Prevalence of congenital malformations at the “les Orangers” maternity and reproductive health Hospital of Rabat: descriptive study of 470 anomalies

Abstract

Background: Congenital malformations are described in about 3% of live births and 20% of stillbirths in the industrialized countries. The prevalence of congenital anomalies in developing countries, including Morocco, is not well known at the national level. The aim of our study is to conduct a descriptive exploratory analysis of congenital malformations cases diagnosed at the "Les Orangers" Maternity and Reproductive Health Hospital in Rabat. Methods: We collected all the cases of congenital malformations diagnosed at the "Les Orangers" Maternity and Reproductive Health Hospital in Rabat, from January 1st, 2011 to June 31st, 2016. Data were reported on pre-established sheets and on a registry of malformations. Total and specific prevalences were calculated for each malformation. A principal component analysis (PCA) was then conducted followed by a Varimax rotation in order to identify the different associations of malformations in our series. Results: We registred 245 cases of congenital malformations out of a total of 43,923 recorded births; a prevalence of 5.58 per thousand births of which 19.2% were FDIU (fetal deaths in utero). A polymalformative syndrome was found in 26.5% of cases which makes a total number of 470 anomalies. The musculoskeletal anomalies predominate with a rate of 33%, followed by neurological abnormalities 18%, of whom 31% were hydrocephalus, 26.2% anencephaly, and 20.24% spina bifida. Malformations of the eye, ear, face and neck were described in 12% of the cases, while genetic abnormalities were observed in 8,5% of which 87.5% represented Down syndrome. The antenatal diagnosis of congenital malformations was performed in 28.6% of cases. Conclusions: Our study provides a general overview of the epidemiological situation related to different types of congenital anomalies for a specific area in Morocco. It represents a database that should be complemented by other multicenter studies and the implementation of a

Proportion of Chromosomal Disorders and Their Patterns among Births with Congenital Anomalies in Africa: A Systematic Review and Meta-Analyses

“…In this systematic review and meta-analysis, 60 articles, which included about 3,091,946 births and 52,569 congenital anomalies, were analyzed. Of these, 4 studies were conducted in Ethiopia [ 30 – 33 ]; 16 studies were conducted in Nigeria [ 34 – 48 ]; 9 studies were conducted in Egypt [ 49 – 59 ]; 3 studies were conducted in South Africa [ 60 – 64 ]; 5 studies were conducted in Morocco [ 65 – 69 ]; 6 studies were conducted in Libya [ 70 – 75 ]; 2 studies were conducted in Tunisia [ 76 – 79 ]; and 7 studies were conducted in Mozambique [ 80 ], Botswana [ 81 ], Cameroon [ 82 ], the DRC [ 83 ], Malawi [ 84 ], Zambia [ 85 ], Gabon [ 86 ], and Uganda [ 87 ]. Two studies were from Sudan [ 88 , 89 ].…”

“…In this systematic review and meta-analysis, 60 articles, which included about 3,091,946 births and 52,569 congenital anomalies, were analyzed. Of these, 4 studies were conducted in Ethiopia [30][31][32][33]; 16 studies were conducted in Nigeria [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]; 9 studies were conducted in Egypt [49][50][51][52][53][54][55][56][57][58][59]; 3 studies were conducted in South Africa [60][61][62][63][64]; 5 studies were conducted in Morocco [65][66][67][68][69]; 6 studies were conducted in Libya [70][71][72][73][74][75]; 2 studies were conducted in Tunisia [76][77]…”

“…In this systematic review and meta-analysis, the authors merged “others” and unclassified chromosomal anomalies” into “unclassified chromosomal disorders.” Ten studies ( n = 10) out of 60 included articles were reported the prevalence of unclassified chromosomal disorders among births with congenital anomalies. The pooled proportion of unclassified chromosomal disorders ranged from 0.81% [ 65 ] to 8.1% [ 48 ]. The random-effects model analysis from these studies revealed that the pooled proportion of unclassified chromosomal disorders among births with congenital anomalies in Africa was found to be 1.78% (95% CI: 0.97, 2.60; I 2 = −; p =0.36) ( Figure S8 ).…”

A Retrospective Analysis of the Spectrum of Congenital Malformations Diagnosed Prenatally Based on the Lviv Medical Genetics Center during 2018-2020 yy

“…Антенатальну діагностику природжених вад розвитку проведено у 28,6 % випадків, решту діагностовано після пологів, із них 19,2 % становили мертвонародження [11], що свідчить про недоступність пренатальної діагностики для багатьох верств населення країн, що розвиваються, на відміну від України та інших країн Європи.…”

The challenges of severe laparoschisis management in rural health facilities: a case from Bominenge health district facility

“…Laparoschisis 1 is 'a congenital malformation characterized by the absence of the abdominal covering sac and/or sub-cutaneous and cutaneous tissues, exposing viscera to the external environment'. Previous research [1][2][3][4][5][6][7] reported a moderate prevalence of 1 per 6,000 births in Europe and 4.4 per 10,000 births in Canada, While the disease has not been extensively studied in Africa, results from facility-based studies [8][9][10] suggest that laparoschisis represents between 5-12% of total congenital malformations diagnosed in West and Northern Africa. The authors'article1 also reported that it occurs around teen weeks of gestational age and results in bowel protruding without covering sac, adding that antenatal diagnosis is rare due to the lack of antenatal optimal investigation, mainly ultrasound in rural health care facilities.…”