Prevalence of fluconazole‐resistant strains of<b><i>Candida albicans</i></b>in otherwise healthy outpatients

Haberland-Carrodeguas, C; Allen, Carl M.; Beck, F. Michael; Buesching, William J.; Koletar, Susan L.; Sundstrom, Paula

doi:10.1034/j.1600-0714.2002.310207.x

Cited by 16 publications

(8 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, C. krusei and C. glabrata were resistant to this drug. These results are consistent to those reported by several authors (8,23,26). On the other hand, itraconazole demonstrated a surprisingly low efficacy against C. albicans isolates.…”

Section: Discussionsupporting

confidence: 83%

Antifungal suscepitibility profile of candida spp. oral isolates obtained from denture wearers

Lyon¹,

Moreira²,

Cardoso³

et al. 2008

Braz. J. Microbiol.

View full text Add to dashboard Cite

Denture stomatitis is an inflammatory condition that occurs in denture wearers and is frequently associated with Candida yeasts. Antifungal susceptibility profiles have been extensively evaluated for candidiasis patients or immunosupressed individuals, but not for healthy Candida carriers. In the present study, fluconazole, itraconazole, voriconazole, terbinafine and 5-flucytosin were tested against 109 oral Candida spp. isolates. All antifungal agents were effective against the samples tested except for terbinafine. This work might provide epidemiological information about Candida spp. drug susceptibility in oral healthy individuals.

show abstract

Section: Discussionsupporting

confidence: 83%

Antifungal suscepitibility profile of candida spp. oral isolates obtained from denture wearers

Lyon¹,

Moreira²,

Cardoso³

et al. 2008

Braz. J. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Nevertheless, fluconazole was speculated to show poor efficacy against Candida isolates, especially C. albicans isolates, as 56.7% of these isolates demonstrated resistance against fluconazole; this finding was not in consistence with previous studies. However, many studies have reported a lower incidence of fluconazole resistance, compared to the present study [22, 23]. In this regard, according to a study by Yenisehirli et al ., the resistance of C. albicans isolates to ketoconazole and fluconazole was estimated at 32% and 34%, respectively [13].…”

Section: Discussioncontrasting

confidence: 51%

Emergence of Azoles Resistance Candida species in Iranian AIDS defined patients with oropharyngeal candidiasis

2015

View full text Add to dashboard Cite

Background and Purpose:Oropharyngeal candidiasis (OPC) and antifungal drug resistance are major health concerns in patients with human immunodeficiency virus (HIV). The increased reports of antifungal resistance and expanding drug therapy options prompted the determination of antifungal susceptibility profile. The present study was performed to determine the antifungal susceptibility of Candida species isolated from AIDS patients with OPC in Iran.Materials and Methods:In total, 100 Candida isolates from the oral cavity of patients with OPC (TCD4 < 200 cells/μL) were obtained and cultured on CHROMagar and Sabouraud’s dextrose agar. All isolates were identified according to the assimilation profile, colony color and other conventional methods. Broth microdilution of antifungal drugs was carried out, according to the methods described in M27-S4 and M44-A guidelines by the Clinical and Laboratory Standards Institute (CLSI). Results:Among 60 Candida albicans (C. albicans) strains, 56.7% were resistant to fluconazole, while 38.3% were resistant to ketoconazole and clotrimazole. The resistance of C. albicans isolates against polyene antifungals including amphotericin B was scarce (1.7%). Based on the results, 52.2% of C. glabrata strains were resistant to fluconazole, while 47.8% and 30.4% of these isolates were resistant to ketoconazole and clotrimazole, respectively. All Candida isolates were susceptible to nystatin and caspofungin.Conclusion:Based on the findings, it can be concluded that screening of resistant Candida isolates by disk diffusion or broth dilution method is essential for the surveillance and prevention of antifungal resistance in patient management. Although nystatin is widely used in clinical practice for HIV patients in Iran, no evidence of enhanced resistance against this agent was found; on the other hand, resistance to azole antifungals, particularly fluconazole, increased. Considering the lack of resistance to caspofungin, administration of this agent is suggested for the treatment of OPC in AIDS patients.

show abstract

“…1 A recent American study has demonstrated no fluconazole-resistant strains of C. albicans in an otherwise healthy population with oral candidosis following treatment with fluconazole. 12 Despite the availability of fluconazole as an overthe-counter medicine, there is not yet any evidence that this has been associated with an increase in resistance; however, there is no national surveillance scheme capable of detecting this. 13 Other antimicrobial agents are available for topical administration in oral candidosis in the form of mouthwashes.…”

Section: Discussionmentioning

confidence: 99%

Patterns of antifungal prescribing in general dental practice

et al. 2004

View full text Add to dashboard Cite

Objective To examine the current practice of antifungal prescribing by GDPs in the United Kingdom. Design A postal questionnaire circulated to a random selection of 400 dentists. Outcome measures The questionnaires were analysed and the responses expressed as absolute and relative frequencies. Results Responses to the questionnaire were received from 297 (74.3%) GDPs. Nystatin was the most popular choice of antifungal agent that GDPs would use, followed by miconazole, amphotericin B and fluconazole. The likelihood of use of miconazole was positively linked to recent date of graduation. Lack of knowledge regarding contraindications and problems with azole antibiotics was found in a significant minority of practitioners (36%). Conclusions The present study indicates that azole antifungal agents (especially miconazole) are becoming more widely used by GDPs, but that knowledge regarding potential problems with their use is suboptimal. Nystatin remains the most popular choice of antifungal agent.Much attention has been focused on the prescribing of antibiotics recently. Such interest has largely examined antibacterial prescribing but there has been less work examining antifungal prescribing. Given that there is increasing evidence of Candida species becoming resistant to some antifungal agents, particularly the azole group, 1 it is timely to examine the current prescribing habits in general dental practice.Lewis et al. 2 investigated the prescribing of antibiotics by general dental practitioners (GDPs) in the United Kingdom in 1987. Since that study, newer azole antifungals, namely fluconazole, have become available in general dental practice. However, the azoles, unlike the polyene antifungals, are absorbed from the gastrointestinal tract and thus have the potential for interactions with other drugs. They also have the potential to be hepatotoxic. Over the last few years four antifungal drugs in a number of formulations, have been available for GDPs to prescribe under NHS regulations. 3 Nysatin is available as pastilles, suspension and ointment for extra-oral use on the skin, while amphotericin is only available in lozenges and suspension for intra-oral use. Miconazole is available as an oral gel as well as an ointment and cream (combined with 1% hydrocortisone) for use on the skin. Fluconazole capsules and suspension are available for oral/systemic use.The aim of the present study was to establish the types and formulations of antifungal agents prescribed by a cross section of general dental practitioners during 1999/2000. We wanted to examine if prescribing habits were influenced by the time since graduation and the possession of postgraduate qualifications. Also, we wished to examine the awareness of practitioners regarding contraindications to, and problems with azole antifungals. MATERIALS AND METHODSThe postal addresses of dental practitioners were obtained from the 1999 UK Dental Register. An initial total of 400 practitioners were selected by choosing every 74th entry in the register. Each of these dentists ...

show abstract

Prevalence of fluconazole‐resistant strains ofCandida albicansin otherwise healthy outpatients

Abstract: Our results showed that the presence of fluconazole-resistant strains of C.albicans does not appear to be prevalent among healthy outpatients furthermore, in vitro antifungal susceptibility testing does not always predict successful therapy in these patients.

Cited by 16 publications

References 37 publications

Antifungal suscepitibility profile of candida spp. oral isolates obtained from denture wearers

Antifungal suscepitibility profile of candida spp. oral isolates obtained from denture wearers

Emergence of Azoles Resistance Candida species in Iranian AIDS defined patients with oropharyngeal candidiasis

Patterns of antifungal prescribing in general dental practice

Contact Info

Product

Resources

About