Prevalence of atypical symptoms and their association with typical symptoms of gastroesophageal reflux in Spain

Rey, Enrique; Elola-Olaso, C. Moreno; Rodríguez‐Artalejo, Fernando; Locke, G. Richard; Dı́az-Rubio, Manuel

doi:10.1097/01.meg.0000230081.53298.03

Cited by 70 publications

(71 citation statements)

References 29 publications

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“…The symptom is characterized by the nonpainful sensation of a lump or foreign body in the throat [1], which is often encountered in otolaryngological practice. The etiology remains unclear, but gastroesophageal reflux [2][3][4], or upper esophageal sphincter (UES) hypertension [5][6][7], as well as psychological factors [8], have been proposed as causes of the sensation, although none of these has been confirmed.…”

Section: Introductionmentioning

confidence: 99%

Non-erosive reflux disease rather than cervical inlet patch involves globus

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Non-erosive reflux disease rather than cervical inlet patch involves globus

et al. 2010

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“…In recent years, a marked increase in the occurrence of the disease worldwide has been noted [1][2][3] . The approximate prevalence of GERD is 10-20% in Western populations [4,5] . It is commonly diagnosed based on typical symp- toms.…”

Section: Introductionmentioning

confidence: 99%

Gastroesophageal Reflux Disease: Work-Related Disease?

Pregun

Bakucz

Banai

et al. 2009

Dig Dis

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Background: An occupation-related susceptibility of professional singers to experience gastroesophageal reflux has been suggested. Aims: To investigate the prevalence of gastroesophageal reflux symptoms in a series of professional opera choristers, wind players, glassblowers and water polo players in comparison with a sample of general population. Subjects and Methods: A total of 202 professional opera choristers from well-known choirs in different Hungarian regions, 71 professional wind players, 43 glassblowers, 54 water polo players were identified and 115 control subjects were compared prospectively. Reflux symptoms together with selected individual characteristics and lifestyle habits were investigated in study groups through a reflux questionnaire. Results:Professional opera choristers reported a statistically significantly higher prevalence of heartburn, regurgitation and hoarseness than control subjects (p < 0.001). Among professional wind players, heartburn and regurgitation were significantly more frequent compared with controls (p < 0.05 and p < 0.01, respectively). Glassblowers reported a significantly higher prevalence of acid regurgitation in comparison with controls (p < 0.01). The prevalence of reflux symptoms in water polo players was similar to that of controls. In opera choristers, wind players and glassblowers, reflux symptoms appeared to be significantly correlated with the cumulative lifetime duration of professional singing, playing and working activity, respectively (p < 0.05). Conclusions: Our results demonstrate that professional opera choristers, professional wind players and glassblowers have a higher prevalence of reflux symptoms compared with control subjects. Gastroesophageal reflux in these professions should be considered as a work-related disorder that may have an impact on quality of life and may negatively interfere with professional performance.

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“…Also the atypical symptoms of GERD were closely correlated with the typical symptoms. [21] Unlike to Lee SP's study which showed that the scores of patients with symptomatic erosive esophagitis were higher than those of asymptomatic patients on all items of SCL-90-R, [22] we chose patients only with typical GERD symptom to compare with those with typical plus atypical GERD symptom. Our aim was to acquire more precise information about the relationship between mental disorder and GERD symptom.…”

Section: Discussionmentioning

confidence: 85%

The psychological results of 438 patients with persisting GERD symptoms by Symptom Checklist 90-Revised (SCL-90-R) questionnaire

2018

Medicine

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Persisting gastroesophageal reflux disease (GERD) symptoms affect mental state and social activities and mental disorders likewise play a crucial role on GERD symptoms. The aim of this study was to analyze the data of Symptom Checklist by 90-Revised (SCL-90-R) questionnaire in patients with persisting GERD symptom and to explore the impact of psychological factors on them.The patients accepted SCL-90-R questionnaire survey, following endoscopy, high-resolution manometry (HRM) and ambulatory impedance-pH monitoring. Based on these results, we divided patients into different groups. The result of SCL-90-R was also compared by degree of acid reflux, symptoms, symptom duration, and gender.The data from 438 patients were analyzed. All patients were divided into reflux esophagitis (RE) (63, 14.38%); nonerosive gastroesophageal disease (NERD) (106, 24.20%); functional heartburn (FH) (123, 28.08%), and hypersensitive esophagus (HE) (67, 15.29%); depression (DES) (5, 1.14%); hypertensive (10, 3.42%); weak peristalsis (14, 3.20%); achalasia (50, 11.42%). There were significant differences between varied groups judging by DEP, anxiety (ANX), paranoia ideation (PAR), psychoticism (PSY), and global severity index (GSI) domains (all P < .05). The patients with ≥2 years symptom duration presented more scores in DEP, ANX, and PSY (all P < .05). Compared to typical symptoms (n = 185), GERD typical plus atypical symptoms (n = 253) had higher scores of somatization (SOM), ANX, PSY and GSI (all P < .05). Women were found to have significantly higher scores than men in all domains (all P < .05).Our results find significant differences between varied patients with different diagnosis in DEP, ANX, PAR, PSY domains, and GSI. Long symptom duration, typical plus atypical symptoms, and female are more risky for psychological disorders.Abbreviations: ANX = anxiety, DEP = depression, DES = diffuse esophageal spasm, FH = functional heartburn, GERD = gastroesophageal reflux disease, GSI = global severity index, HE = hypersensitive esophagus, HOS = hostility, HRM = highresolution manometry, I-S = interpersonal sensitivity, NERD = nonerosive gastroesophageal disease, O-C = obsessive-compulsive behavior, PAR = paranoia ideation, PHOB = phobic anxiety, PPI = proton pump inhibitor, PSY = psychoticism, RE = reflux esophagitis, SCL-90-R = Symptom Checklist-90-R, SOM = somatization.

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Prevalence of atypical symptoms and their association with typical symptoms of gastroesophageal reflux in Spain

Abstract: The prevalence of atypical GER symptoms is extremely high. There is an association between typical and atypical GER symptoms, particularly chest pain, dysphagia, dyspepsia, belching and globus.

Cited by 70 publications

References 29 publications

Non-erosive reflux disease rather than cervical inlet patch involves globus

Non-erosive reflux disease rather than cervical inlet patch involves globus

Gastroesophageal Reflux Disease: Work-Related Disease?

The psychological results of 438 patients with persisting GERD symptoms by Symptom Checklist 90-Revised (SCL-90-R) questionnaire

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