2018
DOI: 10.1089/aid.2017.0257
|View full text |Cite
|
Sign up to set email alerts
|

Prevalence of Drug Resistance Mutations in Protease, Reverse Transcriptase, and Integrase Genes of North Central Mexico HIV Isolates

Abstract: This study set out to determine the frequency of antiretroviral drug resistance mutations in treatment-naive subjects of the north central Mexican state of San Luis Potosí. Mexican studies of antiretroviral drug resistance mutations have focused mainly on large metropolitan areas and border towns subjected to intense international migrations. This study set forth to describe the frequency of these mutations in a Mexican region less subjected to such migratory influences and more representative of smaller Mexic… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

1
3
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 7 publications
(4 citation statements)
references
References 45 publications
1
3
0
Order By: Relevance
“…Similar observations have been reported in previous studies [23][24][25]. Subtyping of currently prevailing HIV-1 isolates is considered crucial for understanding the genetic evolution of this virus around the globe [26], and, for this particular purpose, the pol gene is considered an important marker for accurate delineation of HIV-1 subtypes [15][16][17][27][28][29]. The amplified region of the pol gene comprised the protease gene (nt 1 to 297) and a part of the reverse transcriptase (RT) gene (nt 1 to 753).…”
supporting
confidence: 81%
“…Similar observations have been reported in previous studies [23][24][25]. Subtyping of currently prevailing HIV-1 isolates is considered crucial for understanding the genetic evolution of this virus around the globe [26], and, for this particular purpose, the pol gene is considered an important marker for accurate delineation of HIV-1 subtypes [15][16][17][27][28][29]. The amplified region of the pol gene comprised the protease gene (nt 1 to 297) and a part of the reverse transcriptase (RT) gene (nt 1 to 753).…”
supporting
confidence: 81%
“…As for PI/r resistance, rates after first-line failure were, not surprisingly, low (5%), supported by the absence of PI/r drug pressure in first-line treated patients. The PI/r resistance in first-line patients would thus be driven mostly by the presence of transmitted drug resistances, which is low in the PI/r class, as described in Mexico by Gerardo et al in 2018 who found the prevalence of PI/r transmitted drug resistance to be 4.9% [ 32 ]. After second-line failure, rates of NRTI and NNRTI resistance all remained high (92.9% and 84.1% respectively).…”
Section: Discussionmentioning
confidence: 99%
“…To best of our knowledge, this is the first ever study to explore different HIV-1 subtypes and CRFs circulating in IDUs in Lahore. HIV-1 Subtyping is crucial to understand genetic evolution of circulating HIV-1 isolates in the world (Pond et al, 2009) and, pol gene of HIV-1 is an important marker to accurately delineate HIV-1 genetic diversity (Cantão et al, 2018;Gonzales et al, 2001;Hernandez-Sanchez et al, 2018;Song et al, 2018). The identification of different HIV-1 subtypes and recombinant form within specific population within same region highlights its propensity to be a highly mutable virus, therefore, time to time molecular epidemiological studies are required to conduct at a much higher resolution in future.…”
Section: Discussionmentioning
confidence: 99%