Prevalence of Helicobacter pylori infection and intestinal parasitosis in children of the Xingu Indian Reservation

Escobar-Pardo, Mario Luis; Godoy, Anita Paula Ortiz de; Machado, Rodrigo Strehl; Rodrigues, Douglas; Neto, Ulysses Fagundes; Kawakami, Elisabete

doi:10.2223/jped.2118

Cited by 28 publications

(26 citation statements)

References 31 publications

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“…As previously appointed by other Brazilian researches, 66% of our study population presented H. pylori's infection, among these patients, nearly 58% reported less than 9 years of study. This finding has been also observed in other studies and possibly indicates socioeconomic status and years of study as important conditions associated to the risk factors for H. pylori's transmission (9,33) . According to data previously reported (Kodaira et al), our findings support that H. pylori frequency is not related with smoking habit or alcohol consumption (20) .…”

Section: Discussionsupporting

confidence: 88%

Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

Andreolla

Bona

Sander

et al. 2016

Arq. Gastroenterol.

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-Background -Recently, a great variety of studies aimed to investigate and even suggest Helicobacter pylori as an important key factor in gastrointestinal and non-gastrointestinal events development. The well-established relationship between bacterial virulence and increased risk for peptic ulcer or gastric carcinoma is not so clear when comparing inflammation markers alterations, such C-reactive protein, with the pathogen. Objective -The objective of this study was to evaluate the presence of H. pylori, bacterial virulence and C-reactive protein serum levels in individuals diagnosed with functional dyspepsia. Methods -Were prospectively included in this study 489 dyspeptic individuals. They fulfill Rome III clinical criteria for the diagnosis of functional dyspepsia with no organic disease at endoscopy. The bacterial infection was established by histology and urease rapid test. The levels of serum C-reactive protein were obtained by immunonefelometry and CagA status of H. pylori positive individuals was determined through an imunoenzimatic assay. Results -Prevalence rate of H. pylori was 66.3% and virulence factor CagA was detected in nearly 43% of positive samples. In addition, it has been noticed an association between Ilex paraguariensis (yerba maté) consumption and pathogen's prevalence. An important effect of bacterial infection on inflammation was only observed in gastric epithelium. Conclusion -No systemic response to the pathogen, measured through C-reactive protein levels, was observed, regardless of CagA status. Otherwise, the intake of yerba maté should be considered as a cultural factor possibly related to H. pylori's transmission. According to the recent reports, CagA positive strains can cause severe damage to the gastric epithelium, being related specially with increased levels of interleukin-8 (IL-8), gastroduodenal ulcers and gastric neoplasia occurrence (26,29,41) . In addition, this virulence factor has been associated with systemic inflammation, resulting in high serum C-reactive protein (CRP) levels and the bacteria presence being related to higher cardiovascular risks (21,37) . Some behaviors have been associated to the transmission of H. pylori. Studies have reported that several aspects can be related to incidence and prevalence rates like socioeconomic status, years of study, institutionalization practice or social habits (8,20) . In 2010, a Brazilian study has demonstrated an anti-H. pylori activity of plant extracts, like yerba maté tea (Ilex paraguariensis), but no association between bacteria prevalence and tea consumption has been previously described (6) . Andreolla HF, Bona LR, Sander GB, Mazzoleni LE, Tavares RG, Prolla JC. Lack of association between Helicobacter pylori's virulence and increased serum C-reactive protein levels in functional dyspeptic patients HEADINGS - 50Arq Gastroenterol v. 53 no. 1 -jan./mar. 2016All H. pylori's infected people present histological gastritis. Moreover, the bacteria, classified as type I carcinogen (32) , has been associated with the...

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Section: Discussionsupporting

confidence: 88%

Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

Andreolla

Bona

Sander

et al. 2016

Arq. Gastroenterol.

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“…The infection is acquired in the first years of life in early childhood, but acquisition among low socioeconomic level populations is more frequent before they are 5 years of age [19,20,21]. Although the exact transmission mechanism remains unclear, person-to-person transmission seems to be the main form of dissemination.…”

Section: Epidemiologymentioning

confidence: 99%

Clinical Management of <b><i>Helicobacter pylori</i></b>: The Latin American Perspective

Coelho

Coelho²

2014

Dig Dis

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In most South American countries, Helicobacter pylori infection prevalence is high, affecting over 70% in populations with precarious living conditions. It is worth pointing out that there is initial evidence of a decline in prevalence of H. pylori infection at least in some more privileged fragments of the population. It is estimated that gastric cancer, the main clinical sequela of H. pylori infection, has an average incidence rate of 12.4 cases per 100,000 inhabitants (8.4 cases per 100,000 inhabitants for women and 17.3 cases per 100,000 for men) in the region. Classical triple therapy [proton pump inhibitor (PPI), amoxicillin and clarithromycin] is still the most used regimen with eradication rates around 80%. The rates of resistance to clarithromycin range from 2 to 24%. Recurrence rates of the infection are described as 2.9% in Argentina, 4.2% in Chile, 2-7% in Brazil, and 11.5% in a trial involving 7 Latin American countries. After failure of clarithromycin-containing regimens, second- and third-line therapies using PPI, amoxicillin and levofloxacin and quadruple therapy with PPI, colloidal bismuth subcitrate, tetracycline hydrochloride and metronidazole are recommended.Due to the high rates of primary resistance to metronidazole in the Latin American countries, use of the quadruple therapy, replacing metronidazole for furazolidone, is a frequent option. Rescue triple therapy regimens using furazolidone in association with levofloxacin and PPI have also been used. Most recommended rescue therapies reach eradication rates close to 80%.

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“…In populations with a higher SES, the risk of acquiring it also begins early, although more slowly, reaching significantly lower rates than those seen in populations with a low SES. Acquiring the infection during childhood may be decisive to the morbidity and mortality associated with chronic H pylori infection in the adult population (49,140,156,162) .…”

Section: Group 5 Epidemiology Of Infection and Proposals For Action mentioning

confidence: 99%

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Coelho

Maguinilk

Zaterka³

et al. 2013

Arq. Gastroenterol.

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Significant progress has been obtained since the Second Brazilian Consensus Conference on Helicobacter pylori Infection held in 2004, in São Paulo, SP, Brazil, and justify a third meeting to establish updated guidelines on the current management of H. pylori infection. The Third Brazilian Consensus Conference on H pylori Infection was organized by the Brazilian Nucleus for the Study of Helicobacter, a Department of the Brazilian Federation of Gastroenterology and took place on April 12-15, 2011, in Bento Gonçalves, RS, Brazil. Thirty-one delegates coming from the five Brazilian regions and one international guest, including gastroenterologists, pathologists, epidemiologists, and pediatricians undertook the meeting. The participants were allocated in one of the five main topics of the meeting: H pylori, functional dyspepsia and diagnosis; H pylori and gastric cancer; H pylori and other associated disorders; H pylori treatment and retreatment; and, epidemiology of H pylori infection in Brazil. The results of each subgroup were submitted to a final consensus voting to all participants. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. Seventy per cent and more votes were considered as acceptance for the final statement. This article presents the main recommendations and conclusions to guide Brazilian doctors involved in the management of H pylori infection.

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Prevalence of Helicobacter pylori infection and intestinal parasitosis in children of the Xingu Indian Reservation

Cited by 28 publications

References 31 publications

Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

Clinical Management of <b><i>Helicobacter pylori</i></b>: The Latin American Perspective

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

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