Prevalence of Depressive Symptoms Among Patients With Chronic Cough

Dicpinigaitis, Peter V.; Tso, Raymond; Banauch, Gisela I.

doi:10.1378/chest.130.6.1839

Cited by 132 publications

(114 citation statements)

References 31 publications

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“…Furthermore, depression scores dramatically improved in patients whose cough was successfully treated. 26 Psychological problems may increase the cough frequency, but it would seem more plausible that the patients with the highest cough rates have the greatest psychological consequences. Data on the relationship between cough reflex sensitivity and cough frequency are limited.…”

Section: Discussionmentioning

confidence: 99%

Chronic cough: how do cough reflex sensitivity and subjective assessments correlate with objective cough counts during ambulatory monitoring?

Decalmer

Webster

Kelsall

et al. 2007

Thorax

123

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Background: Cough reflex sensitivity, subjective estimates of cough frequency and cough-related quality of life have been used to assess cough and monitor treatment responses. The relationships between these measures and objective cough monitoring remain unclear and the usefulness of subjective assessments remains questionable. Subjects: 62 patients with chronic cough (39 women) were studied. Mean age of patients was 54.9 (SD 12.2) years, with a median duration of cough of 5.5 (range 1-30) years. Methods: Cough reflex sensitivity testing (C5; citric acid) was performed in all patients before fully ambulatory day-time and night-time cough recordings. Patients scored the frequency and severity of their cough (Visual Analogue Scales (VAS) and 0-5 score) for each recording period and completed a cough-related quality-oflife questionnaire, Leicester Cough Questionnaire (LCQ). Ambulatory cough recordings were manually counted and reported in terms of cough seconds per hour (cs/h). Cough rates were log 10 transformed for analysis. Results: The median time spent coughing was 11.36 (range 1.06-46) cs/h with median day rates of 15.59 (range 2-74.8) cs/h and median night rates of 2.94 (range 0-26.67) cs/h. An inverse relationship was seen between day cough rates and log 10 C5 (r = 20.452, p(0.001). Subjective cough scores and visual analogue scales were only moderately associated with objective time spent coughing, with night-time being scores more strongly associated than day-time scores. The strongest correlation with objective cough frequency was cough-related quality of life (LCQ), (r = 20.622, p(0.001), mediated through the psychological domain. Conclusions: Subjective measures of cough and cough reflex sensitivity are only moderately related to objective time spent coughing, and hence cannot be used as surrogate markers for objective cough-frequency measurements. Cough-related quality of life (LCQ) is most strongly related to objectively counted cough, and may be a useful adjunct to objective measures in the assessment of cough.

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Section: Discussionmentioning

confidence: 99%

Chronic cough: how do cough reflex sensitivity and subjective assessments correlate with objective cough counts during ambulatory monitoring?

Decalmer

Webster

Kelsall

et al. 2007

Thorax

123

View full text Add to dashboard Cite

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“…In patients with chronic cough, quality of life is impaired, to a greater extent in female patients compared with males [109] and not related to age, duration or aetiology [92,110]. The psychological aspects of health status are particularly affected in patients with chronic cough, and there is a high prevalence of depressive symptoms [109][110][111]. There is good evidence that health status improves significantly after specific therapy for the cough [8,9].…”

Section: Health Status In Chronic Coughmentioning

confidence: 99%

ERS guidelines on the assessment of cough

Morice¹,

Fontana²,

Belvisi³

et al. 2007

Eur Respir J

612

619

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“…However the majority of patients presenting with chronic cough do not easily fit into these diagnostic labels, and indeed there is frequently no obvious indicators as to the underlying diagnosis. However, patients suffer a marked decrement in quality of life comparable to patients with disseminated lung cancer or end-stage COPD [3,4]. This adverse impact on quality of life is under recognised by clinicians, according to the recent European Respiratory Society (ERS) survey [5].…”

Section: Introductionmentioning

confidence: 99%

A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response

et al. 2014

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Reports from individual centres suggest a preponderance of females with chronic cough. Females also have heightened cough reflex sensitivity. Here we have reviewed the age and sex of unselected referrals to 11 cough clinics. To investigate the cause of any observed sex dimorphism, functional magnetic resonance imaging of putative cough centres was analysed in normal volunteers.The demographic profile of consecutive patients presenting with chronic cough was evaluated. Cough challenge with capsaicin was undertaken in normal volunteers to construct a concentration-response curve. Subsequent functional magnetic resonance imaging during repeated inhalation of sub-tussive concentrations of capsaicin observed areas of activation within the brain and differences in the sexes identified.Of the 10 032 patients presenting with chronic cough, two-thirds (6591) were female (mean age 55 years). The patient profile was largely uniform across centres. The most common age for presentation was 60-69 years. The maximum tolerable dose of inhaled capsaicin was lower in females; however, a significantly greater activation of the somatosensory cortex was observed.Patients presenting with chronic cough from diverse racial and geographic backgrounds have a strikingly homogeneous demographic profile, suggesting a distinct clinical entity. The preponderance of females may be explained by sex-related differences in the central processing of cough sensation. @ERSpublications Chronic cough in specialist clinics have homogenous demographic profiles, suggesting single clinical entity

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Prevalence of Depressive Symptoms Among Patients With Chronic Cough

Cited by 132 publications

References 31 publications

Chronic cough: how do cough reflex sensitivity and subjective assessments correlate with objective cough counts during ambulatory monitoring?

Chronic cough: how do cough reflex sensitivity and subjective assessments correlate with objective cough counts during ambulatory monitoring?

ERS guidelines on the assessment of cough

A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response

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