Prevalence of celiac disease among blood donors in SÃO PAULO – the most populated city in Brazil

Alencar, Marília Lage; Ortiz-Agostinho, Carmen Lucia; Nishitokukado, lêda; Damiao, Aderson O.; Abrantes-Lemos, Clarice Pires; Lamothe, André; Brito, Thales de; Chamone, Dalton de Alencar Fischer; Silva, Maria Elizabeth Rossi da; Giannella-Neto, Daniel; Sipahi, Aytan Miranda

doi:10.6061/clinics/2012(09)05

Cited by 33 publications

(34 citation statements)

References 34 publications

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“…This contrasts with the vast experience that is published on the subject, especially in countries such as Brazil (11) or Argentina (10) . Even though dyspepsia prevalence is much higher than the expected prevalence of CD in the general population, CD prevalence in Latin American countries has been shown to be comparable to the prevalence from North American or European countries (1) . As a consequence, our experience in this matter may be paralleled to the experiences in other regions of the World.…”

Section: Discussionmentioning

confidence: 99%

Celiac disease prevalence is not increased in patients with functional dyspepsia

Lasa¹,

Spallone²,

Gandara³

et al. 2017

Arq. Gastroenterol.

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-Background -Previous evidence trying to assess the risk of celiac disease among dyspeptic patients has been inconclusive, showing in some cases notorious discrepancies. Objective -To determine the prevalence of celiac disease in patients with dyspepsia compared to healthy controls without dyspepsia. Methods -Adult patients under evaluation for dyspepsia were invited to participate. These patients were offered an upper gastrointestinal endoscopy with duodenal biopsies. On the other hand, asymptomatic adult volunteers who performed a preventive visit to their primary care physician were invited to participate and agreed to undertake an upper gastrointestinal endoscopy with duodenal biopsies as well. Those patients with histologic signs of villous atrophy were furtherly evaluated and serological tests were performed in order to determine celiac disease diagnosis. Celiac disease prevalence was compared between groups. Results -Overall, 320 patients with dyspepsia and 320 healthy controls were recruited. There were no significant differences in terms of gender or age between groups. Celiac disease diagnosis was made in 1.25% (4/320) of patients in the dyspepsia group versus 0.62% (2/320) in the control group. Conclusion -Patients with dyspepsia who underwent routine duodenal biopsies did not show an increased risk for celiac disease when compared to healthy individuals. HEADINGS -Celiac disease. Dyspepsia. Endoscopy.

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Section: Discussionmentioning

confidence: 99%

Celiac disease prevalence is not increased in patients with functional dyspepsia

Lasa¹,

Spallone²,

Gandara³

et al. 2017

Arq. Gastroenterol.

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“…This study contained patients with clinical complaints, which is unusual for a seroprevalence study but has been described by other authors 32,37 . All patients reported abdominal pain (100%, p = 0.008), whereas only 40% complained of diarrhea, which is the classic symptom of the disease 1 .…”

Section: Characteristics Of Individuals With Positive Serology For Cementioning

confidence: 99%

“…A similar study conducted in São Paulo evaluated 4,000 serum samples from blood donors, and 24 showed positive serology: 11 were TTG-and EMA-positive, 10 were only TTG-positive and three were only EMA positive. Among the 21 patients who underwent duodenal biopsy, six (29%) patients had some histological abnormality 37 .…”

Section: Characteristics Of Individuals With Positive Serology For Cementioning

confidence: 99%

Prevalence and clinical features of celiac disease in patients with hepatitis B virus infection in Southern Brazil

Nau

Fayad

Lazzarotto

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Celiac disease is an autoimmune disorder that involves gluten intolerance and can be triggered by environmental factors including hepatitis B virus (HBV) infection. This study aimed to describe the prevalence of celiac disease in individuals with HBV infection and to describe the clinical and laboratory characteristics of celiac disease associated with HBV. Methods: This cross-sectional study included 50 hepatitis B patients tested for IgA anti-endomysial antibodies (EMAs) and tissue antitransglutaminase (TTG) between August 2011 and September 2012. Results: Fifty patients were included with a mean age of 46.0 ± 12.6 (46.0) years; 46% were female and 13% were HBeAg+. Six patients had positive serology for celiac disease, four were EMA+, and fi ve were TTG+. When individuals with positive serology for celiac disease were compared to those with negative serology, they demonstrated a higher prevalence of abdominal pain (100% vs. 33.3%, p = 0.008), lower median creatinine (0.7mg/dL vs. 0.9mg/dL, p = 0.007) and lower mean albumin (3.6 ± 0.4g/L vs. 3.9 ± 0.3g/L, p = 0.022). All individuals with positive serology for celiac disease underwent upper digestive endoscopy, and three of the patients exhibited a macroscopic pattern suggestive of celiac disease. Histologically, fi ve patients demonstrated an intra-epithelial lymphocytic infi ltrate level > 30%, and four patients showed villous atrophy associated with crypt hyperplasia on duodenal biopsy. Conclusions: An increased prevalence of celiac disease was observed among hepatitis B patients. These patients were symptomatic and had signifi cant laboratory abnormalities. These results indicate that active screening for celiac disease among HBV-infected adults is warranted.

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“…(5)(6)(7). En São Paulo la prevalencia de la enfermedad celíaca es del 0,6%, la cual es similar a las tasas reportadas en Portugal e Italia (5,7,8). Un diagnóstico positivo de la enfermedad celíaca se lleva a cabo por la presencia de transglutaminasa antitejido (tTG) y anticuerpos endomisiales (EMA) en los exámenes serológicos.…”

Section: Introductionunclassified

El efecto de la dieta libre de gluten en la alanina- aminotransferasa (ALT) en pacientes celíacos

Hatanaka

Silva

Dantas-Corrêa

et al. 2016

Rev. Colomb. Gastroenterol.

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El efecto de la dieta libre de gluten en la alaninaaminotransferasa (ALT) en pacientes celíacosThe effect of a gluten-free diet on alanine aminotransferase (ALT) in celiac patients ResumenIntroducción: la enfermedad celíaca es una enfermedad autoinmune provocada por la ingestión de gluten que afecta aproximadamente al 0,5%-1% de la población mundial. Las señales extraintestinales incluyen elevados niveles de alanina-aminotransferasa (ALT). Objetivo: evaluar los efectos de una dieta libre de gluten en los niveles ALT en pacientes con enfermedad celíaca. Métodos: este estudio transversal se llevó a cabo en la clínica ambulatoria de gastroenterología de un hospital universitario. Resultados: se incluyeron veintiséis pacientes con enfermedad celíaca con edad de 34,1 ± 11,4 años; 15,4% fueron hombres. Los sujetos del estudio tenían un nivel promedio de ALT de 54,6 ± 36,3 (mediana 40,5) U/L. Hubo una mayor proporción de individuos con hepatitis B en el grupo con ALT ≥50 U/L en comparación con sujetos con ALT <50 U/L. Entre los pacientes evaluados después del tratamiento con dieta libre de gluten se observó una reducción significativa de los valores de ALT (36,0 versus 31,0 U/l; p= 0,008). Conclusión: el treinta y cinco por ciento de los pacientes con enfermedad celíaca tenía ALT por encima del tercil superior. Se encontraron niveles más altos de ALT en pacientes con hepatitis viral B y en aquéllos que no se adhirieron a la dieta. Hubo una reducción de aminotransferasas como resultado de una dieta libre de gluten. Palabras claveTransaminasas, enfermedad celíaca, alanina-transaminasa, aminotransferasas aspartato, dieta, libre de gluten. AbstractIntroduction: Celiac disease is an autoimmune disease triggered by ingestion of gluten. It affects approximately 0.5% to 1% of the world population. Extra intestinal manifestations include elevated alanine aminotransferase (ALT) levels. Objective: The objective of this study was to evaluate the effects of a gluten-free diet on ALT levels in patients with celiac disease. Methods: This cross-sectional study was conducted in the gastroenterology outpatient clinic of a university hospital. Results: Twenty-six patients with celiac disease were included. Average patient age was 34.1 ± 11.4 years, and 15.4% of the patients were men. Study subjects had a mean ALT level of 54.6 ± 36.3 U/L (median 40.5). There was a higher proportion of individuals with hepatitis B in the group with ALT ≥ 50 U/L than in the group of subjects with ALT < 50 U/L. Among patients tested after treatment with a gluten-free diet, we observed a significant reduction in ALT values (36.0 vs. 31.0 U/L; P = 0.008). Conclusion: Thirty-five percent of celiac disease patients had ALT levels above the upper tertile. Higher ALT levels were found in patients with viral hepatitis B and in those who do not adhere to the diet. There was a reduction of aminotransferases with a gluten-free diet.

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Prevalence of celiac disease among blood donors in SÃO PAULO – the most populated city in Brazil

Cited by 33 publications

References 34 publications

Celiac disease prevalence is not increased in patients with functional dyspepsia

Celiac disease prevalence is not increased in patients with functional dyspepsia

Prevalence and clinical features of celiac disease in patients with hepatitis B virus infection in Southern Brazil

El efecto de la dieta libre de gluten en la alanina- aminotransferasa (ALT) en pacientes celíacos

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