Prevalence of gestational diabetes mellitus and pregnancy outcomes in Asian women with polycystic ovary syndrome

Weerakiet, Sawaek; Srisombut, Chartchai; Rojanasakul, A; Panburana, Panyu; Thakkinstian, Ammarin; Herabutya, Yongyoth

doi:10.1080/09513590400007242

Cited by 67 publications

(47 citation statements)

References 13 publications

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“…In the present work, also in accordance with previous findings (Vandermolen et al 2001, Harbone et al 2003, Kazerooni & Dehghan-Kooshkghazi 2003, Weerakiet et al 2004, we demonstrate that the administration of metformin together with DHEA prevented the effect of hyperandrogenization, i.e. the increase of serum E and P levels.…”

Section: Discussionsupporting

confidence: 81%

Role of the N, N′-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone

Sander¹,

Luchetti²,

Solano³

et al. 2006

Reproduction

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The present study investigated the role of the N, N{ 0 }-dimethylbiguanide metformin (50 mg/100 g body weight in 0.05 ml water, given orally with a canulla) in the prevention of endocrine and immune disorders provoked by the hyperandrogenization with dehydroepiandrosterone (DHEA) in prepuberal BALB/c mice. The treatment with DHEA (6 mg/100 g body weight in 0.1 ml oil) for 20 consecutive days, recreates a mouse model that resembles some aspects of the human polycystic ovary syndrome (PCOS). The treatment with DHEA did not modify either body mass index (BMI) or blood glucose levels, but did increase fasting insulin levels when compared with controls. Markers of ovarian function -serum estradiol (E), progesterone (P) and ovarian prostaglandin E (PGE) -were evaluated. The treatment with DHEA increased serum E and P levels while ovarian PGE diminished. When metformin was administered together with DHEA, serum insulin, E and P levels, and ovarian PGE values did not differ when compared with controls. Using flow cytometry assays we found that the treatment with DHEA diminished the percentage of the CD4 1 T lymphocyte population and increased the percentage of the CD8 1 T lymphocyte population from both ovarian tissue and retroperitoneal lymph nodes. However, when metformin was administered together with DHEA, the percentages of CD4 1 and CD8 1 T lymphocyte populations from both ovarian tissue and retroperitoneal lymph nodes were similar to those observed in controls. Finally, when DHEA was administered alone it increased the serum tumor necrosis factor-alpha (TNF-a) levels when compared with controls; however, when metformin was administered together with DHEA, serum TNF-a levels were similar to controls. These results indicate that metformin is able, directly or indirectly, to avoid the endocrine and immune alterations produced when mice are hyperandrogenized with DHEA.

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Section: Discussionsupporting

confidence: 81%

Role of the N, N′-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone

Sander¹,

Luchetti²,

Solano³

et al. 2006

Reproduction

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“…Highly related to subfertility and infertility (28), PCO is thus likely to be more common among uniparous compared with biparous women. PCO is associated with increased risks of ovarian cancer (34,35) and preterm birth (36,37) and reduced risk of smallfor-gestational-age birth (38). PCO is also associated with hyperandrogenism and increased IGF-I levels (34), which may also impart effects in the risk of ovarian cancer (17,28).…”

Section: Discussionmentioning

confidence: 99%

Gestational Age and Fetal Growth in Relation to Maternal Ovarian Cancer Risk in a Swedish Cohort

Mucci

Dickman

Lambe

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Pregnancy influences subsequent maternal ovarian cancer risk. To date, there is limited evidence whether two characteristics of pregnancy, gestational age and birth weight, could modify risk. Materials and Methods: We studied 1.1 million Swedish women who delivered singleton births between 1973 and 2001. Information on infant gestational age and birth weight was abstracted from the nationwide Swedish Birth Register. Women were followed prospectively through linkage with other population-based registers for occurrence of ovarian cancer, death, or emigration through 2001. Hazard ratios [relative risk (RR), 95% confidence interval (95% CI)] from Cox models were used to estimate associations between gestational age, birth weight, and epithelial ovarian cancer risk. Results: During 12.6 million person-years, 1,017 epithelial ovarian cancers occurred. Mean age at diagno-

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“…28 More recently, a South-East Asian study confirmed a similar association between GDM, IR and PCOS among Thai women. 29 It is noteworthy that Ehrmann et al who evaluated the predictive value of race and a family history of T2DM on the metabolic status of a large cohort of women with PCOS found that these factors have a substantial impact on the metabolic and glycaemic status of women. They also evaluated these parameters in women without PCOS and found that a positive family history of T2DM correlated with central obesity and IR, which is mirrored in our study.…”

Section: Discussionmentioning

confidence: 99%

Metabolic and polycystic ovary syndromes in indigenous South Asian women with previous gestational diabetes mellitus

Wijeyaratne

Waduge

Arandara

et al. 2006

BJOG

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Objective To determine the risk of metabolic syndrome (MS) and polycystic ovary syndrome (PCOS) in a cohort of indigenous South Asian women with a recent history of gestational diabetes mellitus (GDM).Design Case-control study.Setting Department of Obstetrics & Gynaecology, University of Colombo, Sri Lanka.Sample Two hundred and seventy-four indigenous Sri Lankan women with previous GDM and 168 ethnically matched controls. Of these, 147 with previous GDM and 67 controls not taking hormonal contraception participated in an in-depth endocrine study.Methods Assessing the prevalence of MS and PCOS based on clinical features, biochemistry and ovarian ultrasound examination at 3 years postpartum. Main outcome measures Prevalence of MS and PCOS.Results Women with previous GDM and controls were studied at a mean (range) of 34.6 (13.4-84.1) and 46.5 (17.5-78) months postpartum, respectively. Those with previous GDM had a larger mean ± 95% confidence interval waist circumference (90.9 ± 1.3 versus 81.2 ± 2.8 cm, P = 0.0004) and were more likely to have hypertension (17.6 versus 7.4%, P = 0.001), glucose intolerance (51.7 versus 10.4%, P = 0.00001), hypertriglyceridaemia (16.3 versus 5.9%, P = 0.02) and a lower level of high-density lipoprotein (70 versus 56.7%, P = 0.04) than the controls. Of the women who had GDM, 72 (49%) had MS, 86 (58.5%) had polycystic ovaries and 59 (40%) had PCOS, significantly more than the control women-4 (6%), 9 (13%) and 2 (3%), respectively (P = 0.00001).Conclusions The prevalence of MS and PCOS in indigenous Sri Lankan women 3 years postpartum is significantly higher in those with previous GDM compared with ethnically matched controls. This confirms an association between GDM and subsequent PCOS and MS.

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Prevalence of gestational diabetes mellitus and pregnancy outcomes in Asian women with polycystic ovary syndrome

Cited by 67 publications

References 13 publications

Role of the N, N′-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone

Role of the N, N′-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone

Gestational Age and Fetal Growth in Relation to Maternal Ovarian Cancer Risk in a Swedish Cohort

Metabolic and polycystic ovary syndromes in indigenous South Asian women with previous gestational diabetes mellitus

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