Gelatin-based photopolymerizable methacrylate hydrogel (GelMA) is a promising biomaterial for in situ drug delivery, while aqueous extract of Punica granatum (AEPG) peel fruit rich in gallic acid and ellagic acid is used to improve wound healing. The aim of this study was to develop and analyze the healing properties of GelMA containing AEPG, gallic acid, or ellagic acid in a rodent model. GelMA hydrogels containing 5% AEPG (GelMA-GPG), 1.6% gallic acid (GelMA-GGA), or 2.1% ellagic acid (GelMA-GEA) were produced and their mechanical properties, enzymatic degradation, and thermogravimetric profile determined. Wound closure rates, healing histological grading, and immunohistochemical counts of myofibroblasts were assessed over time. The swelling of hydrogels varied between 50 and 90%, and GelMA exhibited a higher swelling than the other groups. The GPG samples showed higher compression and Young’s moduli than GelMA, GGA, and GAE. All samples degraded around 95% in 48 h. GPG and GGA significantly accelerated wound closure, improved collagenization, increased histological grading, and hastened myofibroblast differentiation in comparison to the control, GelMA, and GEA. GelMA containing AEPG (GPG) improved wound healing, and although gallic acid is the major responsible for such biological activity, a potential synergic effect played by other polyphenols present in the extract is evident. Graphical Abstract

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Results: Out of the 158 cases, the final histopathological analysis of the hysterectomy specimen revealed that 105 cases were truly low-risk cases (G1/G2 endometrioid tumors not affecting the cervix and myometrial infiltration < 50% G1/G2). 9 cases were proved to be G3 with infiltration <50% and no cervical involvement. While 44 cases were found to be at high risk because of myometrial invasion > 50% and / or cervical involvement (6 cases were G3, 4 of them were carcinosarcomas). Regardless definitive histologic gradedata that ultrasound cannot provide -, ultrasound correctly identified 81.2% (36/44) of cases of myometrial infiltration > 50% and / or cervical involvement and 85% (96/114) of cases with myometrial infiltration < 50% and / or without cervical involvement. Conclusions: Preoperative ultrasound provides a good diagnostic performance to identify high-risk cases in well or moderately differentiated endometrioid endometrial carcinomas. OP09.06The association of changes in cervical cancerechogenicity and vascularization with treatment effect of neoadjuvant chemotherapy

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