Prevalence of G2P[4] and G12P[6] Rotavirus, Bangladesh

Rahman, Mustafizur; Sultana, Rasheda; Ahmed, Gehan M.; Nahar, Sharifun; Hassan, Zahid; Saiada, Farjana; Podder, Goutam; Faruque, A. S. G.; Siddique, A. K.; Sack, David A.; Matthijnssens, Jelle; Ranst, Marc Van; Azim, Tasnim

doi:10.3201/eid1301.060910

Cited by 168 publications

(127 citation statements)

References 37 publications

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“…This result was consistent with the previous fi ndings on rotavirus epidemiology in Bangladesh in which its prevalence was ≈29% (11,12). Our study demonstrated 2 peaks of rotavirus infection.…”

Section: Discussionsupporting

confidence: 93%

G2 Strain of Rotavirus among Infants and Children, Bangladesh

Dey¹,

Hayakawa²,

Rahman³

et al. 2009

Emerg. Infect. Dis.

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Section: Discussionsupporting

confidence: 93%

G2 Strain of Rotavirus among Infants and Children, Bangladesh

Dey¹,

Hayakawa²,

Rahman³

et al. 2009

Emerg. Infect. Dis.

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“…Although a reduction in the episodes of gastroenteritis attributable to rotaviruses was seen between 2005 and 2008, it is not clear whether the recent introduction of rotavirus testing and sampling for the current study may be a confounding factor, and only continued surveillance will allow the monitoring of this trend in the long term. [17,18,23,[37][38][39][40][41]. These fluctuations may be driven by herd immunity and the emergence of a particular genotype may reflect the buildup of a sufficiently large population of susceptible children.…”

Section: The Burden Of Rotavirus Diseasementioning

confidence: 99%

Molecular epidemiology of rotaviruses in Bulgaria: annual shift of the predominant genotype

Mladenova

Korsun²,

Geonova³

et al. 2010

Eur J Clin Microbiol Infect Dis

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“…In the tropics, incidence exhibits less pronounced seasonal variation (16, 21), with year-round incidence and peaks during summer or fall following monsoon rains, as in Bangladesh (22,23). Despite these contrasting patterns, few correlational studies have statistically associated environmental variables with rotavirus incidence (24,25). We focus here on the monsoon season, and on flooding in particular, which is both a major environmental disturbance in Bangladesh and one of the more prominent local manifestations Significance Rotavirus is the most common cause of diarrhea among infants and children worldwide, and is still responsible for over 400,000 deaths per year, affecting mainly developing countries.…”

mentioning

confidence: 99%

Differential and enhanced response to climate forcing in diarrheal disease due to rotavirus across a megacity of the developing world

Martinez

King

Yunus

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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The role of climate forcing in the population dynamics of infectious diseases has typically been revealed via retrospective analyses of incidence records aggregated across space and, in particular, over whole cities. Here, we focus on the transmission dynamics of rotavirus, the main diarrheal disease in infants and young children, within the megacity of Dhaka, Bangladesh. We identify two zones, the densely urbanized core and the more rural periphery, that respond differentially to flooding. Moreover, disease seasonality differs substantially between these regions, spanning variation comparable to the variation from tropical to temperate regions. By combining process-based models with an extensive disease surveillance record, we show that the response to climate forcing is mainly seasonal in the core, where a more endemic transmission resulting from an asymptomatic reservoir facilitates the response to the monsoons. The force of infection in this monsoon peak can be an order of magnitude larger than the force of infection in the more epidemic periphery, which exhibits little or no postmonsoon outbreak in a pattern typical of nearby rural areas. A typically smaller peak during the monsoon season nevertheless shows sensitivity to interannual variability in flooding. High human density in the core is one explanation for enhanced transmission during troughs and an associated seasonal monsoon response in this diarrheal disease, which unlike cholera, has not been widely viewed as climate-sensitive. Spatial demographic, socioeconomic, and environmental heterogeneity can create reservoirs of infection and enhance the sensitivity of disease systems to climate forcing, especially in the populated cities of the developing world.M any infectious diseases, especially those infectious diseases that are water-borne and vector-borne, have been shown to exhibit significant interannual variability in the size of seasonal outbreaks (e.g., 1-6). Identification of climate factors shaping interannual and seasonal variability is prerequisite to an understanding of the basic transmission biology of these environmentally driven diseases, and of their response to climate change. The impact of climate factors on the population dynamics of infectious diseases has typically been addressed at large spatial scales by aggregating surveillance data over whole countries, regions, and cities (e.g., 3, 4, 6-8). Global climate drivers, such as the El Niño Southern Oscillation (ENSO), are expected to operate over large spatial scales, synchronizing fluctuations of disease incidence across space [i.e., the Moran effect in population dynamics (9, 10)]. A recent study has shown, however, that the spatiotemporal dynamics of cholera in Dhaka, Bangladesh, are not homogeneous at intraurban scales (11). Two regions or clusters were identified, corresponding, respectively, to the highly populated core and the more rural periphery. The urban core was shown to be more climatesensitive, acting to propagate climate perturbations in cholera infection risk to the r...

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Prevalence of G2P[4] and G12P[6] Rotavirus, Bangladesh

Abstract: Rotavirus strains not covered by licensed vaccines are increasing.

Cited by 168 publications

References 37 publications

G2 Strain of Rotavirus among Infants and Children, Bangladesh

G2 Strain of Rotavirus among Infants and Children, Bangladesh

Molecular epidemiology of rotaviruses in Bulgaria: annual shift of the predominant genotype

Differential and enhanced response to climate forcing in diarrheal disease due to rotavirus across a megacity of the developing world

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