Prevalence of Attention-Deficit/Hyperactivity Disorder and Conduct Disorder Among Substance Abusers

Schubiner, Howard; Tzelepis, Angela; Milberger, Sharon; Lockhart, Nancy; Krüger, Michael; Kelley, Bobbe J.; Schoener, Eugene P.

doi:10.4088/jcp.v61n0402

Cited by 263 publications

(182 citation statements)

References 61 publications

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“…is highly prevalent (Drake & Wallach, 2000;Evans & Sullivan, 1995;Grant et al, 2004;Jacobsen, Southwick, & Kosten, 2001). Persons with co-occurring other mental disorders and SUD have a more persistent illness course and are more refractive to treatment than those without dual diagnoses (Brown, Recupero, & Stout, 1995;O'Brien et al, 2004;Schubiner et al, 2000;Swartz & Lurigio, 1999). Depression occurs in approximately 30% of chronic alcoholics (Regier et al, 1990).…”

Section: Clinical Considerations: Comorbidities Of Sud and Implicatiomentioning

confidence: 99%

EEG Biofeedback as a Treatment for Substance Use Disorders: Review, Rating of Efficacy and Recommendations for Further Research

Sokhadze¹,

Cannon²,

Trudeau³

2008

Journal of Neurotherapy

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Section: Clinical Considerations: Comorbidities Of Sud and Implicatiomentioning

confidence: 99%

EEG Biofeedback as a Treatment for Substance Use Disorders: Review, Rating of Efficacy and Recommendations for Further Research

Sokhadze¹,

Cannon²,

Trudeau³

2008

Journal of Neurotherapy

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“…The lifetime prevalence rates of major depression in the general population are notable, with rates ranging from 13-16% (Kessler et al 2003;Hasin et al 2005), while the rates of major depression in treatment-seeking cocaine abusers are higher, with rates ranging from 15-30% (Rounsaville and Carroll 1991;Kilbey, Breslau and Andreski 1992;Charney et al 2005;McLean et al 1999). Similarly, Kessler et al (2006) found that the rate of adult ADHD in the U.S. population is 4.4%, whereas recent prevalence studies in substance dependent samples seeking treatment have obtained rates ranging from 15-24% (Levin, Evans and Kleber 1998;King et al 1999;Schubiner et al 2000), suggesting that these disorders merit clinical attention in substance abuse treatment settings. Despite this, there remain only limited data characterizing the impact of these co-occurring psychiatric disorders on treatment outcome in cocaine dependent patients.…”

Section: Introductionmentioning

confidence: 98%

Effects of major depressive disorder and attention-deficit/hyperactivity disorder on the outcome of treatment for cocaine dependence

Levin¹,

Bisaga²,

Raby³

et al. 2008

Journal of Substance Abuse Treatment

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Co-occurring psychiatric disorders have been associated with poor prognosis among substance dependent patients, but few studies have examined this association among patients with cocaine dependence (CD). Baseline characteristics and treatment outcome were compared between cocainedependent patients with major depression (MDD) (N = 66), attention-deficit/hyperactivity disorder (ADHD) (N = 53), or cocaine dependence without comorbid disorders (CD alone) (N = 48), who had been randomized to the placebo arms of clinical trials of venlafaxine, methylphenidate, and gabapentin, respectively. The three groups differed significantly in racial makeup, with more Caucasians and Hispanics among patients with MDD or ADHD, and more African Americans among those with CD alone. The groups did not differ significantly in treatment retention, with retention rates ranging from 42-47%, or in the rates of achieving 2 consecutive weeks of urine-confirmed abstinence, with rates ranging from 40-50%. Using logistic regression for repeated measures with general estimating equations, modeling the likelihood of a cocaine positive week over time in treatment, diagnostic group was found to interact with the baseline level of cocaine use and time. Among cocaine dependent patients who achieved abstinence at baseline, the groups with MDD or ADHD had better outcome over time than those with CD alone. However, among patients with cocaine positive urines at baseline, MDD or ADHD were associated with poor outcome compared to patients with CD alone. The findings suggest that diagnosis and treatment of co-occurring disorders such as depression and ADHD may be an important component of treatment planning for cocaine dependence, and that baseline level of cocaine use should be included as a covariate in studies evaluating the impact of such treatment.

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“…Untreated, ADHD often leads to social and behavioral problems continuing in adulthood. [2][3][4] Effective treatment is possible using a combination of behavior management and stimulant medications. The high prevalence of ADHD provides a strong motivation to further refine the diagnosis and treatment, and to understand the etiology of this disorder.…”

Section: Introductionmentioning

confidence: 99%

Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder

et al. 2003

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Attention-deficit hyperactivity disorder (ADHD) is the most common childhood psychiatric disorder, affecting 5-10% of school-age children. Although the biological basis of this disorder is unknown, twin and family studies provide strong evidence that ADHD has a genetic basis involving multiple genes. A previous study found an association between ADHD and two polymorphisms in the 3 0 untranslated region (UTR) of SNAP-25, a gene encoding a synaptic vesicle docking protein known to play a role in the hyperactivity observed in the Coloboma mouse strain. In this paper, we test biased transmission of the 3 0 UTR SNAP-25 haplotype using a larger ADHD sample of 113 families with 207 affected children. Using the transmission disequilibrium test (TDT), we found a trend consistent with biased transmission of the TC haplotype of SNAP-25 in all transmissions and detected a significant distortion (P ¼ 0.027) when paternal transmissions were evaluated.

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Prevalence of Attention-Deficit/Hyperactivity Disorder and Conduct Disorder Among Substance Abusers

Cited by 263 publications

References 61 publications

EEG Biofeedback as a Treatment for Substance Use Disorders: Review, Rating of Efficacy and Recommendations for Further Research

EEG Biofeedback as a Treatment for Substance Use Disorders: Review, Rating of Efficacy and Recommendations for Further Research

Effects of major depressive disorder and attention-deficit/hyperactivity disorder on the outcome of treatment for cocaine dependence

Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder

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