Prevalence of canine cataract: preliminary results of a cross‐sectional study

Williams, David L.; Heath, M. F.; Wallis, Christopher J.D.

doi:10.1111/j.1463-5224.2004.00317.x

Cited by 53 publications

(47 citation statements)

References 16 publications

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“…This damage is thought to remain latent for some time, but eventually results in an earlier onset of aging and degenerative disease as well as increased rates of certain cancers. This theory is supported by the finding that adult giant breed dog cells have a lower proliferative capacity than those of other breeds (45), that large dogs tend to develop nonhereditary cataracts (thought to be due to accumulated oxidative damage) at an earlier age than small dogs (75), as well as the finding that dogs fed an energetically restricted diet tend to live longer than dogs fed a regular diet (38,43).…”

Section: Reduced Lifespan In Giant Breedssupporting

confidence: 67%

Lifespan and disease predispositions in the Irish Wolfhound: A review

Urfer¹,

Gaillard²,

Steiger³

2007

Veterinary Quarterly

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Section: Reduced Lifespan In Giant Breedssupporting

confidence: 67%

Lifespan and disease predispositions in the Irish Wolfhound: A review

Urfer¹,

Gaillard²,

Steiger³

2007

Veterinary Quarterly

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“…Their report thus gives a short mean life span in a list of all of the breeds covered and this may be because of the source material used, with the listing skewed by dogs dying early. Williams et al (2004) have reported a difference between three small and three medium size breeds in cataract prevalence with a higher percent of cataract in the larger breeds in this set of six entries, and they also noted an expected increase of cataracts with age in 2,000 individual dogs but without reference to their breed or size.…”

Section: Discussionmentioning

confidence: 99%

“…In this context, age-related cataract (ARC) is a pathological lesion that occurs with aging in humans, other mammals, and birds (Slatter et al 1983;Williams et al 2004;Wolf et al 2005;Zubenko et al 2007) and is at least partly linked to lens oxidative damage (Davies 1995;Spector 1995;Reddy et al 2001;Wolf et al 2005;Pendergrass et al 2006;Brennan and Kantorow 2009). We previously have shown a correlation between longevity in human nonagenarians and their delay in developing ARC (Zubenko et al 2007), and also demonstrated that small GH-R, IGF-1 deficient mutant dwarf mice have both delayed ARC development and extended life spans (Wolf et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Age-related cataract in dogs: a biomarker for life span and its relation to body size

Urfer

Greer

Wolf

2010

AGE

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Clinical data from 72 dog breeds of varying size and life expectancy were grouped according to breed body mass and tested for prevalence at ages 4 to 5, ages 7 to 10, and lifetime incidence of non-hereditary, age-related cataract (ARC). The incidence of ARC was found to be directly related to the relative life expectancies in the breed groups: The smallest dog breeds had a lower ARC prevalence between ages 4 and 5 than mid-size breeds and these, in turn, a lower prevalence than the giant breeds. A similar sequence was evident for ages 7 to 10 and for overall lifetime incidence of ARC. These differences became more significant when comparing small and giant breeds only. We could also confirm the inverse relationship between body size and life expectancy in these same sets of dog breeds. Our results show that body size, life expectancy, and ARC incidence are interrelated in dogs. Given that ARC has been shown to be at least partially caused by oxidative damage to lens epithelial cells and the internal lens, we suggest that it can be considered not only as a general biomarker for life expectancy in the canine and possibly other species, but also for the systemic damages produced by reactive oxygen species. This suggests new approaches to examine the gene expression pathways affecting the above-noted linkages.

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“…Cataract is a condition in the mammalian eye lens that appears to accompany the latter stages of lifespan in all mammals studied (e.g. Williams et al 2004;Fernandes et al 2003 andWolf et al 2000). Studies on humans have shown that cataract of the type brunnescent group IV is especially of major concern (Masters et al 1977).…”

Section: (Desportes Et Al 2003)mentioning

confidence: 99%

Two techniques of age estimation in cetaceans: GLGs in teeth and earplugs, and measuring the AAR rate in eye lens nucleus

Nielsen¹,

Víkingsson²,

Hansen³

et al. 2017

NAMMCOSP

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The ages of three species of cetaceans were estimated by counting the growth layer groups (GLG) and measuring the aspartic acid racemization rate (kAsp) by what is referred to as the Aspartic Acid Racemization (AAR) technique. Data on kAsp and the D/L ratio of aspartic acid at birth [(D/L)0] in North Atlantic common minke whales (Balaenoptera acutorostrata) are presented along with data on fin whales (B. physalus) and harbour porpoises (Phocoena phocoena) already published by Nielsen et al. (2012). The kAsp specific for minke whales was 1.40 x 10 -3 yr -1 (SE ± 0.00005) and the (D/L)0 was 0.0194 (SE ± 0.0012). The correlation of GLG age and D/L ratio for all three species was highly significant; however, the correlation coefficient varied greatly (fin whales: R 2 = 0.59, p <0.0001; minke whales: R 2 =0.96, P <0.0001; harbour porpoises: R 2 =0.36, P <0.0001). Asymptotic body length for all three species was estimated by a von Bertalanffy growth model on both the GLG and AAR techniques, and showed no difference.

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Prevalence of canine cataract: preliminary results of a cross‐sectional study

Abstract: The study yields novel findings regarding the prevalence and incidence of cataract in the dog and forms the basis for considerable further work on the epidemiology and pathophysiology of age-related cataract in the dog.

Cited by 53 publications

References 16 publications

Lifespan and disease predispositions in the Irish Wolfhound: A review

Lifespan and disease predispositions in the Irish Wolfhound: A review

Age-related cataract in dogs: a biomarker for life span and its relation to body size

Two techniques of age estimation in cetaceans: GLGs in teeth and earplugs, and measuring the AAR rate in eye lens nucleus

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