Prevalence of endoscopically negative and positive gastroesophageal reflux disease in the Japanese

Mishima, Ikuyo; Adachi, Kyoichi; Arima, Noriyuki; Amano, Kazutoshi; Takashima, Toshiharu; Moritani, Makoto; Furuta, K.; Kinoshita, Yoshikazu

doi:10.1080/00365520510023260

Cited by 146 publications

(167 citation statements)

References 27 publications

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“…GERD is influenced by multiple factors, including gastric acid secretion, hiatal hernia, the lower esophageal sphincter function, esophageal motility, esophageal perception and others (1,(3)(4)(5)28). The prevalence of GERD has increased among Asian populations in recent decades, and the increment in the rate of GERD in Asians is thought to be caused by several factors.…”

Section: Discussionmentioning

confidence: 99%

“…GERD has been becoming more prevalent in Asian populations in recent decades, and although the disease is considered to be a common disorder in both Western and Asian populations, its increasing prevalence in Asia may be due to multiple factors, such as the Westernization of eating habits, decrease in the rate of Helicobacter pylori infection, increased gastric acid secretion and a larger elderly population, as well as other factors (2)(3)(4)(5)(6)(7)(8)(9). High intra-abdominal pressure caused by abdominal fat accumulation has been demonstrated to increase the gastroesophageal pressure gradient and incidence of gastroesophageal reflux, while obesity and a high body mass index (BMI) have repeatedly been reported to be correlated with a high prevalence of reflux esophagitis and symptoms of GERD (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

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Gender Differences in the Time-Course Changes of Reflux Esophagitis in Japanese Patients

et al. 2015

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Objective Obesity is related to an increased prevalence of reflux esophagitis and gastroesophageal reflux disease symptoms. This study was performed to clarify the influence of gender on time-course changes in the rate of a high BMI and incidence of reflux esophagitis in Japanese subjects. Results A multiple logistic regression analysis showed that a high BMI, milder degree of gastric mucosal atrophy and larger size of diaphragmatic hiatus were significant predictive factors for the presence of reflux esophagitis in both men and women. The number of male subjects with reflux esophagitis and a high BMI increased during the 10-year examination period. In contrast, the number of individuals with reflux esophagitis and a high BMI was not increased among women. For both men and women, the proportions of patients with a large diaphragmatic hiatus and mild gastric mucosal atrophy increased during the 10-year period. Conclusion The prevalence of reflux esophagitis in the female subjects remained constant over 10 years, different from that observed in the men. A lack of change in BMI may be an important factor accounting for the constant prevalence of reflux esophagitis in women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gender Differences in the Time-Course Changes of Reflux Esophagitis in Japanese Patients

et al. 2015

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“…7 Interestingly, there is a male-predominant sex difference through the spectrum of reflux esophagitis, BE, and EAC. [7][8][9] In addition, the male to female ratios become higher with more progression towards EAC. 7 Meanwhile, reflux symptoms and NERD generally affect more women than men.…”

Section: Introductionmentioning

confidence: 99%

“…7 Meanwhile, reflux symptoms and NERD generally affect more women than men. 7,9 Epidemiological data have suggested that the esophageal mucosal epithelium is more fragile to refluxed gastroduodenal contents in men compared to that of women, 7,10 although women are more susceptible to GERD symptoms than men. Sex means a human's biological status based on their reproductive systems and functions assigned by chromosomal type.…”

Section: Introductionmentioning

confidence: 99%

Sex and Gender Differences in Gastroesophageal Reflux Disease

Kim

2016

J Neurogastroenterol Motil

125

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It is important to understand sex and gender-related differences in gastroesophageal reflux disease (GERD) because gender-related biologic factors might lead to better prevention and therapy. Non-erosive reflux disease (NERD) affects more women than men. GERD symptoms are more frequent in patients with NERD than in those with reflux esophagitis. However, men suffer pathologic diseases such as reflux esophagitis, Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC) more frequently than women. The prevalence of reflux esophagitis is significantly increased with age in women, especially after their 50s. The mean age of EAC incidence in women is higher than in men, suggesting a role of estrogen in delaying the onset of BE and EAC. In a chronic rat reflux esophagitis model, nitric oxide was found to be an aggravating factor of esophageal injury in a male-predominant way. In addition, the expression of esophageal occludin, a tight junction protein that plays an important role in the esophageal defense mechanism, was up-regulated in women. This explains the male predominance of reflux esophagitis and delayed incidence of BE or EAC in women. Moreover, the symptoms such as heartburn, regurgitation, and extra-esophageal symptoms have been more frequently reported by women than by men, suggesting that sex and gender play a role in symptom perception. Differential sensitivity with augmented symptoms in women might have diagnostic and therapeutic influence. Furthermore, recent studies have suggested that hormone replacement therapy has a protective effect against esophageal cancer. However, an anti-inflammatory role of estrogen remains compelling, which means further study is necessary in this area.

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“…14 Relying upon endoscopic examination and the presence of GERD symptoms, a Japanese study found a 17.9 % GERD prevalence in the adult population, among which 7.1 % were diagnosed with esophagitis and 10.8% not. 26 Regarding the consumption of beverages causing erosion, coffee (58.2%), carbonized drinks (57%), tea (24.1%) and, to a lesser extent, fruit juice (13.9%), soft drinks (13.9%) and energy drinks (3.8%) were relevant in the present study. The tooth surface examination has shown that in case of extrinsic and intrinsic acidic effects, mainly frontal and molar teeth featured enamel alterations, on the occlusal surface, as well as on the buccal tooth neck areas, mainly on the mandible.…”

Section: Discussionmentioning

confidence: 96%

Preliminary Assessment of Risk Factors for Tooth Wear

Birta

Kerekes-Máthé

Martha

et al. 2017

Journal of Interdisciplinary Medicine

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Background: Epidemiological studies have reported an increasing prevalence of tooth wear, and general dental practitioners see a greater number of patients seeking treatment with worn dentition. Improper oral hygiene, unhealthy habits, occupational hazards, and potentially erosive processed foods seem to play a major role in the non-carious loss of dental hard tissue. The aim of this study is to assess the factors and cofactors that may play a major role in the genesis of dental attrition, dental abrasion, and, especially, dental erosion. Material and methods: Seventy-nine consecutive patients, aged between 17 and 78 years, have enrolled in our study, completing a questionnaire regarding chronic illnesses, eating habits, and dental hygiene, followed by a dental clinical examination. Results: The male-female ratio was 1.4:1, with a mean age of 35.6 years. Forty-four (55.7%) patients presented objective signs of tooth wear. Regarding oral hygiene habits, the use of a hard toothbrush is linked to increased tooth wear, while brushing in a circular motion seems to be the least abrasive. We found a considerable prevalence of bruxism (19%), which led to severe generalized attrition in almost half of such patients. The most popular drinks with erosive potential were coffee (58.2%), soft drinks (57%), and tea (24.1%), and extrinsic erosion was more frequent in patients younger than 30 years. Understandably, physiological tooth wear was more common in older patients. The questionnaire revealed that over 60% of patients have inaccurate knowledge of tooth wear. Conclusions: Tooth wear is partially a progressive physiological process. Unfortunately, we see it increasing in younger patients due to pathological influencing factors. These include improper tooth brushing technique and materials, bruxism, dental prosthesis, dietary habits. Primordial and primary prevention is the key to reducing morbidity, health education being an essential part of it.

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Prevalence of endoscopically negative and positive gastroesophageal reflux disease in the Japanese

Cited by 146 publications

References 27 publications

Gender Differences in the Time-Course Changes of Reflux Esophagitis in Japanese Patients

Gender Differences in the Time-Course Changes of Reflux Esophagitis in Japanese Patients

Sex and Gender Differences in Gastroesophageal Reflux Disease

Preliminary Assessment of Risk Factors for Tooth Wear

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