Prevalence of daily medication adherence among children with sickle cell disease: A 1‐year retrospective cohort analysis

Patel, Niti G.; Lindsey, Terianne; Strunk, Robert C.; DeBaun, Michael R.

doi:10.1002/pbc.22605

Cited by 43 publications

(55 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a study of Medicaid-insured children from 2 states, Cox et al found that only 41% of days were covered with an antibiotic prescription, and only 22% of children had 75% or more days covered in a year, 15 slightly lower than our measured adherence. In other Medicaid-insured populations of children with SCD, Patel et al found 55% coverage for antibiotics, which was similar to the compliance observed in the same population for other medications (range: 59–61%), 16 and Beverung et al observed a mean of 45% of days covered with antibiotics, with fewer than 1 in 5 children meeting their full adherence threshold of 80%. 17 …”

Section: Discussionmentioning

confidence: 52%

Preventive Care Delivery to Young Children With Sickle Cell Disease

Bundy

Muschelli

Clemens

et al. 2016

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

Preventive services can reduce the morbidity of sickle cell disease (SCD) in children but are delivered unreliably. We conducted a retrospective cohort study of children ages 2–5 years with SCD, evaluating each child for 14 months and expecting that he/she should receive ≥75% of days covered by antibiotic prophylaxis, ≥1 influenza immunization, and ≥1 transcranial Doppler ultrasound (TCD). We used logistic regression to quantify the relationship between ambulatory generalist and hematologist visits and preventive services delivery. Of 266 children meeting inclusion criteria, 30% consistently filled prophylactic antibiotic prescriptions. Having ≥2 generalist, non-well child care visits or ≥2 hematologist visits was associated with more reliable antibiotic prophylaxis. Forty-one percent of children received ≥1 influenza immunizations. Children with ≥2 hematologist visits were most likely to be immunized (62% versus 35% among children without a hematologist visit). Only 25% of children received ≥1 TCD. Children most likely to receive a TCD (42%) were those with ≥2 hematologist visits. One in twenty children received all three preventive services. Preventive services delivery to young children with SCD was inconsistent but associated with multiple visits to ambulatory providers. Better connecting children with SCD to hematologists and strengthening preventive care delivery by generalists are both essential.

show abstract

Section: Discussionmentioning

confidence: 52%

Preventive Care Delivery to Young Children With Sickle Cell Disease

Bundy

Muschelli

Clemens

et al. 2016

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

show abstract

“…In spite of the known benefit, the penicillin adherence rates in most studies were less than 80 % [14][15][16][17][18][19]. Our personal experiences regarding HU in the clinic indicated a similarly low figure.…”

Section: Discussionmentioning

confidence: 89%

Adherence to hydroxyurea medication by children with sickle cell disease (SCD) using an electronic device: a feasibility study

Inoue

Kodjebacheva

et al. 2016

Int J Hematol

View full text Add to dashboard Cite

Adherence to hydroxyurea (HU) is a significant modifying factor in sickle cell vaso-occlusive pain. We conducted a study using an electronic medication container-monitor-reminder device (GlowCap™) to track adherence and determine whether use of this device affected rates of HU adherence. Subjects were regular attendees to our clinic. They were given a 37-item questionnaire and were asked to use a GlowCap containing HU. When the device cap is opened, it makes a remote "medication taken" record. The device also provides usage reminder in the form of lights and alarm sounds if the cap opening is delayed. Nineteen subjects participated in the survey, and 17 in the intervention phase. Of the 17, 12 had reliable adherence data. Seventeen caregivers of patients and two patients completed the survey. Two most common barriers to adherence identified were lack of reminders and absence of medicine home delivery. The intervention component of this study, which used both the electronic (GlowCap) method and medication possession ratio showed that the median adherence rate for the 12 patients evaluated was 85 %. The GlowCap device accurately kept a record of adherence rates. This device may be an effective tool for increasing HU medication adherence.

show abstract

“…Only 1 article compared adherence to different types of medications for SCD and found similar rates of adherence for hydroxyurea (mean MPR 60%), folic acid (mean MPR 61%), and penicillin (mean MPR 55%). 28 …”

Section: Adherence Ratesmentioning

confidence: 99%

Medication Adherence Among Pediatric Patients With Sickle Cell Disease: A Systematic Review

et al. 2014

View full text Add to dashboard Cite

OBJECTIVES: Describe rates of adherence for sickle cell disease (SCD) medications, identify patient and medication characteristics associated with nonadherence, and determine the effect of nonadherence and moderate adherence (defined as taking 60%-80% of doses) on clinical outcomes. METHODS:In February 2012 we systematically searched 6 databases for peer-reviewed articles published after 1940. We identified articles evaluating medication adherence among patients ,25 years old with SCD. Two authors reviewed each article to determine whether it should be included. Two authors extracted data, including medication studied, adherence measures used, rates of adherence, and barriers to adherence. RESULTS:Of 24 articles in the final review, 23 focused on 1 medication type: antibiotic prophylaxis (13 articles), iron chelation (5 articles), or hydroxyurea (5 articles). Adherence rates ranged from 16% to 89%; most reported moderate adherence. Medication factors contributed to adherence. For example, prophylactic antibiotic adherence was better with intramuscular than oral administration. Barriers included fear of side effects, incorrect dosing, and forgetting. Nonadherence was associated with more vaso-occlusive crises and hospitalizations. The limited data available on moderate adherence to iron chelation and hydroxyurea indicates some clinical benefit. CONCLUSIONS:Moderate adherence is typical among pediatric patients with SCD. Multicomponent interventions are needed to optimally deliver life-changing medications to these children and should include routine monitoring of adherence, support to prevent mistakes, and education to improve understanding of medication risks and benefits. Pediatrics

show abstract

Prevalence of daily medication adherence among children with sickle cell disease: A 1‐year retrospective cohort analysis

Cited by 43 publications

References 17 publications

Preventive Care Delivery to Young Children With Sickle Cell Disease

Preventive Care Delivery to Young Children With Sickle Cell Disease

Adherence to hydroxyurea medication by children with sickle cell disease (SCD) using an electronic device: a feasibility study

Medication Adherence Among Pediatric Patients With Sickle Cell Disease: A Systematic Review

Contact Info

Product

Resources

About