Prevalence of Burkholderia cepacia recovered from clinical specimens in the Zainoel Abidin general hospital, Banda Aceh, Indonesia

Suhartono, Suhartono; Mahdani, Wilda; Muzayanna, Nyak Naiza

doi:10.18502/ijm.v15i1.11916

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…Severe underlying diseases, old age, prolonged bed rest, multiple organ failure, immune damage, prolonged antibiotic exposure, immunosuppressive agents, and invasive surgery are potential risk factors for bloodstream infections caused by B. cepacia . 3 , 6 , 13–15 ICU patients are at particularly high risk of B. cepacia bloodstream infection, and most strains were accordingly isolated from ICUs in the current study (173/49.57%), consistent with studies from other regions. 3 , 6 , 16 The route by which B. cepacia enters the blood system to cause infection is not fully understood.…”

Section: Discussionsupporting

confidence: 89%

Multicenter Investigation of Drug-Resistance in Burkholderia Cepacia Bloodstream Infections in Hebei Province, China, from 2016 to 2021

Liu,

Li,

Wen

et al. 2024

IDR

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Objective To compare the epidemiological characteristics and drug resistance of Burkholderia cepacia isolated from blood cultures, and to provide data support and a scientific basis for the clinical treatment and detection of hospital infections. Methods The Hebei Province Antimicrobial Surveillance Network received 349 B. cepacia strains isolated from blood cultures reported by 83 hospitals, from 2016 to 2021. These strains were identified by MALDI-TOF MS and, the antibiotic sensitivity tests were carried out using the VITEK 2 COMPACT system. The 2023 Institute of Clinical and Laboratory Standardization drug-susceptibility breakpoints were used for drug susceptibility testing and the data were analyzed using WHONET5.6 software. Results A total of 349 B. cepacia strains were isolated from 2016 to 2021, including 68 strains from secondary hospitals and 281 strains from tertiary hospitals. The ratios of male: female patients with B. cepacia bloodstream infections in all hospitals, secondary hospitals, and tertiary hospitals were 1.49:1 (209/140), 2.09:1 (46/22), and 1.38:1 (163/118), respectively. Most B. cepacia strains were isolated in intensive care units (ICUs), followed by internal medicine departments, accounting for 49.57% (173/349) and 22.92% (80/349), respectively. Regarding the age distribution, most patients were elderly (>65 years, 57.59%, 201/349), with numbers of patients gradually declining with decreasing of age. The resistance rates for levofloxacin, ceftazidime, and sulfamethoxazole decreased over the 6-year period (P<0.05), while there were no significant changes in the resistance rates for meropenem, chloramphenicol, and minocycline (P>0.05). There was no significant difference in drug-resistance rates between secondary and tertiary hospitals (P>0.05). Conclusion Attention should be paid to bloodstream infections caused by B. cepacia , especially elderly patients and patients admitted to the ICU. The difficult treatment characteristics of B. cepacia bloodstream infections mean that laboratories and clinicians should pay careful attention to drug resistance to provide a basis for their prevention and empirical treatment.

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Section: Discussionsupporting

confidence: 89%

Multicenter Investigation of Drug-Resistance in Burkholderia Cepacia Bloodstream Infections in Hebei Province, China, from 2016 to 2021

Liu,

Li,

Wen

et al. 2024

IDR

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Multidrug-Resistant Non-Fermenting Gram-Negative Bacilli Other Than P. Aeruginosa and A. Baumannii Complex Causing Infections at a Tertiary Care Hospital: A Therapeutic Concern

MITISHA SONI,

GARIMA SAIGAL,

DEEPTI CHAURASIA

et al. 2024

Asian J Pharm Clin Res

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Objective: This study aimed to identify the various unusual multidrug-resistant non-fermenting Gram-negative bacilli (MDR-NFGNB) other than Pseudomonas aeruginosa and Acinetobacter species isolated from the clinical specimens and to evaluate their antibiotic susceptibility pattern. Methods: This cross-sectional study conducted from January 2021 to June 2022 at a tertiary care teaching hospital identified unusual MDR NFGNB from clinical specimens using standard procedures and antibiotic susceptibility was done as per Clinical and Laboratory Standards Institute guidelines (including colistin susceptibility testing by broth microdilution). Results: A total of 523 unusual NF-GNB were isolated from 21,019 culture-positive clinical samples, of which 185 (35.3%) were MDR. Majority of these unusual NF-GNB isolated were from pus specimen (43.2%) followed by blood (22.7%). Out of 185 non-duplicate MDR non-fermenters, the most common were Acinetobacter lwoffii, Acinetobacter haemolyticus, Pseudomonas fluorescens, Pseudomonas putida, Pseudomonas stutzeri, Pseudomonas luteola, Stenotrophomonas maltophilia, Burkholderia cepacia, Elizabethkingia meningoseptica, Alcaligenes, Ralstonia pickettii, Sphingomonas, and Chryseobacterium indologenes. Conclusion: Any unusual NFGNB culture isolates from clinically significant infections should be correlated clinically for its pathogenic potential and identified using standard methods, to provide adequate and timely antibiotic coverage.

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Prevalence of Burkholderia cepacia recovered from clinical specimens in the Zainoel Abidin general hospital, Banda Aceh, Indonesia

Cited by 2 publications

References 26 publications

Multicenter Investigation of Drug-Resistance in Burkholderia Cepacia Bloodstream Infections in Hebei Province, China, from 2016 to 2021

Multicenter Investigation of Drug-Resistance in Burkholderia Cepacia Bloodstream Infections in Hebei Province, China, from 2016 to 2021

Multidrug-Resistant Non-Fermenting Gram-Negative Bacilli Other Than P. Aeruginosa and A. Baumannii Complex Causing Infections at a Tertiary Care Hospital: A Therapeutic Concern

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