Prevalence of Helicobacter Pylori Infection and Its Link to Coronary Risk Factors in Japanese Patients With Acute Myocardial Infarction

Kinjo, Kunihiro; Sato, Hiroshi; Sato, Hideyuki; Shiotani, Issei; Kurotobi, Toshiya; Ohnishi, Yozo; Hishida, Eiji; Nakatani, Daisaku; Mizuno, Hiroya; Sasaki, Tatsuya; Kohama, Akio; Abe, Yukichi; Morita, Hisaki; Kubo, Mitsuaki; Takeda, Hiroshi; Hori, Masatsugu

doi:10.1253/circj.66.805

Cited by 50 publications

(31 citation statements)

References 41 publications

(39 reference statements)

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“…Our other purpose was to evaluate the role of HP seropositivity in different clinical types of CAD. Although some of the previous studies have shown an association between high HP IgG titers and acute coronary syndromes [18,19], other studies failed to demonstrate this [20]. In our study, although CRP levels were significantly higher in patients with acute coronary syndromes than in those with chronic CAD, prevalence of HP was similar between the groups.…”

Section: Discussioncontrasting

confidence: 67%

Helicobacter pylori Seropositivity in Patients with Acute Coronary Syndromes

et al. 2008

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The aim of this study was to investigate the seroprevalence of Helicobacter pylori (HP) in patients with coronary atherosclerosis and acute coronary syndromes. We enrolled 152 patients (group I, 73 patients with acute coronary syndrome; group II, 79 patients with chronic stable angina) and 22 control subjects. An enzyme-linked immunosorbent assay for immunoglobulin (Ig) G test for HP diagnosis was used on all enrolled subjects. C-reactive protein (CRP) was also measured in all patients as an inflammatory marker. Seropositivity rates for HP were significantly higher in patients with coronary artery disease than in controls (80.2% versus 54.5%; P < 0.05). Although CRP level was significantly higher in group I than in group II (1.72 +/- 2.89 mg/dl versus 0.53 +/- 0.63 mg/dl, P < 0.0001), HP infection rates were similar between groups (86.3% versus 74.6%, P > 0.05). Infection with HP may influence atherogenesis through low-grade, persistent inflammatory stimulation. However, our data show evidence of increased systemic inflammation in patients with acute coronary syndrome, which was unrelated to an increased HP seropositivity.

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Section: Discussioncontrasting

confidence: 67%

Helicobacter pylori Seropositivity in Patients with Acute Coronary Syndromes

et al. 2008

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“…Although a recent metaanalysis found no significant association between Helicobacter pylori seropositivity and coronary heart disease [36], several Japanese studies have revealed a positive association [37][38][39]. Furthermore, we have found a significant association between H. pylori seropositivity and baPWV elevation, and a combination of hs-CRP elevation and H. pylori seropositivity shows a stronger association with baPWV elevation [40].…”

Section: Inflammation and Hs-crpcontrasting

confidence: 67%

Inflammation as a cardiovascular risk factor and pulse wave velocity as a marker of early-stage atherosclerosis in the Japanese population

Saijo

Utsugi

Yoshioka

et al. 2009

Environ Health Prev Med

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Inflammation and pulse wave velocity (PWV) are a potential risk factor and marker, respectively, for atherosclerosis in the primary prevention setting. Atherosclerosis is now generally accepted to be an inflammatory disorder of the arterial wall, and the high-sensitivity Creactive protein (hs-CRP) level has been reported to be a strong predictor of cardiovascular events. High-sensitivity-CRP is associated with two factors related to inflammation: (1) the local production of CRP by atheromatous tissue or coronary artery smooth muscle cells and (2) adipose tissue as a potent source of inflammatory cytokines. Based on studies in North America and Europe, hs-CRP has been established as a cardiovascular risk factor and a cut-off value has been recommended. However, Japanese have lower hs-CRP values than their Western counterparts, partly because Japanese have a lower body mass index (BMI), which correlates positively to hs-CRP, and partly because lifestyle and genetic factors can affect hs-CRP values. Therefore, a cut-off value needs to be established by cohort studies for the Japanese population. Carotidfemoral PWV is most commonly measured by applanation tonometry, particularly in Europe, but this method is critically dependent upon the accurate placing of transducers over the arteries and is both time-consuming and complex. A novel device has been recently developed in Japan that measures brachial-ankle PWV (baPWV) using a volumerendering method. Brachian-ankle PWV is a suitable screening method because of its technical simplicity and shorter measurement time. It is associated not only with conventional cardiovascular risk factors but also with new risk factors, such as inflammation, c-glutamyltransferase, chronic kidney disease, and psychosocial factors. However, a suitable cut-off value has yet to be established.

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“…But a recent meta-analysis revealed only limited evidence of a positive relationship (5). Meanwhile, in a case control study of a Japanese population, H. pylori seropositivity was significantly associated with acute myocardial infarction (AMI) in subjects < 55 years (OR 2.97), but was not associated with AMI for subjects aged ≥ 55 years (55−64 years: OR 1.03; > 65 years: OR 0.79) (15). Another Japanese case-control study showed that H. pylori seropositivity was significantly associated with coronary heart disease (OR 1.34) (16).…”

Section: Discussionmentioning

confidence: 99%