Prevalence of dental caries in children and adolescents with type 1 diabetes: a systematic review and meta-analysis

Wang, Yan; Lin, Xing; Yu, Hui; Zhao, Lijuan

doi:10.1186/s12903-019-0903-5

Cited by 39 publications

(34 citation statements)

References 36 publications

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“…The present meta-analysis revealed that 45.7% (95% CI = 38.0–53.4) of people had dental caries in East Africa, which is similar to a meta-analysis done in Ethiopia (40.98%, 95% CI = 31.62–50.34) ( 17 ) and a study done in China (41.15%) ( 70 ). However, the estimate of dental caries in the present study was lower than those in studies done in Gulf countries (64.7%) ( 71 ), Brazil (72.9%) ( 72 ), Kosovo (72.80%) ( 73 ), and China (67%, 95% CI = 56.0–77.0) ( 74 ). This difference might be due to differences in socioeconomic, dietary habits, oral hygiene practices, and knowledge and attitude of oral health prevention programs in these countries ( 75 ).…”

Section: Discussioncontrasting

confidence: 90%

Prevalence of Dental Caries and Associated Factors in East Africa, 2000–2020: Systematic Review and Meta-Analysis

Teshome

Muche

Girma

2021

Front. Public Health

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Background: Dental caries affects mastication, growth and development, and school attendance and has a long-term psychological effect on affected individuals. In developing countries, the prevalence of dental caries is increasing due to the growing consumption of sugary foods, poor tooth brushing habits, and a low level of awareness about dental caries. Even if there was a high prevalence of dental caries in sub-Saharan Africa, there is a paucity of data on the prevalence of dental caries in East Africa. Hence, this study aimed to determine the prevalence of dental caries and associated factors in East Africa.Methods: A systematic search of articles was conducted in MEDLINE, Scopus, and Google Scholar using all the synonyms of dental caries in published literature (until December 2020) in East Africa. Important data were extracted using a standardized data extraction form prepared in Excel. Stata software (version 14.0) was used to calculate the pooled prevalence of dental caries. Besides, subgroup analysis was done based on country and dentition type. Moreover, associated factors of dental caries were assessed and the overall effect was presented in the form of odds ratios. The quality of the included studies was evaluated using the Joanna Briggs Institute reviewers' manual.Results: The overall pooled prevalence of dental caries was found to be 45.7% (95% CI = 38.0–53.4). The pooled prevalence was high in Eritrea (65.2%, 95% CI = 49.2–81.1), followed by Sudan (57.8%, 95% CI = 36.0–79.7), and a low prevalence was found in Tanzania (30.7%, 95% CI = 21.5–39.9). Moreover, the subgroup analysis revealed a prevalence of 50% (95% CI = 38.4–62.1) in permanent dentition and 41.3% (95% CI = 33.5–49.2) in mixed dentition. The overall mean decayed, missed, and filled permanent (DMFT) and primary (dmft) teeth were 1.941 (95% CI = 1.561–2.322) and 2.237 (95% CI = 1.293–3.181), respectively. High DMFT scores were reported in Sudan (3.146, 95% CI = 1.050–5.242) and Uganda (2.876, 95% CI = 2.186–3.565). Being female (OR = 1.34, 95% CI = 1.24–1.46) and having poor tooth brushing habit (OR = 1.967, 95% CI = 1.67–2.33) were independent risk factors of dental caries.Conclusion: The overall prevalence of dental caries was comparatively high. Being female and poor oral health practice were independent risk factors of dental caries. The Ministry of Health of the member countries, along with dental associations of each country, ought to offer due attention to strengthen the oral health program in schools and primary health care centers and the implementation of school water fluoridation.

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Section: Discussioncontrasting

confidence: 90%

Prevalence of Dental Caries and Associated Factors in East Africa, 2000–2020: Systematic Review and Meta-Analysis

Teshome

Muche

Girma

2021

Front. Public Health

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“…There are cases when pulmonary embolism manifests itself with T waves in leads V2-V3 (similar to type A Wellens' syndrome) with subsequent T-wave inversion (similar to type B of this syndrome) [15]. Sometimes, such changes can be observed in young people who have been diagnosed with pulmonary embolism due to the use of neuroleptics (which increase the risk of thromboembolic complications) [16]. ECG changes typical for Wellens' syndrome have also been described in the case of acute pancreatitis; coronary angiography revealed an abnormal origin of the right coronary artery from the left sinus of Valsalva; no signs of atherosclerotic lesions were detected [17].…”

Section: Discussionmentioning

confidence: 99%

Wellens’ Syndrome: Focus on Diagnosis and Choice of Myocardial Revascularization Strategy

et al. 2020

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Abstract. Wellens’ syndrome is an extremely relevant issue in modern cardiology. Wellens’ syndrome is quite often untimely diagnosed, and the patient’s management is the same as in case of unstable angina. Since without myocardial revascularization, widespread myocardial infarction develops within the following days or weeks, myocardial revascularization is needed as soon as possible. Characteristic changes on the electrocardiogram in case of Wellens’ syndrome include biphasic (type A) or inverted (type B) T waves in leads V2-V3, which sometimes are seen in other precordial leads. There must be a history of recent angina in addition to these electrocardiogram changes. Troponin is usually negative; however, it can be slightly elevated. Sometimes, patients with classic electrocardiogram changes and clinical picture typical for Wellens’ syndrome do not show hemodynamically significant stenosis of the left anterior descending artery typical for this syndrome. In such cases, “pseudo-Wellens’ syndrome” is observed. Three cases of angiographically confirmed Wellens’ syndrome and one case of pseudo-Wellens’ syndrome are presented in this paper. All the patients with Wellens’ syndrome had significant lesions of the left anterior descending artery. One patient had a triple-vessel lesion, and the other two had a single-vessel lesion. Troponin I was within normal limits in one patient, and slightly elevated and in the other two. These patients underwent successful myocardial revascularization (percutaneous coronary intervention); pharmacological therapy was prescribed.

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“…Moreover, youngsters with T1D are shown to have a lower oral hygiene level and are potentially at a higher risk of future oral disease, mainly when their metabolic disorder is uncontrolled [22]. This is confirmed by a recent meta-analysis, showing a high global prevalence of dental caries among children and adolescents with T1D [23]. Further research on the risk of dental caries is necessary to maximize preventive measures and ensure optimal oral health for such vulnerable patients [18,19,24].…”

Section: Introductionmentioning

confidence: 89%

“…Modern proteomic techniques, including mass spectrometry, have shown that saliva analysis can detect the presence or absence of multiple biomarkers, which can act as potential indicators for the early detection, progression monitoring, or response to treatment of many oral and systemic diseases. Furthermore, saliva sample collection is a non-invasive, painless, simple, quick, easy, safe, and inexpensive option compared to collecting other body constituents [23]. Particularly in specific groups, such as children, saliva can be considered an ideal diagnostic fluid since its collection causes minimal patients' discomfort and guarantees cooperation [25].…”

Section: Introductionmentioning

confidence: 99%

Downregulation of Salivary Proteins, Protective against Dental Caries, in Type 1 Diabetes

et al. 2021

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Saliva, an essential oral secretion involved in protecting the oral cavity’s hard and soft tissues, is readily available and straightforward to collect. Recent studies have analyzed the salivary proteome in children and adolescents with extensive carious lesions to identify diagnostic and prognostic biomarkers. The current study aimed to investigate saliva’s diagnostic ability through proteomics to detect the potential differential expression of proteins specific for the occurrence of carious lesions. For this study, we performed bioinformatics and functional analysis of proteomic datasets, previously examined by our group, from samples of adolescents with regulated and unregulated type 1 diabetes, as they compare with healthy controls. Among the differentially expressed proteins relevant to caries pathology, alpha-amylase 2B, beta-defensin 4A, BPI fold containing family B member 2, protein S100-A7, mucin 5B, statherin, salivary proline-rich protein 2, and interleukin 36 gamma were significantly downregulated in poorly-controlled patients compared to healthy subjects. In addition, significant biological pathways (defense response to the bacterium, beta-defensin activity, proline-rich protein activity, oxygen binding, calcium binding, and glycosylation) were deregulated in this comparison, highlighting specific molecular characteristics in the cariogenic process. This analysis contributes to a better understanding of the mechanisms involved in caries vulnerability in adolescents with unregulated diabetes.

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Prevalence of dental caries in children and adolescents with type 1 diabetes: a systematic review and meta-analysis

Cited by 39 publications

References 36 publications

Prevalence of Dental Caries and Associated Factors in East Africa, 2000–2020: Systematic Review and Meta-Analysis

Prevalence of Dental Caries and Associated Factors in East Africa, 2000–2020: Systematic Review and Meta-Analysis

Wellens’ Syndrome: Focus on Diagnosis and Choice of Myocardial Revascularization Strategy

Downregulation of Salivary Proteins, Protective against Dental Caries, in Type 1 Diabetes

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