Prevalence of Chronic Kidney Disease in US Adults with Undiagnosed Diabetes or Prediabetes

Plantinga, Laura C.; Crews, Deidra C.; Coresh, Josef; Miller, Edgar R.; Saran, Rajiv; Yee, Jerry; Hedgeman, Elizabeth; Pavkov, Meda E.; Eberhardt, Mark S.; Williams, Desmond E.; Powe, Neil R.

doi:10.2215/cjn.07891109

Cited by 342 publications

(253 citation statements)

References 27 publications

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“…Prediabetes is approximately twice as common as diabetes, affecting 20-35% of adults, and it progresses to diabetes in 45-50% of individuals after 10 years.P P 2,3 Prediabetes has been associated with CKD in cross-sectional studies, 4,5 but whether prediabetes predicts CKD in persons who do not develop diabetes is unclear. Longitudinal studies did not find prediabetes to be an independent risk factor for albuminuria or incident CKD, defined as an estimated GFR < 60 ml/min/1.73 m 2 .…”

Section: Discussionmentioning

confidence: 99%

Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study

Melsom

Schei

Stefansson

et al. 2016

American Journal of Kidney Diseases

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Section: Discussionmentioning

confidence: 99%

Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study

Melsom

Schei

Stefansson

et al. 2016

American Journal of Kidney Diseases

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“…First, the cross-sectional nature of NHANES may lead to misclassification of participants with CKD, because estimates of GFR and albuminuria were on the basis of single laboratory values. As in other research endeavors (27,28), lack of longitudinal data may have led to inclusion of individuals with acute kidney injury and not CKD. Second, awareness is selfreported and is subject to recall bias.…”

Section: Discussionmentioning

confidence: 99%

Chronic Kidney Disease Awareness Among Individuals with Clinical Markers of Kidney Dysfunction

Tuot

Plantinga

Hsu

et al. 2011

Clinical Journal of the American Society of Nephrology

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141

109

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SummaryBackground and objectives Awareness of chronic kidney disease (CKD) among providers and patients is low. Whether clinical cues prompt recognition of CKD is unknown. We examined whether markers of kidney disease that should trigger CKD recognition among providers are associated with higher individual CKD awareness.Design, setting, participants, & measurements CKD awareness was assessed in 1852 adults with an estimated GFR Ͻ60 ml/min per 1.73 m 2 using 1999 to 2008 National Health and Nutrition Examination Survey data. CKD awareness was a "yes" answer to "Have you ever been told you have weak or failing kidneys?" Participants were grouped by distribution of the following abnormal markers of CKD: hyperkalemia, acidosis, hyperphosphatemia, elevated blood urea nitrogen, anemia, albuminuria, and uncontrolled hypertension. Odds of CKD awareness associated with each abnormal marker and groupings of markers were estimated by multivariable logistic regression.Results Among individuals with kidney disease, only those with albuminuria had greater odds of CKD awareness (adjusted odds ratio, 4.0, P Ͻ 0.01) than those without. Odds of CKD awareness increased with each additional manifested clinical marker of CKD (adjusted odds ratio, 1.3, P ϭ 0.05). Nonetheless, 90% of individuals with two to four markers of CKD and 84% of individuals with Ն5 markers of CKD were unaware of their disease. ConclusionsAlthough individuals who manifest many markers of kidney dysfunction are more likely to be aware of their CKD, their CKD awareness remains low. A better understanding of mechanisms of awareness is required to facilitate earlier detection of CKD and implement therapy to minimize associated complications.

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“…The prevalence of overt proteinuria was 8% in those with diabetes and 3% among non-diabetic participants 1) . In a more recent NHANES survey from 1999 to 2006, the prevalence of CKD was 33% in those with diagnosed diabetes and 12% in those without diabetes 8) .…”

Section: Introductionmentioning

confidence: 99%

Statin Use in Patients with Diabetes and Kidney Disease: The Japanese Experience

Koya

Campese

2013

JAT

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Diabetes is a leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in developed nations, including Japan and the United States. Japan has the unenviable distinction of having one of the world's highest rates of dialysis: in 2011, there were over 300,000 dialysis patients (2,383 per million people), with diabetic patients accounting for almost half of all incident cases. Concomitance of CKD and diabetes predicts a greater risk of cardiovascular disease (CVD) than either condition in isolation. Hence, appropriate management of modifiable cardiovascular (CV) risk factors, including dyslipidemia, is paramount in this high-risk group. The United States and Japan have distinct approaches to cholesterol management, with more stringent therapeutic targets for lipid control advocated in US guidelines. However, upward trends in cholesterol levels and coronary heart disease incidence in Japan may provide justification for more intensive CV risk factor management strategies by Japanese physicians to achieve maximum benefit. Attainment of recommended lipid goals in Japan is poor, particularly in patients with diabetes and/or CKD in whom CV risk factors are often undertreated. Statin therapy has been shown to be safe and effective in reducing CV risk in patients with diabetes and/or CKD stages 1-5. Moreover, statins may impart a renoprotective effect by preventing or delaying progressive loss of kidney function. This review summarizes evidence from studies in Western and Japanese populations to highlight the CV and renal benefits of lipid-lowering agents in CKD patients, including those with diabetes. J Atheroscler

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Prevalence of Chronic Kidney Disease in US Adults with Undiagnosed Diabetes or Prediabetes

Cited by 342 publications

References 27 publications

Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study

Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study

Chronic Kidney Disease Awareness Among Individuals with Clinical Markers of Kidney Dysfunction

Statin Use in Patients with Diabetes and Kidney Disease: The Japanese Experience

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