Prevalence of healthcare-associated infections and antimicrobial resistance in acute care hospitals in Kyiv, Ukraine

Salmanov, Aidyn G; Vozianov, S.O.; Kryzhevsky, V.; Litus, Oleksandr; Drozdova, A. O.; Vlasenko, I. O.

doi:10.1016/j.jhin.2019.03.008

Cited by 42 publications

(39 citation statements)

References 18 publications

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“…According to Salmanov's et al, [19] study, the most common types of HAI were pneumonia and lower respiratory tract infections (19.4% and 4.1%), surgical wound infections (19.6%), infections of urinary tract (17.5%) and sepsis (10.6%). Of the 232 patients with clinical sepsis, 104 were newborns.…”

Section: Discussionmentioning

confidence: 98%

Healthcare Associated Infections—A New Pathology in Medical Practice?

Voidăzan

Albu

Tóth³

et al. 2020

IJERPH

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Background: Hospital-acquired infections (HAI) contribute to the emotional stress and functional disorders of the patient and in some cases, can lead to a state of disability that reduces quality of life. Often, HAI are one of the factors that lead to death. The purpose of this study was to analyze the cases of HAI identified in public hospitals at the county level, through case report sheets, as they are reported according to the Romanian legislation. Methods: We performed a cross sectional study design based on the case law of the data reported to the Mures Public Health Directorate, by all the public hospitals belonging to this county. We tracked hospital-acquired infections reported for 2017-2018, respectively, a number of 1024 cases, which implies a prevalence rate of 0.44%, 1024/228,782 cases discharged from these hospitals during the studied period. Results: The most frequent HAIs were reported by the intensive care units (48.4%), the most common infections being the following: bronchopneumonia (25.3%), enterocolitis with Clostridioides difficile (23.3%), sepsis, surgical wound infections and urinary tract infections. At the basis of HAI were 22 pathogens, but the five most common germs were Clostridioides difficile, Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus. Bronchopneumonia have been most frequently reported in intensive care units, the most common being identified the Acinetobacter baumannii agent. Sepsis and central catheter infections also appeared predominantly in intensive care units, more often with Klebsiella pneumoniae. The enterocolitis with Clostridioides difficile, were the apanage of the medical sections. Infections with Staphylococcus aureus have been identified predominantly in the surgical sections at the level of the surgical wounds. Urinary infections had a similar distribution in the intensive care units, the medical and surgical sections, with Klebsiella pneumoniae being the most commonly incriminated agent. Conclusions: We showed a clear correspondence between the medical units and the type of HAI: what recommends the rapid, vigilant and oriented application of the prevention and control strategies of the HAI. Author Contributions: Data curation, S.V., S.A. and I.M.; Funding acquisition, B.G. and A.R.; Investigation, S.V., Réka Toth and I.M.; Methodology, S.V. and S.A.; Resources, R.T., B.G., A.R. and I.M.; Supervision, S.V., S.A. and I.M.; Visualization, R.T. and B.G.; Writing-original draft, S.V. and A.R.; Writing-review and editing, S.A. and B.G. All authors have read and agreed to the published version of the manuscript. Funding: This research received no external funding. Conflicts of Interest:The authors declare no conflict of interest.

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Section: Discussionmentioning

confidence: 98%

Healthcare Associated Infections—A New Pathology in Medical Practice?

Voidăzan

Albu

Tóth³

et al. 2020

IJERPH

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“…and reporting [6,[12][13][14]. Previous studies have reported the incidence of postpartum mastitis to be as high as 33% in lactating women [2,[6][7][8][9][10][11][12][13][14]. The majority of cases occur in the first eight weeks (two months) postpartum, but mastitis can occur at any time during breastfeeding [2,[13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

“…However, the epidemiology of mastitis in breastfeeding women in Ukraine and associated treatment outcomes are not well studied. National network for the surveillance of antimicrobial resistance is not in Ukraine [9,10]. Postpartum mastitis problems experienced by Ukrainian breastfeeding women's have not been reported previously.…”

Section: Introductionmentioning

confidence: 92%

Postpartum Mastitis in the Breastfeeding Women and Antimicrobial Resistance of Responsible Pathogens in Ukraine: Results a Multicenter Study

et al. 2020

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The aim: To obtain the prevalence of mastitis in the breastfeeding women and antimicrobial resistance of responsible pathogens in Ukraine. Materials and methods: A retrospective multicenter cohort study was based on surveillance data for Postpartum Mastitis and included 18,427 breastfeeding women’s who gave birth in 11 regional hospitals of Ukraine. Results: 22.6% breastfeeding women’s were found to have breast infections. Among these patients, 11.6% breast abscess and 88.4% mastitis were observed. Of the total cases breast infections, 74.8% were detected after hospital discharge. The rate of healthcare-associated mastitis was 8.6%. The predominant pathogens were: Staphylococcus aureus (23.6%), Escherichia coli (19.4%), Enterobacter spp. (11.9%), Staphylococcus epidermidis (10.7%), Klebsiella spp. (8.7%), Pseudomonas aeruginosa (4.8%), Enterococcus faecalis (4.8%), and Proteus mirabilis (4.6%). The overall proportion of methicillin-resistance was observed in 27.9% of S. aureus (MRSA) and 24.3% of S. epidermidis (MRSE). Of the total methicillin-resistance strains, 74.8% of MRSA and 82.1% of MRSE is community-acquired, were detected after hospital discharge. Vancomycin resistance was observed in 9.2% of isolated enterococci. Carbapenem resistance was identified in 7.3% of P.aeruginosa isolates. Resistance to third-generation cephalosporins was observed in 8.8% Klebsiella spp. and E.coli 9.1% isolates. Conclusions: Mastitis in the breastfeeding women in Ukraine requires medical attention it is common, and a lot of cases are caused by pathogens resistant to antibiotics. Optimizing the management and empirical antimicrobial therapy may reduce the burden of mastitis, but prevention is the key element.

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“…However, the epidemiology of postpartum endometritis in Ukraine and associated treatment outcomes are not well studied. National network for the surveillance of antimicrobial resistance is not in Ukraine [15,16].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Postpartum Endometritis and Antimicrobial Resistance of Responsible Pathogens in Ukraine: Results a Multicenter Study (2015-2017)

et al. 2020

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The aim: To obtain the prevalence of postpartum endometritis women and antimicrobial resistance of responsible pathogens in Ukraine. Materials and methods: We performed a retrospective multicenter cohort study. The study population consisted of all women who had a vaginal delivery or cesarean section in 14 Regional Women’s Hospitals of Ukraine. Results: Total 2460 of 25,344 patients were found to have postpartum endometritis, for an overall infection rate of 9.7%. The postpartum endometritis rates were 7.6% after vaginal delivery and 16.4% after cesarean section. Incidence of postpartum endometritis after cesarean section is affected mainly by the mode of delivery (scheduled caesarean deliveries (done before labor starts) – 13.8% and unscheduled caesarean deliveries (done after labor starts) – 22.5%. The predominant pathogens were: Escherichia coli (32.7%), Enterococcus faecalis (13.0%), Streptococcus spp. (12.1%), Klebsiella spp. (10.4%) and Enterobacter spp. (10%). Among the antimicrobial agents tested, the ertapenem, piperacillin/ tazobactam, and cefotaxim were the most consistently active in vitro against Enterobacteriaceae in both vaginal deliveries and after cesarean section infections. The overall proportion of extended spectrum beta-lactamase (ESBL) production among Enterobacteriaceae was 22.8% and of methicillin-resistance in Staphylococcus aureus (MRSA) 15.4%. Conclusions: Postpartum endometritis and antimicrobial resistance of responsible pathogens presents a significant burden to the hospital system. Postpartum infections surveillance is required in all women’s hospitals. This knowledge is essential to develop targeted strategies to reduce the incidence of postpartum infections.

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Prevalence of healthcare-associated infections and antimicrobial resistance in acute care hospitals in Kyiv, Ukraine

Cited by 42 publications

References 18 publications

Healthcare Associated Infections—A New Pathology in Medical Practice?

Healthcare Associated Infections—A New Pathology in Medical Practice?

Postpartum Mastitis in the Breastfeeding Women and Antimicrobial Resistance of Responsible Pathogens in Ukraine: Results a Multicenter Study

Prevalence of Postpartum Endometritis and Antimicrobial Resistance of Responsible Pathogens in Ukraine: Results a Multicenter Study (2015-2017)

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