Prevalence of dental alterations in patients under bisphosphonates therapy: a systematic review

Pauli, Monique Abreu; Bordignon, Natália Cristina Trentin; Martini, Geórgia Ribeiro; Minamisako, Mariana Comparotto; Gondak, Rogério

doi:10.1007/s10006-022-01084-9

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…According to Abreu Pauli, bisphosphonates therapy may cause some dental alterations. The most frequent alteration is pulp necrosis which comprises 92.3% of alteration 25 . Nonvital teeth are more prone to cracks and fractures.…”

Section: Discussionmentioning

confidence: 99%

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Effect of posterior implant restorations on adjacent teeth and tissues: A case–control study

Tagger-Green‬‎

Fridenberg

Segal

et al. 2023

Clin Implant Dent Rel Res

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Introduction: Dental implants are an artificial substitute for extracted or missing teeth in the oral cavity and are valuable for improving dental health and quality of life. While many studies on implants can be found, few studies examine their effects on adjacent teeth and tissues. The study aimed to examine complications of teeth adjacent to dental implants in the posterior region.Methods: In this retrospective case-control study, clinical data of patients treated

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Section: Discussionmentioning

confidence: 99%

“…The most frequent alteration is pulp necrosis which comprises 92.3% of alteration. 25 Nonvital teeth are more prone to cracks and fractures. It may be explained by the modulus of elasticity and the fracture toughness of teeth that changes might reduce dentin's moisture content with aging and with the loss of vital pulp tissue.…”

Section: Discussionmentioning

confidence: 99%

Effect of posterior implant restorations on adjacent teeth and tissues: A case–control study

Tagger-Green‬‎

Fridenberg

Segal

et al. 2023

Clin Implant Dent Rel Res

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Peri‐implant medication‐related osteonecrosis of the jaw mimicking endodontic disease in a cancer patient: A case report

Rocha,

Mota,

Lima

et al. 2024

Aust Endodontic J

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Medication‐related osteonecrosis of the jaw (MRONJ) is a progressive condition that can cause significant bone loss and its diagnosis can be challenging. A 68‐year‐old man with a diagnosis of hepatocellular carcinoma, undergoing treatment with atezolizumab, bevacizumab and zoledronic acid, complained of spontaneous pain in the right lower second premolar. Oral examination revealed no dental changes and implants in the right jaw. A patient history and thorough clinical and radiographic examinations mimic endodontic disease. The implant crowns were removed, bleeding on probing, and peri‐implant pockets were observed. The main hypothesis was MRONJ Stage 2, and the surgical treatment was performed. The pain ceased and signs of MRONJ were not observed within 3 months. MRONJ should be considered as a hypothesis in the case of odontalgia and a patient's history of antiresorptive and antiangiogenic therapies. Furthermore, monitoring patients with dental implants in the mandible through detailed clinical and imaging evaluation is required.

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Osteoporosis and Apical Periodontitis Prevalence: A Systematic Review

Pestana de Vasconcelos,

Martins,

Afonso

et al. 2024

Dentistry Journal

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Osteoporosis is a common systemic bone disorder in the elderly, characterized by low bone mineral density and deterioration of bone structure. Apical periodontitis is an inflammatory response to the microbial infection of root canals, typically characterized by apical bone destruction surrounding the tooth’s apex. This systematic review aimed to determine if osteoporosis affects the prevalence of apical periodontitis in adults. PRISMA guidelines have been followed. It included randomized clinical trials, cross-sectional, cohort, and case-control studies, and excluded non-relevant investigations and various secondary sources. A comprehensive search was performed in PubMed, Scopus, and Web of Science, until 13 March 2024. The Newcastle–Ottawa Scale was used to assess the quality of the three selected studies: two cross-sectional studies and one case-control study. One investigation only included post-menopausal women recruited at a dental university clinic, the other integrated data from the total hospital patients’ population, and the third selected patients referred to the university dental clinic from the university hospital. The findings varied: one study noted a marginal association between low bone mineral density and apical periodontitis, another found a significant association, and the third, with the lowest risk of bias, reported no link. The main limitations were the scarcity of eligible studies and their overall quality. The review was registered in the PROSPERO database (CRD42024523705), applied strict inclusion criteria and thorough searches by experienced and independent reviewers. There is no strong evidence that adult individuals with osteoporosis have a higher probability of developing apical periodontitis. However, clinicians should remain cautious of osteoporosis’s potential impact on apical periodontitis development.

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Prevalence of dental alterations in patients under bisphosphonates therapy: a systematic review

Cited by 3 publications

References 46 publications

Effect of posterior implant restorations on adjacent teeth and tissues: A case–control study

Effect of posterior implant restorations on adjacent teeth and tissues: A case–control study

Peri‐implant medication‐related osteonecrosis of the jaw mimicking endodontic disease in a cancer patient: A case report

Osteoporosis and Apical Periodontitis Prevalence: A Systematic Review

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