Prevalence of coeliac disease in Italian patients affected by Addison's disease

Biagi, Federico; Campanella, Jonia; Soriani, A.; Vailati, A; Corazza, Gino Roberto

doi:10.1080/00365520500206517

Cited by 23 publications

(7 citation statements)

References 28 publications

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“…Histological result would enable to classify these individuals as 'silent' (with typical mucosal lesions but no symptoms) or 'latent' (with normal appearance of intestinal mucosa) celiac disease. Data from our study confirm higher prevalence of celiac disease in AAD patients; however, the proportion of affected subjects (3.5%) is lower in comparison to other European series (5.9-12.2%) [40][41][42][43]. Only one former report stated lower frequency of celiac disease, among Dutch AAD patients (1.2%), but the diagnostic criteria were not provided [12].…”

Section: Discussioncontrasting

confidence: 58%

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Screening for associated autoimmune disorders in Polish patients with Addison’s disease

Fichna

Gryczyńska

et al. 2010

Endocr

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Autoimmune Addison's disease (AAD) is the main reason of primary adrenal failure. More than a half of patients display additional autoimmune conditions, which represent a considerable clinical concern. This study aimed to investigate the prevalence of concomitant autoimmune disorders in 85 Polish AAD patients (61 females, 24 males). Mean age at AAD onset was 34.6 ± 12.6 years, significantly earlier in males (P < 0.001). Sixty-nine patients presented positive serum antibodies to 21-hydroxylase and shorter AAD duration than those with negative results (P = 0.027). Seventy-three subjects suffered from coexisting autoimmune disorders. Serum autoantibodies against thyreoperoxidase, thyroglobulin, TSH receptor, glutamic acid decarboxylase, insulin, tyrosine phosphatase-like protein IA2, parietal cell H(+)/K(+)-ATPase, intrinsic factor and tissue transglutaminase were detectable in 71.8, 41.2, 4.7, 21.0, 4.9, 2.5, 49.4, 12.0 and 3.5% of patients, respectively. Antinuclear antibodies were found in 12.5%. Thyroid autoimmunity was most common (46 subjects with lymphocytic thyroiditis, 19 with Graves' disease), followed by atrophic gastritis (29.4%), pernicious anaemia (11.8%), hypergonadotropic hypogonadism (8.2%), vitiligo (8.2%), type 1 diabetes (7.1%), celiac disease (3.5%) and alopecia (2.4%). Gender differences were observed only for thyroid autoimmunity. Current study confirms particular tendency of AAD patients to develop other autoimmune disorders. Active search for concomitant conditions is warranted to prevent serious complications.

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Section: Discussioncontrasting

confidence: 58%

“…Studies in other European cohorts revealed high frequency of celiac disease among AAD patients compared to the general population [39][40][41][42]. Moreover, increasing proportion of celiac disease cases remains asymptomatic for a long time.…”

Section: Discussionmentioning

confidence: 99%

Screening for associated autoimmune disorders in Polish patients with Addison’s disease

Fichna

Gryczyńska

et al. 2010

Endocr

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“…Other than type 1 diabetes and thyroid autoimmune diseases, further endocrine conditions, such as Addison’s disease [ 87 ] and primary hyperparathyroidism [ 88 ], together with a substantial number of additional immune-mediated disorders [ 89 ] have been reported in association with CD. These include rheumatic and connective tissue diseases, i.e.…”

Section: Associated Diseasesmentioning

confidence: 99%

The Spectrum of Differences between Childhood and Adulthood Celiac Disease

et al. 2015

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An old saying states that ‘’children are not little adults” and this certainly holds true for celiac disease, as there are many peculiar aspects regarding its epidemiology, diagnosis, clinical presentations, associated diseases, and response to treatment in pediatric compared to adult populations, to such an extent that it merits a description of its own. In fact, contrary to the past when it was thought that celiac disease was a disorder predominantly affecting childhood and characterized by a malabsorption syndrome, nowadays it is well recognized that it affects also adult and elderly people with an impressive variability of clinical presentation. In general, the clinical guidelines for diagnosis recommend starting with specific serologic testing in all suspected subjects, including those suffering from extraintestinal related conditions, and performing upper endoscopy with appropriate biopsy sampling of duodenal mucosa in case of positivity. The latter may be omitted in young patients showing high titers of anti-transglutaminase antibodies. The subsequent management of a celiac patient differs substantially depending on the age at diagnosis and should be based on the important consideration that this is a lifelong condition.

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“…Adrenal cortex autoantibodies or 21-hydroxylase autoantibodies are present in more than 90% of patients at the onset of the disease [82]. The prevalence of CS in patients with Addison’s disease is 5–12% [83–86]. Conversely, in a cohort of 14,366 Swedish CS patients, 0.25% of CS patients had Addison’s disease compared with 0.02% of controls (HR: 11.4; 95% CI: 4.4–29.6).…”

Section: Autoimmune Diseases Associated With Csmentioning

confidence: 99%

Celiac sprue: a unique autoimmune disorder

Rashtak

Marietta

Murray³

2009

Expert Review of Clinical Immunology

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Celiac sprue (CS) is a gluten-sensitive enteropathy with many autoimmune features. CS involves multiple organs through immune and nonimmune processes, and is frequently associated with other autoimmune disorders. This article reviews the co-occurrence of CS with autoimmune disorders of the cutaneous, nervous, endocrine, musculoskeletal, gastrointestinal and cardiovascular systems. The types of autoimmune disorders associated with CS and the prevalence of CS in other autoimmune disorders are also discussed. A brief review of the literature on the potential mechanisms behind these associations and the therapeutic effects of a gluten-free diet for autoimmune comorbidities in CS is also provided.

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Prevalence of coeliac disease in Italian patients affected by Addison's disease

Cited by 23 publications

References 28 publications

Screening for associated autoimmune disorders in Polish patients with Addison’s disease

Screening for associated autoimmune disorders in Polish patients with Addison’s disease

The Spectrum of Differences between Childhood and Adulthood Celiac Disease

Celiac sprue: a unique autoimmune disorder

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