Prevalence of extended-spectrum β-lactamase positive bacteria in radiologically positive urinary tract infection

Abstract

The increase in antibiotic resistance among uropathogens is a global problem. The present study was an effort to assess the current antibiotic resistance pattern and plasmid profiles of some multi drug resistant bacteria isolated from urinary tract infection (UTI). Among 44 clinical samples of radiologically positive UTI, 44 microorganisms belonging to 9 genus were isolated. Of the patients, 24 were female and 20 were male. Highest incidence was found in age group of 30–45 years. Total bacterial count of the urine samples were high in most the patients. E. coli and coagulase-negative Staphylococcus spp. were most prevalent. Most of the isolates showed higher antibiotic resistance against the antibiotics used. 6 of the 44 isolate was resistant to 10 different types of antibiotics. Of the isolated uropathogens, 40.9% were ESBL positive. 7 of the isolates had no plasmid and 9 isolate had 140 MDa plasmid whereas other isolates pose smaller plasmids of different sizes. Assessment of transfer of antibiotic resistance between different genuses revealed transfer of resistance within genus. Radiological imaging showed strong correlation with microbiological findings of the patients.

Prevalence and Antibiogram of Bacterial Uropathogens of Urinary Tract Infections from a Tertiary Care Hospital of Bangladesh

“…The highest significant growth (33%) was observed in the age groups of 21-40 years followed by 40 years or above (24.62%) and 0-20 years (23.53%) age groups. According to a study in 2014 [23] UTIs was more prevalent in age group of 30-45 years which correlates our findings. Another, UTIs related study in Bangladesh reported that most of the UTIs cases occurred in 21-30 years old (44%) age groups, followed by 41-50 years old (37%) age groups [24].…”

Bacterial Aetiology and Antibiotic Resistance Pattern of Community-Acquired Urinary Tract Infections in Children in a Tertiary Care Hospital in Bangladesh

“…coli isolates were resistant to at least one cephalosporin. Similar rates of antimicrobial resistance were documented in other studies from Bangladesh 19 , Iran 29 and India 30 . However, compared to reports from Nepal, we observed a considerable increase in resistance against penicillins, aminoglycosides, quinolones and ceftriaxone.…”

Frequency, Risk Factors and Antibiotic Sensitivity Pattern of Extended-Spectrum Beta-Lactamase Producing Escherichia coli and Klebsiella pneumoniae Causing Urinary Tract Infection: Experience from a Tertiary Care Hospital of Bangladesh

“…10,[16][17][18][19] Antibiotic sensitivity patterns were also similar. [6][7][8][9][10][16][17][18] Current study had some limitations. It was a single center study, comprising small number of study population over a short period of time and most of our study participants were diabetic.…”

“…[1][2][3][4] In Bangladesh, only a few studies were reported on ESBL-positive organisms, mostly describing their prevalence and antibiotic sensitivity patterns. [5][6][7][8][9] Diabetes mellitus (DM), past history of UTI and prior antibiotic use are reported risk factors for UTI due to ESBL-positive organisms. 10,11 In this study, we have tried to evaluate the frequency of UTI due to ESBL-positive Escherichia coli and Klebsiella pneumoniae, their antibiotic sensitivity patterns and risk factors.…”