Prevalence of erectile dysfunction in Korean men with Type 2 diabetes mellitus

Cho, N. H.; Ahn, Chul Woo; Park, J. Y.; Ahn, Tai Young; Lee, H. W.; Park, T. S.; Kim, I. J.; Pomerantz, Kenneth B.; Park, C.; Kimm, Kuchan; Choi, Dong Seop

doi:10.1111/j.1464-5491.2005.01789.x

Cited by 97 publications

(98 citation statements)

References 33 publications

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“…The prevalence of ED among diabetic men varies from 35% to 90% [1][2][3]. ED is three times more common in diabetic than in non-diabetic men, and may occur 10-15 years earlier in diabetic men.…”

Section: Introductionmentioning

confidence: 99%

Reduced expression of SK3 and IK1 channel proteins in the cavernous tissue of diabetic rats

Jun¹,

Jia²,

Xu³

et al. 2010

Asian J Androl

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The small (SK3) and intermediate (IK1) conductance calcium-activated potassium channels could have key roles in the endothelium-dependent hyperpolarization factor pathway, which is believed to contribute to normal penile erection function. We aimed to investigate the expression of SK3 and IK1 in diabetic rodents. The experimental diabetes model was induced in 8-week-old male Sprague-Dawley rats (250-300 g) by a single administration of streptozotocin. Both the diabetes mellitus group (DM group, n = 20) and the control group (NDM group, n = 10) were injected with a low dose of apomorphine to allow for the measurement and comparison of the corresponding penile erections. The mRNA and protein expression levels of SK3 and IK1 were measured by reverse transcription polymerase chain reaction and western blot, respectively. Erectile function was significantly decreased in the DM group compared with control group (P < 0.05). The mRNA and protein expression levels of SK3 and IK1 were reduced in the cavernous tissue of diabetic rats compared with the control group (P < 0.05). Diabetes inhibits mRNA and protein expression of both SK3 and IK1 in the cavernous tissue of diabetic rats. This could play a key role in the development of erectile dysfunction in diabetic rats.

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Section: Introductionmentioning

confidence: 99%

Reduced expression of SK3 and IK1 channel proteins in the cavernous tissue of diabetic rats

Jun¹,

Jia²,

Xu³

et al. 2010

Asian J Androl

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show abstract

“…It has been reported that about 35--90% of diabetic male rats suffer from ED. 2,3 The pathogenesis of DM-related ED may be involved in many aspects; however, it was well known that vascular causative factors contribute significantly. 4 Corpus cavernosum smooth muscle (CCSM), the structural basis of cavernous space relaxing and penile erection, has a key role in the change of hemodynamics during penile erection.…”

Section: Introductionmentioning

confidence: 99%

Characterization of corpus cavernosum smooth muscle cell phenotype in diabetic rats with erectile dysfunction

et al. 2012

Int J Impot Res

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Phenotypic modulation from a contractile to a proliferative state within vascular smooth muscle cells has a critical role in the pathogenesis of a variety of cardiovascular diseases. To investigate the characterization of corpus cavernosum smooth muscle cell phenotype in diabetic rats with erectile dysfunction, a group of Sprague--Dawley rats (n ¼ 30) were induced by intraperitoneal injection of streptozotocin (60 mg kg À1 ) and screened by subcutaneous injection of apomorphine (100 mg kg À1 ) for the measurement and comparison of the penile erections, and then three different groups were defined. Primary corpus cavernosum smooth muscle cells were cultured and passaged. The cavernous tissue segments were subjected to quantitative real-time polymerase chain reaction to determine the expressions of smooth muscle a-actin (SMA), SM myosin heavy chain (SMMHC), smoothelin, calponin and myocardin. Cell contractility in vitro and western blot analysis of SMA and SMMHC in the cavernous tissues and cells were determined. Compared with the control group (n ¼ 8) and the diabetes mellitus group (n ¼ 5), the expressions of SMA, calponin, SMMHC, smoothelin and myocardin mRNA were decreased in the cavernous tissues in rats of the diabetic erectile dysfunction group (n ¼ 15; P ¼ 0.001 and 0.02, P ¼ 0.014 and 0.012, both Po0.001, P ¼ 0.005 and o0.001, P ¼ 0.003 and 0.035, respectively). The levels of SMA and SMMHC proteins showed a significant decrease in cavernous tissues and cultured cells in rats of the diabetic erectile dysfunction group. Cells of the diabetic erectile dysfunction group exhibited significantly less contractility compared with those of other groups (Po0.001). Corpus cavernosum SM cell possesses the ability to modulate the phenotype under hyperglycemic conditions, which could have a key role in the pathogenesis of diabetic erectile dysfunction. Keywords: diabetes mellitus; erectile dysfunction; smooth muscle INTRODUCTION Erectile dysfunction (ED), a distressing complication of diabetes mellitus (DM), 1 is three times more common in diabetic male rats than in non-diabetic male rats. It has been reported that about 35--90% of diabetic male rats suffer from ED. 2,3 The pathogenesis of DM-related ED may be involved in many aspects; however, it was well known that vascular causative factors contribute significantly. 4 Corpus cavernosum smooth muscle (CCSM), the structural basis of cavernous space relaxing and penile erection, has a key role in the change of hemodynamics during penile erection. CCSM cell relaxation mediated by parasympathetic neurotransmission, nitric oxide, electrophysiological events and possibly other regulatory factors is necessary for normal penile erection. 5 It has been observed that the CCSM cell mass was lost in diabetic rats with ED, and the remaining SM cells were unable to achieve sufficient relaxation to attain the high intracorporeal pressures that are necessary for the passive occlusion of the veins that egress the corporal bodies as they traverse underneath and through the tunica albu...

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“…Erectile dysfunction (ED) is sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual activity over the course of three months (2), and is one of the chronic complications in males with type 2 diabetes. Numerous studies have reported that the incidence of ED in diabetic individuals varies between 30 and 80%, which is six times higher compared with normal individuals, and augments with an increase in age and duration of diabetes (3,4). The pathogenesis of diabetic ED is complex.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance and expression of microRNA in diabetic patients with erectile dysfunction

Jiang¹,

Luo²,

Zhao³

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the expression of microRNA (miR)-93, miR-320 and miR-16 and to assess their diagnostic value in diabetic patients with erectile dysfunction (ED). A total of 120 individuals were divided into three groups, which included the diabetics with ED group (ED group), the diabetics without ED group (NED group) and the healthy volunteers group (control group). Each group included 40 individuals. Serum samples were collected and reverse transcription quantitative polymerase chain reaction detection of the three types of miRNA was performed and the sensitivity of ED was analyzed by receiver operating characteristic curves. A negative correlation was identified between the incidence of ED in patients with diabetes and serum total testosterone levels (r=0.302, P<0.05); however, a positive correlation was observed between the incidence of ED in diabetics and the HbA1c level (r=0.231, P<0.05). Additionally, the relative expression levels of the three types of miRNA were higher in the ED group when compared with the NED and control groups (P<0.05). When compared with the control group, the area under the curve (AUC) values for miR-93, miR-320 and miR-16 were 0.793, 0.818 and 0.810, respectively, in the ED group and 0.576, 0.532 and 0.542 in the NED group, respectively. Furthermore, when compared with the NED group, the AUC value for miR-93, miR-320 and miR-16 was 0.707, 0.810 and 0.833, respectively, in the ED group. Therefore, the expression levels of miR-93, miR-320 and miR-16 may be useful for the early diagnosis of ED in patients with diabetes.

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Prevalence of erectile dysfunction in Korean men with Type 2 diabetes mellitus

Cited by 97 publications

References 33 publications

Reduced expression of SK3 and IK1 channel proteins in the cavernous tissue of diabetic rats

Reduced expression of SK3 and IK1 channel proteins in the cavernous tissue of diabetic rats

Characterization of corpus cavernosum smooth muscle cell phenotype in diabetic rats with erectile dysfunction

Clinical significance and expression of microRNA in diabetic patients with erectile dysfunction

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