence the outcome of pregnancy, miscarriage, or live birth rates. Available evidence makes it conclusive that antiphospholipid antibodies play negligible roles in recurrent miscarriage. Treatment with aspirin together with low-molecular-weight heparin appears to be effective for recurrent miscarriage. Although antithyroid antibodies are commonly found in women of reproductive age, implantation rates and miscarriage rates are unaffected when women have normal thyroid function. Women with thyroid dysfunction should be treated with L-thyroxine before conception or at early gestational stages to avoid pregnancy complications. Antisperm antibodies are uncommon but are most often associated with ovarian hypofunction. They are believed to cause fertilization failure when found at high titers in seminal plasma, or in the mucosal immune system of women. Intrauterine artificial insemination and in vitro fertilization/embryo transfer are effective treatment modalities for antisperm antibody-related infertility, although this remains a controversial topic in the field of female infertility.

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Prevalence of antiphospholipid antibodies among women experiencing unexplained infertility and recurrent implantation failure

Cited by 55 publications

References 14 publications

Coexistence of lymphocyte dysregulation, alloimmunity and autoimmunity in a patient with recurrent failed in vitro embryo transfer fertilization

Coexistence of lymphocyte dysregulation, alloimmunity and autoimmunity in a patient with recurrent failed in vitro embryo transfer fertilization

Clinical and prognostic significance of genetic factors in recurrent in-vitro fertilization failures

Roles of Antiphospholipid Antibodies, Antithyroid Antibodies and Antisperm Antibodies in Female Reproductive Health

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