Prevalence of Chronic Kidney Disease and Associated Factors among Patients with Diabetes in Northwest Ethiopia: A Hospital-Based Cross-Sectional Study

Alemu, Hailemaryam; Hailu, Workagegnehu; Adane, Aynishet

doi:10.1016/j.curtheres.2020.100578

Cited by 28 publications

(33 citation statements)

References 25 publications

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“…Of these reports, only those that described the data in terms of the odds ratio, relative risk, and categorical variables were included. In the present analysis, the pooled effect of four studies [ 31 , 51 , 53 , 54 ] showed that age greater than 60 years was statistically associated with CKD in patients with DM (OR = 2.99; 95% CI: 1.56, 5.73). The heterogeneity test ( I 2 = 53.4%) showed no significant evidence of variation across studies.…”

Section: Resultsmentioning

confidence: 54%

“…The number of study participants per study ranged from 189 to 700. The included studies applied various estimators of GFR; four of the studies [ 48 , 55 – 57 ] used the CG formula in estimating GFR, four studies [ 31 , 50 , 51 , 53 ] used the MDRD, and two studies [ 52 , 54 ] used the CKD-EPI creatinine equation. The prevalence of CKD in patients with DM was obtained from various regions in Ethiopia; four studies were from Amhara [ 50 , 51 , 53 ], three from Addis Ababa [ 55 – 57 ], three from Oromia [ 48 , 49 , 52 ], one each from Tigray [ 58 ] and SNNPR [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…The prevalence of CKD in patients with DM was obtained from various regions in Ethiopia; four studies were from Amhara [ 50 , 51 , 53 ], three from Addis Ababa [ 55 – 57 ], three from Oromia [ 48 , 49 , 52 ], one each from Tigray [ 58 ] and SNNPR [ 31 ]. With regard to the sampling technique, four studies [ 50 , 51 , 53 , 56 ] used systematic random sampling, three studies [ 31 , 57 , 58 ] used simple random sampling, two studies [ 52 , 54 ] used convenience sampling, and three studies [ 48 , 49 , 55 ] used the census sampling method. The quality score of the included studies was assessed based on the Newcastle–Ottawa quality score ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Based on this meta-analysis, chronic kidney disease among diabetes patients in the Ethiopian context was associated with the duration of DM, female sex, age >60 years, family history of CKD, BMI ≥30 kg/m 2 , type 2 diabetes, FBG >150 mg/dl, HbA1c >7%, HDL ≥40 mg/dl, triglyceride >150 mg/dl, and systolic blood pressure >140 mmHg [ 31 , 48 , 51 , 52 , 54 , 55 , 57 ].…”

Section: Resultsmentioning

confidence: 99%

“…Of these, only studies that reported data in terms of odds ratios, relative risks, and categorical variables were included. The pooled effects of two studies [ 54 , 56 ] showed that a habitual use of antipain therapy was nearly two times more likely to develop CKD in patients with DM than in patients who did not habitually use antipain therapy (OR = 1.59; 95% CI: 0.88, 2.87, I 2 = 0.0%), although this association was not statistically significant. In addition, clients who had current alcohol consumption practices had no significant difference in the development of CKD compared with those who could not consume alcohol (OR = 0.94; 95% CI: 0.29, 3.04, I 2 = 85.7%) ( Figure 6 ).…”

Section: Resultsmentioning

confidence: 99%

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Chronic Kidney Disease among Diabetes Patients in Ethiopia: A Systematic Review and Meta-Analysis

Shiferaw

Akalu

Aynalem

2020

International Journal of Nephrology

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Background. Though different primary studies have reported the burden of chronic kidney disease among diabetes patients, their results have demonstrated substantial variation regarding its prevalence in Ethiopia. Therefore, this study aimed to estimate the pooled prevalence of chronic kidney disease and its associated factors among diabetes patients in Ethiopia. Method. PubMed, African Journals Online, Google Scholar, Scopus, and Wiley Online Library were searched to identify relevant studies. The I2 statistic was used to check heterogeneity across the included studies. A random-effects model was applied to estimate the pooled effect size across studies. A funnel plot and Egger’s regression test were used to determine the presence of publication bias. All statistical analyses were performed using STATA™ version 14 software. Result. In this meta-analysis, a total of 12 studies with 4,075 study participants were included. The estimated prevalence of CKD among diabetes patients was found to be 35.52% (95% CI: 25.9–45.45, I2 = 96.3%) for CKD stages 1 to 5 and 14.5% (95% CI: 10.5–18.49, I2 = 91.1%) for CKD stages 3 to 5. Age greater than 60 years (OR = 2.99; 95% CI: 1.56–5.73), female sex (OR = 1.68; 95% CI: 1.04–2.69), duration of diabetes >10 years (OR = 2.76; 95% CI: 1.38–5.51), body mass index >30 kg/m2 (OR = 2.06; 95% CI: 1.41–3.00), type 2 diabetes (OR = 2.54; 95% CI: 1.73–3.73), poor glycemic control (OR = 2.01; 95% CI: 1.34–3.02), fasting blood glucose >150 mg/dl (OR = 2.58; 95% CI: 1.79–3.72), high density lipoprotein >40 mg/dl (OR = 0.48; 95% CI: 0.30–0.85–25), systolic blood pressure>140 mmHg (OR = 3.26; 95% CI: 2.24–4.74), and diabetic retinopathy (OR = 4.54; CI: 1.08–25) were significantly associated with CKD. Conclusion. This study revealed that the prevalence of chronic kidney disease remains high among diabetes patients in Ethiopia. This study found that a long duration of diabetes, age>60 years, diabetic retinopathy, female sex, family history of kidney disease, poor glycemic control, systolic blood pressure, overweight, and high level of high-density lipoprotein were associated with chronic kidney disease among diabetic patients. Therefore, situation-based interventions and context-specific preventive strategies should be developed to reduce the prevalence and risk factors of chronic kidney disease among diabetes patients.

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Section: Resultsmentioning

confidence: 54%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Chronic Kidney Disease among Diabetes Patients in Ethiopia: A Systematic Review and Meta-Analysis

Shiferaw

Akalu

Aynalem

2020

International Journal of Nephrology

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Assessment of renal impairment using estimated glomerular filtration rate among type 2 diabetes mellitus patients in North-East Ethiopia: a cross-sectional study

Taderegew

2020

J Diabetes Metab Disord

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Background Chronic kidney disease (CKD) is the known cause of morbidity and mortality among diabetes mellitus (DM) patients. Targeted screening of renal impairment based on estimated glomerular filtration rate (eGFR) among DM patients has potential benefits in early identification and treatment of CKD. Hence, this study was aimed to estimate the magnitude of renal impairment using eGFR among type 2 DM patients. Methods An institution-based cross-sectional study was conducted from February-1 to April 30/2020 among 422 type 2 DM patients in Northeast Ethiopia. Data were collected by the semi-structured questioner and serum creatinine measurement. The collected data were edited into Epi-data manager version 4.4.1.0, and the analysis was performed by SPSS-25. The Simplified Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology (CKD-EPI), and Cockcroft-Gault (C-G) equations were used to calculate eGFR. Results Of all study participants, 82(19.4%), 92(21.8%), and 103(24.4%) had eGFR < 60 ml/min/1.73 m2, according to the MDRD, CKD-EPI, and C-G equations, respectively. Female sex, (MDRD:AOR = 4.44, 95%CI:1.97–9.97, CKD-EPI:AOR = 3.17, 95%CI:1.27–6.17, and C-G:AOR = 2.65, 95%CI:1.35–5.21), duration ≥ 10 years (MDRD:AOR = 3.38, 95%CI:1.45–7.92, CKD-EPI:AOR = 3.09, 95%CI:1.07–7.77, and C-G:AOR = 2.92, 95%CI:1.29–6.61), age ˃60 years (MDRD:AOR = 2.29, 95%CI:1.09–4.77, CKD-EPI:AOR = 4.12, 95%CI:1.68–6.78, and C-G: AOR = 3.42, 95%CI:1.77–6.60), hypertension (MDRD:AOR = 3.12, 95%CI:1.51–6.45, CKD-EPI: AOR = 4.21,95%CI:2.07–7.98, and C-G:AOR = 3.99, 95%CI:2.08–7.65), poor glycemic control (MDRD:AOR = 2.82, 95%CI:1.13–7.05, and C-G:AOR = 2.34, 95%CI:1.09–5.04), and body mass index (MDRD:AOR = 1.11, 95%CI:1.01–1.22, and CKD-EPI:AOR = 2.43, 95%CI:1.27–5.76) were significantly associated with renal impairment. Conclusion Renal impairment was prevalent among type 2 DM patients. Older age, female sex, duration, hypertension, poor glycemic control, and BMI were significantly associated with renal impairment.

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The proportion of chronic kidney disease and its associated factors among adult diabetic patients at Tibebe Ghion Specialized Hospital, Bahir Dar, Ethiopia

et al. 2022

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Prevalence of Chronic Kidney Disease and Associated Factors among Patients with Diabetes in Northwest Ethiopia: A Hospital-Based Cross-Sectional Study

Cited by 28 publications

References 25 publications

Chronic Kidney Disease among Diabetes Patients in Ethiopia: A Systematic Review and Meta-Analysis

Chronic Kidney Disease among Diabetes Patients in Ethiopia: A Systematic Review and Meta-Analysis

Assessment of renal impairment using estimated glomerular filtration rate among type 2 diabetes mellitus patients in North-East Ethiopia: a cross-sectional study

The proportion of chronic kidney disease and its associated factors among adult diabetic patients at Tibebe Ghion Specialized Hospital, Bahir Dar, Ethiopia

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