Prevalence of clinical and electrocardiographic evidence of ischaemic heart disease in the older population.

Kitchin, A. H.; Lowther, Clifton P.; Milne, John

doi:10.1136/hrt.35.9.946

Cited by 33 publications

(18 citation statements)

References 24 publications

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“…Kitchin et al (1973), whose study of old people at home closely resembles the present investigation, failed to find such an association, but prospective data from the Framingham survey, reported by Kannel (1976), suggests that cigarette smoking retains its place as a risk factor for ischaemic heart disease in old age. Kannel also stresses the importance of high blood pressure as a risk factor for ischaemic heart disease in old age, but this is not confirmed either by Kitchin et al (1973) or by the present study; both of these include many subjects over the age of 75 years. Neither blood glucose nor serum cholesterol level are associated with the presence of ischaemic heart disease (Fig.…”

Section: Discussionsupporting

confidence: 53%

“…But the electrocardiogram was normal in 7 of the 23 (30%) in whom the criterion for the diagnosis of ischaemic heart disease was a documented cardiac infarct. The findings of Kitchin et al (1973) in the elderly are very similar. Of the 107 subjects in the present study in whom ischaemic heart disease was diagnosed and an electrocardiogram recorded, 43 per cent had Q/QS abnormalities, 30 per cent had other codable abnormalities, and 25 per cent had a normal electrocardiogram.…”

Section: Discussionsupporting

confidence: 52%

“…Male sex is a most important risk factor for ischaemic heart disease in the young and middle aged (Joint Working Party, 1976), but, as Table 5 shows, this is not so in the elderly, in whom the prevalence rate in men exceeds that in women by only 10 to 20 per cent (Kitchin et al, 1973).…”

Section: Discussionmentioning

confidence: 99%

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Ischaemic heart disease in the elderly.

Kennedy¹,

Andrews²,

Caird³

1977

Heart

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Studies were made for evidence of heart disease on 501 people aged 65 and more living at home; 22-4 per cent had clinical and/or electrocardiographic evidence of ischaemic heart disease. The prevalence of ischaemic heart disease increased with age, and was slightly greater in men than women. The frequency of ischaemic heart disease increased with increasing current cigarette consumption and with total cigarette consumption. There was no increase in relation to any of the following possible risk factors: systolic and diastolic blood pressure, blood glucose, serum cholesterol, skinfold thickness, percentage of ideal body weight. The survival over a 5-year period of all subjects with ischaemic heart disease did not differ significantly from that of all subjects together, but the mortality of subjects with ischaemic heart disease and an abnormal electrocardiogram was 1-5 to 2 times that of subjects in whom ischaemic heart disease was diagnosed on the basis of angina pectoris or past cardiac infarction, the electrocardiogram being normal.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionsupporting

confidence: 52%

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Ischaemic heart disease in the elderly.

Kennedy¹,

Andrews²,

Caird³

1977

Heart

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“…In addition an overall incidence of toxicity of 5.8% for digitoxin (Storstein et al, 1977) is considerably lower than the 21% for digoxin found by Evered & Chapman (1971). Since digitalis therapy is invaluable in certain conditions such as fast atrial fibrillation which is present in 2.5% of the population over 60 years (Kitchin, Lowther & Milne, 1973) and digoxin use in the elderly is often unsatisfactory, digitoxin may be a preferable choice. However there are no formal studies of the effects of ageing on digitoxin kinetics and so the present study was undertaken.…”

Section: The Effect Of Age On Digitoxin Pharmacokineticsmentioning

confidence: 99%

The effect of age on digitoxin pharmacokinetics.

Donovan¹,

Castleden²,

Pohl³

et al. 1981

Brit J Clinical Pharma

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“…In an earlier paper we reported (Kitchin et al, 1973) on the prevalence of various manifestations of ischaemic heart disease in 487 subjects aged 62 to 90 who formed a randomly selected sample of the 27 000 older people living in a defined area of Edinburgh. Briefly this showed that 10 per cent gave a history of angina; 44 per cent had no codable electrocardiographic abnormality, 6 per cent had electrocardiographic abnormalities strongly suggestive of ischaemic heart disease, and a further 24 per cent had changes possibly caused by ischaemic heart disease.…”

mentioning

confidence: 99%

Longitudinal survey of ischaemic heart disease in randomly selected sample of older population.

Kitchin¹,

Milne²

1977

Heart

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A group of 215 men and 272 women aged 62 to 90foming a randomly-selected sample of the older population was studied by cardiovascular survey methods andfollowedfor 5 years. The 5-year mortality of 28 per cent was related to age and was higher in men. Ischaemic heart disease was the certified cause of 28 per cent of the deaths. Mortality was greater in those with systolic hypertension. Among electrocardiographic features ST depression, T inversion, and atrial fibrillation increased overall and ischaemic heart disease mortality independently of their association with age. A positive response to an angina and infarct questionnaire was poorly related to subsequent mortality.Re-examination of 72 per cent of 5-year survivors was possible. Systolic and diastolic blood pressures were significantly lower and the frequency of electrocardiographic abnormalities, particularly left axis deviation, left ventricular hypertrophy, and ST and T wave changes, was increased.

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Prevalence of clinical and electrocardiographic evidence of ischaemic heart disease in the older population.

Cited by 33 publications

References 24 publications

Ischaemic heart disease in the elderly.

Ischaemic heart disease in the elderly.

The effect of age on digitoxin pharmacokinetics.

Longitudinal survey of ischaemic heart disease in randomly selected sample of older population.

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