Prevalence of Helicobacter pylori infection in Warao lineage communities of Delta Amacuro State, Venezuela

Objective: To evaluate the prevalence of Helicobacter pylori infection and its association with intestinal parasitoses in children from indigenous communities of the Xingu Indian Reservation, in Brazil.Methods: A total of 245 Native Brazilian children between 2 and 9 years of age, from six villages of the Xingu River region, a tributary of the Amazon River, were assessed. H. pylori was detected using the 13 C-urea breath test. Breath samples were collected at baseline and 30 minutes after ingestion of 50 mg of 13 C-urea diluted with 100 mL of water flavored with passion fruit juice and sweetener. Stool samples were collected for the stool ova and parasites exam for 202/245 (82.4%) children. Results:The overall prevalence of H. pylori was 73.5%. A significant association of H. pylori with increased age was observed among the different villages and ethnic groups. Positive results for the presence of parasites -97.5% (198/202) -from the stool samples collected showed no association with H. pylori. Giardia showed an association with H. pylori in the multivariate analysis. Risk factors for H. pylori infection were observed in Kisêjê and Kaibi ethnic groups (OR [odds ratio] = 3.36 and 4.00, respectively), as well as in Tuiararé, Ngojwere, Capivara, Diauarum, and Pavuru villages (OR = 8.10, 4.10, 4.88, 1.85, and 1.40, respectively). Conclusions:H. pylori infection is highly prevalent in these communities, as well as intestinal parasitoses. However, there were significant differences in the prevalence of H. pylori among the diverse villages studied. Giardia was closely associated with H. pylori infection. J Pediatr (Rio J). 2011;87(5):393-8: Epidemiology, prevalence,Helicobacter pylori, giardia. ResumoObjetivo: Avaliar a prevalência da infecção por Helicobacter pylori e sua associação com parasitoses intestinais em crianças da comunidade indígena do Parque Indígena do Xingu. Métodos:Foram incluídas 245 crianças indígenas entre 2 e 9 anos, de seis aldeias da região do rio Xingu, afluente do Amazonas. H. pylori foi detectado pelo teste respiratório com ureia-13 C. Foram coletadas amostras de ar expirado, em jejum e 30 minutos após a ingestão de 50 mg de ureia-13 C diluída em 100 mL de água aromatizada com suco de maracujá. Foram coletadas amostras de fezes de 202/245 (82,4%) crianças para exame protoparasitológico. Conclusões: Foi encontrada alta prevalência de H. pylori e de parasitose intestinal em crianças nas comunidades presentemente investigadas. No entanto, houve diferença significativa na prevalência do H. pylori entre as diversas aldeias estudadas. Verificou-se associação entre a presença de giárdia e a infecção por H. pylori.

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“…Medidas preventivas facilitarão o desenvolvimento de estratégias para a redução da prevalência dessa infecção nessas populações 17 .…”

Section: Discussionunclassified

Prevalence of Helicobacter pylori infection and intestinal parasitosis in children of the Xingu Indian Reservation

Escobar-Pardo¹,

Godoy²,

Machado³

et al. 2011

J Pediatr (Rio J)

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“…Previous studies of serological prevalence of H. pylori infection in Warao Amerindian populations of the Orinoco Delta region showed values ranging from 65% to 84% for H. pylori whole cell and CagA antigens, and anti-H. pylori IgG antibodies. 14,15 The aim of this study was to assess the prevalence of H. pylori infection and virulence-associated cagA gene in string-absorbed gastric juice samples in two groups of symptomatic mestizo populations. The study involved one group from Tucupita village in the Orinoco Delta region, carried out in November 2012 and another from the capital city of Caracas, carried out between July and November 2011.…”

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confidence: 99%

Helicobacter pylori Infection in Rural and Urban Dyspeptic Patients from Venezuela

Contreras

Fernández-Delgado

Reyes

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. The goal of this work was to assess the Helicobacter pylori prevalence in a rural mestizo population and compare it to an urban population from Venezuela. The study was performed in gastric juice samples of 71 dyspeptic patients from Caracas (urban) and 39 from Tucupita (rural), in the Orinoco Delta region. Helicobacter pylori was detected by amplification of 16S rRNA, glmM, and ureA genes in 55.0% patients from urban and 87.2% from rural populations. cagA was found positive in 51% and 62% urban and rural patients, respectively. Non-H. pylori Helicobacter species were not detected in the urban population, but was found in 7.7% of patients in the rural study site. Frequency values of the 16S rRNA, glmM, and ureA genes were higher in the rural population. The odds ratio for each gene was 15.18 for 16S rRNA, 2.34 for glmM, 2.89 for ureA, and 1.53 cagA, showing significant differences except for cagA when gene frequency was compared in both populations. These results demonstrate a higher frequency of H. pylori and gastric non-H. pylori Helicobacter infection in a rural mestizo population with low hygienic standards as compared with city dwellers, representing a potential risk for the development of gastroduodenal diseases.

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“…Os fatores de risco associados às altas prevalências de parasitoses, como ausência de saneamento básico, ingestão de água não tratada e determinados hábitos de higiene pessoal, culturais e dietéticos, como comer com as mãos, defecar no ambiente, ausência de métodos de conservação dos alimentos, não usar calçados, dentre outros, são variáveis frequentemente observadas nas comunidades indígenas [11][12][13] . A população estudada apresenta alto risco de contrair a infestação ou tornar-se infestada a qualquer momento durante a infância.…”

Section: Discussionunclassified

Prevalence of intestinal parasitoses in children at Parque Indígena do Xingu

Escobar-Pardo¹,

Godoy²,

Machado³

et al. 2010

J Pediatr (Rio J)

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Objective: To evaluate the prevalence of intestinal parasitoses in Native Brazilian children from 2 to 9 years old. Methods:A search for ova and parasites was conducted in the stools of children between 2 to 9 years old living in six indigenous villages located in the Middle and Lower Xingu River, to wit: Pavuru, Moygu, Tuiararé, Diauarum, Capivara, and Ngojwere. The study utilized the Paratest ® kit (Diagnostek, Brazil) to preserve collected stools. Fecal samples were shipped to the Laboratory of the Pediatric Gastroenterology Division of the UNIFESP/EPM, in São Paulo, for analysis. The search for ova and parasites was performed utilizing the Hoffman method, and later through optical microscopic evaluation. Fecal samples were collected one year apart from each other.Results: There were no significant statistical differences between the mean ages of the children from the six indigenous villages studied. The search for ova and parasites found positive results for the stools of 97.5% (198/202) and 96.1% (98/102) of children in the first and second collections, respectively. There was no statistical association with the children's age. The search performed one year later found no differences in the proportion of parasites identified in the first collection for protozoa Conclusion:The high prevalence of intestinal parasitosis matched the elevated rates of environmental contamination in this indigenous community. J Pediatr (Rio J). 2010;86(6):493-496:Epidemiology, prevalence, ancylostoma, giardia, Schistossoma. ResumoObjetivo: Avaliar a prevalência da parasitose intestinal em crianças indígenas de 2 a 9 anos.Métodos: Para a realização do exame protoparasitológico, foram convidadas todas as crianças de 2 a 9 anos, de seis aldeias localizadas no Médio e Baixo Xingu: Pavuru, Moygu, Tuiararé, Diauarum, Capivara e Ngojwere. Para a conservação das amostras de fezes, foi utilizado o kit coletor Paratest ® (Diagnostek, Brasil). As amostras foram transportadas para São Paulo. A pesquisa de helmintos e protozoários foi feita através do método de Hoffman, com posterior pesquisa de ovos e cistos por microscopia óptica. Foram feitas duas coletas com intervalo de 1 ano.Resultados: Não houve diferença significativa entre as idades médias das crianças provenientes das seis aldeias. Resultaram positivas para a presença de parasitas, 97,5% (198/202) Conclusão: A alta prevalência de parasitose intestinal foi compatível com o alto índice de contaminação ambiental dessa comunidade.

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Prevalence of Helicobacter pylori infection in Warao lineage communities of Delta Amacuro State, Venezuela

Cited by 15 publications

References 27 publications

Prevalence of Helicobacter pylori infection and intestinal parasitosis in children of the Xingu Indian Reservation

Prevalence of Helicobacter pylori infection and intestinal parasitosis in children of the Xingu Indian Reservation

Helicobacter pylori Infection in Rural and Urban Dyspeptic Patients from Venezuela

Prevalence of intestinal parasitoses in children at Parque Indígena do Xingu

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