Prevalence of genital abnormalities in neonates

Monlleó, Isabella Lopes; Zanotti, Susane Vasconcelos; Araújo, Bárbara Priscila B. de; Júnior, Erisvaldo F. Cavalcante; Pereira, Paula dos Santos; Barros, Paulo Mozart de; Araújo, Maria Deysiane Porto; Mendonça, Ana Thaysa V. S. de; Santos, Catarina; Santos, Ylana R. dos; Michelatto, Débora de Paula; Mello, Maricilda Palandi de; Maciel‐Guerra, Andréa Trevas; Guerra‐Júnior, Gil

doi:10.2223/jped.2237

Cited by 12 publications

(11 citation statements)

References 15 publications

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“…Annual rate changes were estimated from the slope of a regression line drawn through the observed values. The significance and linearity of the rate trend were tested following the Cochran and Armitage test to assess for gradient in proportions from several independent, quantitatively ordered samples (as reported by Fleiss) ( 12 ). This analysis was based on the formula:…”

Section: Methodsmentioning

confidence: 99%

ECLAMC Study: prevalence patterns of hypospadias in South America: multi-national analysis over a 24-year period

et al. 2017

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Objective To evaluate prevalence trends of hypospadias in South-America it is essential to perform multicenter and multinational studies with the same methodology. Herein we present systematic data as part of an international multicenter initiative evaluating congenital malformations in South America over a 24-year period.Materials and Methods A nested case-control study was conducted using the Latin American Collaborative Study of Congenital Malformations (ECLAMC), between January 1989 and December 2012. Cases were stratified as isolated (IH) and non-isolated hypospadias (NIH). Global prevalence was calculated and discriminated by country. Associations between birth weight and gestational age, and NIH distribution by associated abnormality and severity of hypospadias, were analyzed.Results A total of 159 hospitals from six countries participated, reporting surveillance on 4.020.384 newborns. A total of 4.537 hypospadias cases were detected, with a global prevalence of 11.3/10.000 newborns. Trend analyses showed in Chile, Brazil and Uruguay a statistically significant increase in prevalence. Analysis of severity and associated anomalies did not to find an association for distal cases, but did for proximal (RR=1.64 [95% CI=1.33-2.03]).Conclusion This is one of only a few Latin American multicenter studies reporting on the epidemiology of hypospadias in South America in the last two decades. Our data adds to evidence suggesting an increase in some countries in the region at different times. There were also variations in prevalence according to severity. This study adds to literature describing associated anomalies at a hospital-based level.

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Section: Methodsmentioning

confidence: 99%

ECLAMC Study: prevalence patterns of hypospadias in South America: multi-national analysis over a 24-year period

et al. 2017

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“…This result may reflect the underdiagnosis and underreporting of GUA, as well as the access difficulty and the disconnection between the health services in the state. 17 , 18 …”

Section: Discussionmentioning

confidence: 99%

“…Esse resultado pode refletir o subdiagnóstico e o sub-registro de AGU, além de dificuldades de acesso e desarticulação dos serviços de saúde no estado. 17 , 18 …”

Section: Discussionunclassified

Profile of patients with genitourinary anomalies treated in a clinical genetics service in the Brazilian unified health system

Gazzaneo

Queiroz

Goes

et al. 2016

Revista Paulista de Pediatria (English Edition)

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Objective: To describe the profile of patients with genitourinary abnormalities treated at a tertiary hospital genetics service.Methods:Cross-sectional study of 1068 medical records of patients treated between April/2008 and August/2014. A total of 115 cases suggestive of genitourinary anomalies were selected, regardless of age. A standardized clinical protocol was used, as well as karyotype, hormone levels and genitourinary ultrasound for basic evaluation. Laparoscopy, gonadal biopsy and molecular studies were performed in specific cases. Patients with genitourinary malformations were classified as genitourinary anomalies (GUA), whereas the others, as Disorders of Sex Differentiation (DSD). Chi-square, Fisher and Kruskal–Wallis tests were used for statistical analysis and comparison between groups.Results:80 subjects met the inclusion criteria, 91% with DSD and 9% with isolated/syndromic GUA. The age was younger in the GUA group (p<0.02), but these groups did not differ regarding external and internal genitalia, as well as karyotype. Karyotype 46,XY was verified in 55% and chromosomal aberrations in 17.5% of cases. Ambiguous genitalia occurred in 45%, predominantly in 46,XX patients (p<0.006). Disorders of Gonadal Differentiation accounted for 25% and congenital adrenal hyperplasia, for 17.5% of the sample. Consanguinity occurred in 16%, recurrence in 12%, lack of birth certificate in 20% and interrupted follow-up in 31% of cases.Conclusions: Patients with DSD predominated. Ambiguous genitalia and abnormal sexual differentiation were more frequent among infants and prepubertal individuals. Congenital adrenal hyperplasia was the most prevalent nosology. Younger patients were more common in the GUA group. Abandonment and lower frequency of birth certificate occurred in patients with ambiguous or malformed genitalia. These characteristics corroborate the literature and show the biopsychosocial impact of genitourinary anomalies.

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“…The congenital reproductive disorder are mostly found in type of hypospadias, enlarged clitoris, micropenis, fusion of labiamajora, and genital ambiguity. 1,2 Corresponding author: Kurnia Penta Seputra; Department of Urology, Faculty of Medicine UniversitasBrawijaya-Saiful Anwar General Hospital, Malang, East Java, Indonesia. Phone: +6281944995539, Fax: +62341333030, Email: urobes.fk@ub.ac.id.…”

Section: Introductionmentioning

confidence: 99%

The Characteristic of Toddlers Reproductive Health in Posyandu Matahari, Blimbing, Malang, East Java, Indonesia

Seputra,

Daryanto,

Prasetyo

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Background & Objective: The screening of reproductive health plays an essential role of early detection of reproductive health disorder. There was a study which suggested that there was at least one congenital disorder every 100 live births. The Congenital reproductive disorder are mostly found in type of hypospadias, enlarged clitoris, micropenis, fusion of labia majora, and genital ambiguity. Data collected in Saiful Anwar General Hospital revealed that period of 2012-2017 there were 109 hypospadias cases, 64 undescended testicle cases, and 80 cases of testicular torsion. However, for the Disorders of Sex Development cases, there were found 12 cases from period of 2015-2017, with mean age was school age (8-14 years old). Unfortunately, there was no data of congenital reproductive disorder in toddlers, thus we conducted screening of toddlers reproductive health in PosyanduMatahari which located in Malang, East Java, Indonesia in order to find out the number of incidence of toddlers congenital reproductive disorder and held the early detection.Materials & Methods: This is observational descriptive study. Screening was held in PosyanduMatahari which located in GedungSerbagunaRw. 14, Bunulrejo, Jodipan, Blimbing, Malang, in October 27, 2018. It used method of physical examination (age, weight, height, external genital examination), and if it was found suspicious of disease or disorder of toddler congential reproductive health, thus it would be given referral to appropriate health care Results: This screening event involved 46 toddlers (1-5 years old). From 46 toddlers, there were 14 toddlers (30.43%), 10 toddlers suffered from Phimosis (21.74%), 1 toddler with Hydrocele (2.17%), dan 3 toddlers suffered from UDT (6.52), who were referred to urology clinic in Saiful Anwar General Hospital to undergo further examination and treatment. Conclusion:The incidence of toddlers reproductive disorder of this event was 30,43%, showed that this age group (1-5 years old) had significant amount of congenital reproductive disorder and screening played important role for early detection and improving parental knowledge to prevent the delay of treatment for reproductive disorder.

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Prevalence of genital abnormalities in neonates

Cited by 12 publications

References 15 publications

ECLAMC Study: prevalence patterns of hypospadias in South America: multi-national analysis over a 24-year period

ECLAMC Study: prevalence patterns of hypospadias in South America: multi-national analysis over a 24-year period

Profile of patients with genitourinary anomalies treated in a clinical genetics service in the Brazilian unified health system

The Characteristic of Toddlers Reproductive Health in Posyandu Matahari, Blimbing, Malang, East Java, Indonesia

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