Prevalence of Coeliac Disease in Patients with Thyroid Autoimmunity

Valentino, Rossella; Savastano, Silvia; Tommaselli, A; Dorato, M.; Scarpitta, M; Gigante, Marianna; Micillo, Maria; Paparo, Francesco; Petrone, Emma; Lombardi, Gaetano; Troncone, Riccardo

doi:10.1159/000023344

Cited by 79 publications

(69 citation statements)

References 15 publications

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“…Additionally, in our study, the prevalence rate of CD in patients with AT was higher than in the previous studies (mean value 3.7%) [11][12][13][14] . This might be associated with the higher prevalence rate of CD in Turkish population.…”

Section: Discussioncontrasting

confidence: 80%

“…An increased prevalence of coeliac disease has been found in patients with AT and Graves' disease [11][12][13][14] . Moreover, it has been demonstrated that many coeliacs are prone to autoimmune thyroid dysfunction [18,19] .…”

Section: Discussionmentioning

confidence: 99%

“…It is of great importance to identify early CD in patients with AT, since a strict adherence to a gluten-free diet not only helps prevent the severe complications of untreated gluten-sensitive enteropathy such as ulcerative jejunoileitis, intestinal lymphoma and neoplasm [22] , but also helps improve the associated autoimmune disease [12] . This is the first study conducted about association of CD with AT in a Turkish population.…”

Section: Discussionmentioning

confidence: 99%

“…I t i s k n ow n t h a t C D i s a s s o c i a t e d w i t h s o m e autoimmune disorders, especially type-Ⅰdiabetes mellitus, autoimmune thyroid diseases, collagen disorders, Addison' s disease, pernicious anaemia, alopecia and autoimmune hepatitis [8][9][10] . Among adult patients with autoimmune thyroiditis, the prevalence of CD has been reported to be 3.3-4.8 times more than in the general population [11][12][13][14] . In contrast, a study reported a CD prevalence of 0% in patients with autoimmune thyroiditis [15] .…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of coeliac disease in patients with autoimmune thyroiditis in a Turkish population

Güliter

Yakaryılmaz²,

Ersoy³

et al. 2007

WJG

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Section: Discussioncontrasting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of coeliac disease in patients with autoimmune thyroiditis in a Turkish population

Güliter

Yakaryılmaz²,

Ersoy³

et al. 2007

WJG

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“…In a previous study (10) we used an endomysial antibody to screen 150 patients with autoimmune thyroid disease; five showed a positive serology and were diagnosed as coeliacs on the basis of the jejunal biopsy. The aim of this paper was to look for signs of minor small bowel injury and immunohistochemical markers of gluten sensitivity in a group of ATD patients, in particular patients with Hashimoto's thyroiditis, without serological markers of CD.…”

Section: Introductionmentioning

confidence: 99%

Markers of potential coeliac disease in patients with Hashimoto's thyroiditis

Valentino¹,

Savastano

Maglio³

et al. 2002

Eur J Endocrinol

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Objective: Coeliac disease (CD) is associated with autoimmune thyroid disease. Gluten sensitivity represents a spectrum, with at one end cases with severe gluten-dependent enteropathy, and at the other subjects with minor signs of deranged mucosal immune response. The aim of this paper was to look for signs of minor small bowel injury and immunohistochemical markers of gluten sensitivity in a group of patients with Hashimoto's disease. Subjects and methods: Fourteen patients with Hashimoto's thyroiditis without serological evidence of CD underwent immunohistochemical analysis of jejunal biopsies. Results: In 6/14 cases (43%) an increased density of gd T cell receptor bearing intra-epithelial lymphocytes was found. In 6/14 (43%) signs of mucosal T cell activation (presence of interleukin 2 (IL2) receptor (CD25) on lamina propria T cells and/or expression of human lymphocyte antigen (HLA)-DR molecules on crypt epithelial cells) were noted. In 4 out of 6 such cases, HLA haplotypes were described in association with CD. Conclusion: A significant proportion of patients with Hashimoto's thyroiditis present signs of 'potential' CD and of activated mucosal T cell immunity. The gluten dependence of such findings remains to be ascertained.

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Guideline for the Diagnosis and Treatment of Celiac Disease in Children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

Hill,

Dirks,

Liptak

et al. 2005

J. pediatr. gastroenterol. nutr.

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Celiac disease is an immune‐mediated enteropathy caused by a permanent sensitivity to gluten in genetically susceptible individuals. It occurs in children and adolescents with gastrointestinal symptoms, dermatitis herpetiformis, dental enamel defects, osteoporosis, short stature, delayed puberty and persistent iron deficiency anemia and in asymptomatic individuals with type 1 diabetes, Down syndrome, Turner syndrome, Williams syndrome, selective immunoglobulin (Ig)A deficiency and first degree relatives of individuals with celiac disease. The Celiac Disease Guideline Committee of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition has formulated a clinical practice guideline for the diagnosis and treatment of pediatric celiac disease based on an integration of a systematic review of the medical literature combined with expert opinion.The Committee examined the indications for testing, the value of serological tests, human leukocyte antigen (HLA) typing and histopathology and the treatment and monitoring of children with celiac disease. It is recommended that children and adolescents with symptoms of celiac disease or an increased risk for celiac disease have a blood test for antibody to tissue transglutaminase (TTG), that those with an elevated TTG be referred to a pediatric gastroenterologist for an intestinal biopsy and that those with the characteristics of celiac disease on intestinal histopathology be treated with a strict gluten‐free diet. This document represents the official recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition on the diagnosis and treatment of celiac disease in children and adolescents.

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Prevalence of Coeliac Disease in Patients with Thyroid Autoimmunity

Cited by 79 publications

References 15 publications

Prevalence of coeliac disease in patients with autoimmune thyroiditis in a Turkish population

Prevalence of coeliac disease in patients with autoimmune thyroiditis in a Turkish population

Markers of potential coeliac disease in patients with Hashimoto's thyroiditis

Guideline for the Diagnosis and Treatment of Celiac Disease in Children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

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