2021
DOI: 10.1371/journal.pone.0252511
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Prevalence of asymptomatic or “silent” myocardial ischemia in diabetic patients: Protocol for a systematic review and meta-analysis

Abstract: Introduction Myocardial ischemia (MI) is a top ranked cause of death among diabetic patients, yet it is mostly asymptomatic or “silent”. There is a need for summary epidemiologic measures on this highly lethal and unnoticeable complication of diabetes. The proposed systematic review and meta-analysis aims to estimate of the global prevalence of silent MI among diabetic patients. Methods and analysis This protocol was prepared according to the preferred reporting items for systematic review and meta-analysis … Show more

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Cited by 13 publications
(11 citation statements)
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“…The study characteristics will be summarized and presented in tables. Heterogeneity among studies will be measured using the I 2 statistic to estimate the percentage of variation across studies, ranging from 0% to 100% [ 36 , 37 ], and its interpretation is as follows: a) I 2 = 0%–40%, low heterogeneity; b) I 2 = 30%–60%, moderate heterogeneity; c) I 2 = 50%–90%, substantial heterogeneity; and d) I 2 = 75%–100%, high heterogeneity [ 37 , 38 ]. Based on the I 2 statistic, we will determine whether a meta-analysis is feasible [ 28 , 29 , 39 ].…”
Section: Methodsmentioning
confidence: 99%
“…The study characteristics will be summarized and presented in tables. Heterogeneity among studies will be measured using the I 2 statistic to estimate the percentage of variation across studies, ranging from 0% to 100% [ 36 , 37 ], and its interpretation is as follows: a) I 2 = 0%–40%, low heterogeneity; b) I 2 = 30%–60%, moderate heterogeneity; c) I 2 = 50%–90%, substantial heterogeneity; and d) I 2 = 75%–100%, high heterogeneity [ 37 , 38 ]. Based on the I 2 statistic, we will determine whether a meta-analysis is feasible [ 28 , 29 , 39 ].…”
Section: Methodsmentioning
confidence: 99%
“…Heterogeneity among studies will be measured by the I 2 statistic to estimate the percentage of variation across studies, ranging from 0% to 100%, [37,38] and its interpretation is low heterogeneity when I 2 = 0%–40%; moderate heterogeneity when I 2 = 30%–60%; substantial heterogeneity when I 2 = 50%–90% represents a; and high heterogeneity when I 2 = 75%–100%. [28,39,40]…”
Section: Methodsmentioning
confidence: 99%
“…The tool comprises ten questions which assess internal validity (such as the suitability of case definition, reliability of study instrument, and the application of same measurement methods for all subjects) and external validity issues (such as the representativeness of the sample, participation rate, and the sampling technique). Out of a total of ten points, we will consider a study attaining a total score >8 as having a low risk of bias: score > 8, a score of 6–8 as moderate risk and a score of 0–5 as a high risk of bias: score 0–5 [ 12 , 32 ]. Inconsistencies in the judgment of reviewers will be mutually resolved by consensus.…”
Section: Methodsmentioning
confidence: 99%