Prevalence of Atopic Dermatitis in Chinese Children aged 1–7 ys

Guo, Yuxin; Li, Ping; Tang, Jianping; Han, Xiaoxu; Zou, Xiaoyan; Xu, Gang; Xu, Zigang; Wei, Fenglei; Liu, Qiang; Wang, Min; Xiao, Feng‐Li; Zong, Wenxia; Shen, Chunping; Li, Jianhong; Liu, Jianzhong; Luo, Yang; Chang, Jing; Sheng, Nan; Dong, Chun Bo; Zhang, Duo; Xing, Dan; Zhou, Junhu; Meng, Chi; Niu, Haobin; Shi, Xuemei; Zhang, Xinglian; Xiang, Jianbin; Hui, Xu; Ran, Qianting; Zhou, Yi; Li, Ming; Zhang, Hui; Cheng, Ruhong; Gao, Xing‐Hua; Wang, Hua; Gu, Heng; Ma, Lin; Yao, Zhirong

doi:10.1038/srep29751

Cited by 116 publications

(114 citation statements)

References 36 publications

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“…Atopic dermatitis prevalence is 30.48% in Chinese infants aged 1–12 months, which is much higher than that in the children aged 1–7 years (12.94%) . A higher prevalence of AD in infants is consistent with our previous findings that the disease prevalence decreases with age.…”

Section: Discussionsupporting

confidence: 90%

“…Two birth cohort studies in Germany have suggested that AD greatly improves or resolves until late childhood in up to 70% of cases, and that early and severe onset, family history of AD, and early allergen sensitizations are risk factors for a persistent course . Our previous study in children aged 1–7 years in China showed that the proportion of mild, moderate and severe AD was 74.60%, 23.96% and 1.44%, respectively. Thus, the combination of data from the infant group with those from the 1‐ to 7‐year‐old group in China indicates that not only severity but prevalence of AD often decreases with age.…”

Section: Discussionmentioning

confidence: 90%

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Phenotypic analysis of atopic dermatitis in children aged 1–12 months: elaboration of novel diagnostic criteria for infants in China and estimation of prevalence

Guo

Zhang

Liu

et al. 2019

Acad Dermatol Venereol

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Background Atopic dermatitis (AD) is the most common skin disorder in infancy. However, the diagnosis and definite significance of infantile AD remains a debated issue. Objective To analyse the phenotypes of AD in infancy, to establish diagnostic criteria and to estimate the prevalence of this condition in China. Methods This is a multicentric study, in which 12 locations were chosen from different metropolitan areas of China. Following careful and complete history‐taking and skin examination, the definite diagnosis of AD was made and the severity based on the SCORAD index was determined by local experienced dermatologists. Based on the detailed phenotyping, the major and representative clinical features of infantile AD were selected to establish the diagnostic criteria and evaluate their diagnostic efficacy. Results A total of 5967 infants were included in this study. The overall point prevalence of AD was 30.48%. The infantile AD developed as early as at the second month of life, and its incidence peaked in the third month of life at 40.81%. The proportion of mild, moderate and severe AD was 67.40%, 30.57% and 2.03%, respectively. The most commonly seen manifestations in the infantile AD were facial dermatitis (72.07%), xerosis (42.72%) and scalp dermatitis (27.93%). We established the novel diagnostic criteria of infants, which included: (i) onset after 2 weeks of birth; (ii) pruritus and/or irritability and sleeplessness comparable with lesions; and (iii) all two items above with one of the following items can reach a diagnosis of AD: (i) eczematous lesions distributed on cheeks and/or scalp and/or extensor limbs, and (ii) eczematous lesions on any other parts of body accompanied by xerosis. Conclusions In China, the prevalence of AD in infancy is 30.48% according to clinical diagnosis of dermatologists. The novel Chinese diagnostic criteria for AD in infants show a higher sensitivity and comparable specificity.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 90%

Phenotypic analysis of atopic dermatitis in children aged 1–12 months: elaboration of novel diagnostic criteria for infants in China and estimation of prevalence

Guo

Zhang

Liu

et al. 2019

Acad Dermatol Venereol

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“…[2] It used to be that AD was an infantile disease, but in this investigation, the proportion of adults in AD is greater than children. Both the overall incidence of AD and the proportion of adults in AD are clearly on the rise in China, which attested late-onset AD is a common phenomenon.…”

Section: Discussionmentioning

confidence: 99%

“…[1] In China, the overall prevalence of AD in 2016 is reported to be 12.94% by clinical diagnosis of dermatologists, while based on UK diagnostic criteria, it is 4.76% in children aged 1 to 7 years. [2] Very few studies have focused on adult AD, despite the fact that the occurrence of adult AD has obviously influenced socioeconomic conditions in both Asian and Western countries. [3,4] According to a study in Taiwan from August 2007 to May 2008, 90 adult patients with AD (8%) were identified by dermatologists’ diagnosis among nursing staff in a Taiwanese medical center.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and clinical features of adult atopic dermatitis in tertiary hospitals of China

Wang

Shi

et al. 2017

Medicine

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The prevalence of atopic dermatitis (AD) has increased substantially. Previous studies have focused mostly on pediatric patients, while epidemiological investigation on adult AD has been very limited.The aim of this study was to determine the prevalence and clinical features of adult AD in outpatients with dermatitis and eczema in China mainland.A multicenter cross-sectional study was conducted among outpatients with eczema or dermatitis from 39 tertiary hospitals of 15 provinces in China from July 1 to September 30, 2014.Of 8758 patients, 407 were adult AD. Compared with adults with other types of dermatitis, the mean age (41.8 ± 14.3 vs 42.04 ± 15.38 years, P < 0.05) and onset age (35.2 ± 11.2 vs 39.2 ± 14.0 years, P < 0.001) of adult AD were younger, and mean disease duration was longer (5.3 ± 7.1 vs 2.8 ± 4.9 years, P < 0.001). About 53.3% adult AD involved 3 or more body locations, higher than adults with other types of dermatitis (34.4%, P < 0.001), but lower than those with pediatric and adolescent AD (73.8%, P < 0.001). History of asthma (19.2% vs 6.9%, P < 0.001) or allergic conjunctivitis (21.9% vs 14.9%, P < 0.05) was more common in adult AD than pediatric/adolescent AD. Suspected bacterial infection was more frequently in adult AD than adults with other types of dermatitis (24.3% vs 14.6%, P < 0.001) and pediatric/adolescent AD (24.3% vs 14.9%, P < 0.001). More severe itching was observed in 31.4% of adult AD, higher than that of adults with other types of dermatitis (15.4%, P < 0.001), whereas similar to that of pediatric/adolescent AD (28.7%, P > 0.05). The highest (8.7%) and lowest prevalence (3.7%) of adult AD were in 25°N to 30°N and 35°N to 40°N latitude region.A substantial part of adult outpatients with eczema or dermatitis is adult AD. Middle age, more body location involvement, more suspected bacterial infection, and severe itching are the main clinical feathers of adult AD. Geographical environment and economic situation work in synergy to adult AD.

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“…A descriptive cross‐sectional study conducted in eight different districts in Shanghai in 2010 that included 10 436 children found a prevalence of AD of 8.3% . In addition, results of an epidemiological study conducted in 2013 and 2014 in 12 metropolises throughout China and including 13 998 children 1–7 years of age showed a prevalence of 12.94% (ranging 9.00–24.69% between metropolises) . Similar to other countries, there has been a trend of increasing prevalence of AD in China, with one study that compared ISAAC phase 1 data and ISAAC phase 3 data in children in Guangzhou City showing that the prevalence of AD in children aged 13–14 years increased from 1.7% in 1994–1995 to 3.0% in 2001 …”

Section: Ad Epidemiology In Asiamentioning

confidence: 96%

Burden of atopic dermatitis in Asia

Tsai

Rajagopalan

Chu

et al. 2019

The Journal of Dermatology

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Atopic dermatitis is a chronic, inflammatory skin disease characterized by intense pruritus and eczematous lesions. It is considered one of the most common chronic conditions, with an estimated global prevalence of nearly 230 million. As in the rest of the world, prevalence of atopic dermatitis has been increasing in Asian countries over the last few decades. This increased prevalence in Asian countries has been attributed to factors such as rapid urbanization, increasingly Westernized lifestyles, and improved standards of living and education. As a result, it is important to understand the increasing burden of disease in Asian countries and the differences between the countries in terms of epidemiology, diagnostic criteria, management, quality of life and economic burden.

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Prevalence of Atopic Dermatitis in Chinese Children aged 1–7 ys

Cited by 116 publications

References 36 publications

Phenotypic analysis of atopic dermatitis in children aged 1–12 months: elaboration of novel diagnostic criteria for infants in China and estimation of prevalence

Phenotypic analysis of atopic dermatitis in children aged 1–12 months: elaboration of novel diagnostic criteria for infants in China and estimation of prevalence

Prevalence and clinical features of adult atopic dermatitis in tertiary hospitals of China

Burden of atopic dermatitis in Asia

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