Prevalence of gastric precancerous lesions in Ardabil, a high incidence province for gastric adenocarcinoma in the northwest of Iran

Abstract

Background/Aims: Ardabil Province, in northwestern Iran, has the highest rate of gastric (predominantly cardia) adenocarcinoma in Iran. This study aimed to investigate the feasibility of endoscopic screening and to look for associated Helicobacter pylori infection and gastric precancerous lesions. Methods: One thousand one hundred and five adult volunteers, residents of Ardabil and Meshkinshahr, districts, 40 years old and above were selected and invited by a simple random household canvass in rural and urban locations. Informed consents were obtained and upper gastrointestinal video endoscopy was performed to biopsy all visible lesions and standard sites in the antrum, corpus, and cardia Results: One thousand and eleven of the invited individuals agreed to participate, including 494 men and 517 women, with a mean (SD) age of 53.32 (10.39) years. Endoscopy was well tolerated by all subjects; 96.7% of antral and 80.7% of cardia mucosal biopsies were satisfactory. The urease test or histology for H pylori was positive in at least 89.2% of subjects. Histological evidence of mucosal atrophy was seen in 39.3% of antral and 21.9% of cardia samples. Chronic gastritis with or without activity, reactive atypia of glandular epithelium, intestinal metaplasia, dysplasia, and cancer were found in 95.1%, 38.0%, 8.7%, 0.2%, and 0.3% of antral and 85.3%, 22.9%, 3.8%, 0.3%, and 0.1% of cardiac biopsies, respectively. Conclusion: Endoscopic screening for upper gastrointestinal diseases was feasible and well tolerated in Ardabil, Iran. Most subjects showed H pylori infection. Atrophic gastritis, reactive atypia, and intestinal metaplasia were common in antrum, corpus, and cardia subsites.

Global Prevalence of Helicobacter pylori Infection in Pregnant Women: A Systematic Review and Meta-analysis Study

“…Invasive methods due to ethical issues and UBT because of the use of radioactive materials, are prohibited in pregnancy (35). Invasive methods due to ethical issues and UBT due to the use of radioactive materials are prohibited in pregnancy (35). In most of the studies that investigated the prevalence of H. pylori among pregnant women (80%) based on diagnostic method, serology was the dominant method and this amount was measured to be 49% which had a slight difference with general estimation.…”

“…Invasive methods due to ethical issues and UBT because of the use of radioactive materials, are prohibited in pregnancy (35). Invasive methods due to ethical issues and UBT due to the use of radioactive materials are prohibited in pregnancy (35).…”

Trend Analysis of Gastric Cancer Incidence in Iran and Its Six Geographical Areas During 2000-2005

“…and due to late diagnosis, it is mostly diagnosed in the advanced stages of the disease (Eskandar et al, 2006). Gastric cancer incidence has had a slow increase during three past decades in Iran and in 2002 has increased twice in comparison with the three past decades (Malekzadeh et al, 2004;Sadjadi et al, 2006). The incidence trend of gastric and esophagus cancer has decreased dramatically in the Iranian residents of Canada (Sadjadi et al, 2009) which could be an indication for the high impact of lifestyle and environmental factors in the incidence of stomach cancer.…”

Prevalence of Helicobacter pylori Infection evaluated by Stool antigen test in Khuzestan Province since September to October 2009, south-west of Iran: a population based study

“…A recent study performed by histopathology in Ardabil, northwest of Iran, revealed about 90% of H. pylori infection in the normal population, older than 40 years old (7). There are several techniques available for detection of H. pylori.…”