Prevalence of Congenital Hypothyroidism in Neonates

Abstract

Objective: To determine the frequency of congenital hypothyroidism in neonates. Patients and Methods: A total number of 200 neonates born through SVD and cesarean section after 37 weeks of gestation aged 48 hours of birth to 2 weeks of neonatal age (as serum of neonates less than 48 hours of life contain mother’s serum level of TSH were included. The study was conducted from 05-Nov-2020 to 04-May-2021. Data regarding neonates’ age, gender, weight, and height was taken. 2cc venous blood was taken for serum TSH and T4 level. Neonates having TSH hormone level more than 20mIU/mL were labelled as having congenital hypothyroidism (CH). Results: Mean age of neonates was 9.63±3.94 days. There were 113 (56.50%) females and 87 (43.50%) male neonates. Mean weight of neonates was 2970.28±516.32 grams. Mean height of neonates was 52.23±2.11 cm. Mean gestational age was weeks. Mean occipitofrontal circumference of neonates was 34.69±1.29 cm. Mean TSH level were 6.64±7.92 mIU/L. Mean T4 level was 23.70±4.25 µg/dL. CH was diagnosed in 4 (2.0%) neonates. Conclusion: Congenital hypothyroidism (CH) is common among neonates. In present study CH was diagnosed in 2.0% neonates who were screened for CH. So CH screening should be done in all neonates to diagnose CH at early stages and to prevent complication of CH in these neonates. Keywords: Thyroid Stimulating Hormone (TSH), Congenital Hypothyroidism (CH),