Prevalence of dementia and major dementia subtypes in the Chinese populations: A meta-analysis of dementia prevalence surveys, 1980–2010

Zhang, Yaodong; Xu, Yong; Nie, Hu; Lei, Ting; Wu, Yan; Zhang, Ling; Zhang, Minjie

doi:10.1016/j.jocn.2012.01.029

Cited by 94 publications

(75 citation statements)

References 15 publications

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“…A meta-analysis including 18 studies from China during 1990-2010 showed prevalence of Alzheimer's disease of 1.9% [16]. More than 25 million people in the world are currently affected by dementia, most suffering from Alzheimer's disease, with around 5 million new cases occurring every year [11].…”

Section: Prevalencementioning

confidence: 99%

Epidemiology of Alzheimer’s Disease

Xu¹,

Ferrari²,

Wang³

2013

Understanding Alzheimer's Disease

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Section: Prevalencementioning

confidence: 99%

Epidemiology of Alzheimer’s Disease

Xu¹,

Ferrari²,

Wang³

2013

Understanding Alzheimer's Disease

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“…1 AD has an even higher prevalence in western countries, with >5 million people affected in the USA, and this is expected to rise in future. 2 AD is a neurodegenerative disease characterized by the deposition of senile plaques in the brain, a pathogenesis that probably starts years before the symptoms of AD develop.…”

Section: Introductionmentioning

confidence: 99%

Curcumin reduces hippocampal neuron apoptosis and JNK-3 phosphorylation in rats with Aβ-induced Alzheimer's disease: protecting spatial learning and memory

Wang¹,

Li²,

Wang³

et al. 2017

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Amyloid-β peptide (Aβ) toxicity in Alzheimer's disease (AD) is associated with the c-Jun N-terminal kinase (JNK) signaling pathway. Curcumin may prevent Aβ fiber formation, slowing AD progression. A model of AD was established in 32 Sprague Dawley rats by injection of 10 μg Aβ 1-40 into the right hippocampus. Saline was used in sham control (n=16). Sixteen AD model rats received 300 mg/kg curcumin and another 16 received saline daily for 7 days. Spatial learning and memory were assessed using a Morris water maze. Hippocampus neuron apoptosis and hippocampal levels of JNK-3 and p-JNK-3 were assessed by terminal deoxynucleotidyl transferase dUTP nick end labeling, reverse transcription-polymerase chain reaction and Western blotting. Aβ 1-40 injection induced slower spatial learning, memory deficit, neuronal apoptosis and increased JNK-3 expression and phosphorylation (all P<0.05). Curcumin relieved spatial learning and memory deficits, hippocampus neuronal apoptosis, and reduced JNK-3 and p-JNK-3 levels (all P<0.05). In conclusion, curcumin may inhibit JNK-3 phosphorylation to protect against hippocampal neuron apoptosis after Aβ injection.

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“…Vascular dementia (VD), an age-related chronic disease, involves the progressive loss of memory and cognitive function, accounting for nearly 20 to 40% of dementia cases after Alzheimer's disease (AD) (Lee 2011;Zhang et al 2012a). It is reported that the prevalence of VD ranges from 0.4 to 1.6% among individuals aged 60 years and older (Lobo et al 2000;Tiwari et al 2013;Jia et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Global Gene Expression Profile of the Hippocampus in a Rat Model of Vascular Dementia

Feng

et al. 2015

Tohoku J. Exp. Med.

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Vascular dementia (VD) has been one of the most serious public health problems worldwide. It is well known that cerebral hypoperfusion is the key pathophysiological basis of VD, but it remains unclear how global genes in hippocampus respond to cerebral ischemia-reperfusion. In this study, we aimed to reveal the global gene expression profile in the hippocampus of VD using a rat model. VD was induced by repeated occlusion of common carotid arteries followed by reperfusion. The rats with VD were characterized by deficit of memory and cognitive function and by the histopathological changes in the hippocampus, such as a reduction in the number and the size of neurons accompanied by an increase in intercellular space. Microarray analysis of global genes displayed up-regulation of 7 probesets with genes with fold change more than 1.5 (P < 0.05) and down-regulation of 13 probesets with genes with fold change less than 0.667 (P < 0.05) in the hippocampus. Gene Ontology (GO) and pathway analysis showed that the up-regulated genes are mainly involved in oxygen binding and transport, autoimmune response and inflammation, and that the down-regulated genes are related to glucose metabolism, autoimmune response and inflammation, and other biological process, related to memory and cognitive function. Thus, the abnormally expressed genes are closely related to oxygen transport, glucose metabolism, and autoimmune response. The current findings display global gene expression profile of the hippocampus in a rat model of VD, providing new insights into the molecular pathogenesis of VD.

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Prevalence of dementia and major dementia subtypes in the Chinese populations: A meta-analysis of dementia prevalence surveys, 1980–2010

Cited by 94 publications

References 15 publications

Epidemiology of Alzheimer’s Disease

Epidemiology of Alzheimer’s Disease

Curcumin reduces hippocampal neuron apoptosis and JNK-3 phosphorylation in rats with Aβ-induced Alzheimer's disease: protecting spatial learning and memory

Global Gene Expression Profile of the Hippocampus in a Rat Model of Vascular Dementia

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Prevalence of dementia and major dementia subtypes in the Chinese populations: A meta-analysis of dementia prevalence surveys, 1980–2010

Cited by 94 publications

References 15 publications

Epidemiology of Alzheimer’s Disease

Epidemiology of Alzheimer’s Disease

Curcumin reduces hippocampal neuron apoptosis and JNK-3 phosphorylation in rats with A&beta;-induced Alzheimer&#39;s disease: protecting spatial learning and memory

Global Gene Expression Profile of the Hippocampus in a Rat Model of Vascular Dementia

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Curcumin reduces hippocampal neuron apoptosis and JNK-3 phosphorylation in rats with Aβ-induced Alzheimer's disease: protecting spatial learning and memory