Prevalence of Helicobacter Pylori Infection and Stress, Anxiety or Depression in Functional Dyspepsia and Outcome after Appropriate Intervention

Kabeer, Kirti Katherine; Ananthakrishnan, N; Anand, Chetan; Balasundaram, Sivaprakash

doi:10.7860/jcdr/2017/26745.10486

Cited by 17 publications

(15 citation statements)

References 29 publications

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“…In our study, decrease in the dyspepsia symptom scores with the PPI (esomeprazole) with or without antibiotics at the 8th week and despite the discontinuation of treatment for 8 weeks, no increase in the scores suggests that there is no placebo effect. In an adult study, it has shown that H. pylori and stress, anxiety, and depression had high prevalence in FD . Psychological and social supports, and complementary therapies should be combined with the medications .…”

Section: Discussionmentioning

confidence: 99%

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The effect of Helicobacter pylori eradication on functional dyspepsia in Turkish children

et al. 2018

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Although the tests used for the diagnosis of H. pylori in functional dyspeptic patients increased the cost of health care, the dyspepsia symptom scores decreased with the eradication therapy in a high prevalence community. The findings may differ in low prevalence communities where the diagnostic tests for H. pylori infection are not recommended in children in the absence of alarm signs or symptoms.

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Section: Discussionmentioning

confidence: 99%

“…In an adult study, it has shown that H. pylori and stress, anxiety, and depression had high prevalence in FD. 25 Psychological and social supports, and complementary therapies should be combined with the medications. 26 In various ethnic and racial backgrounds, the responses of eradication are different.…”

Section: Discussionmentioning

confidence: 99%

The effect of Helicobacter pylori eradication on functional dyspepsia in Turkish children

et al. 2018

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“…They concluded that psychiatric illness should be considered for patients who fail the treatment of symptoms after H. pylori eradication, as it will affect their treatment [35]. A prospective study by Kabeer et al to determine the prevalence of H. pylori and depression in patients with functional dyspepsia and to assess the outcome in three months after appropriate intervention enrolled 120 patients with functional dyspepsia, who underwent upper endoscopy to confirm H. pylori infection with either of two tests- the urease test or histopathology [36]. Adding to that, patients had a patient health questionnaire-9 scale (PHQ-9) to assess depression.…”

Section: Reviewmentioning

confidence: 99%

The Psychotic Impact of Helicobacter pylori Gastritis and Functional Dyspepsia on Depression: A Systematic Review

Quraan

Beriwal

Sangay

et al. 2019

Cureus

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The clinical practice of adding antidepressant drugs to the therapy for the eradication of Helicobacter pylori (H. pylori) in addition to the standard drug regimen is not yet well established. This study aims to establish if there is an association between H. pylori gastritis and depression and to further analyze the therapeutic effect of antidepressants on symptomatic relief in gastritis. A systematic review was done using articles collected within the last seven years without regional or language localization obtained using PubMed, PubMed Central® (PMC), Google Scholar, and the Cochrane controlled trials. The search terms included Helicobacter pylori, depression, functional dyspepsia, and antidepressants. We selected three randomized controlled trials (RCTs), eight cross-sectional studies, four prospective studies, one cohort study, and two review articles. Trials that were prescribed antidepressants for clinical improvement of dyspepsia in patients with H. pylori gastritis that showed no improvement after eradication therapy standard regimen were included. In conclusion, patients who showed no improvement in functional dyspepsia after H. pylori eradication were seen to improve on antidepressant therapy. Further investigation and studies to analyze this correlation are recommended.

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“…When a decrease of 4 or more was considered as an indicator of significant response to intervention, an overall 74.2% responded with the best response in Group B and the poorest in Group C. The authors concluded that appropriate intervention is beneficial except for those who are H. pylori negative and SAD positive. This latter group requires further investigation and/or drug intervention for SAD …”

Section: Helicobacter Pylori Infection and Dyspepsiamentioning

confidence: 99%

Helicobacter pylori and nonmalignant upper gastrointestinal diseases

2018

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The review of the most important recent publications concerning the relation of Helicobacter pylori with peptic ulcer disease (PUD), noninvestigated and functional dyspepsia, and gastroesophageal reflux disease (GERD) is presented. H. pylori remains the main etiopathogenetic factor in complicated and uncomplicated PUD. Nevertheless, the role of nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin is increasing. The novel data did not confirm that PUD caused by NSAIDs and aspirin is less symptomatic. The role of glucocorticoids, immunosuppressants, and antidepressants seems to be of some importance. Although the involvement of H. pylori in functional dyspepsia is controversial, several data support the importance of H. pylori-induced gastritis in the pathogenesis of dyspeptic symptoms. Recent interventional studies have reported that H. pylori eradication improves dyspepsia mainly in areas with a high prevalence of this bacterium. Novel data regarding the relation of gastrointestinal peptides, ghrelin and obestatin, with H. pylori infection are also presented. Intriguing findings support the involvement of the gastric microbiota in the causation of chronic functional dyspepsia. Finally, some data concerning negative, positive, or neutral associations of H. pylori with gastroesophageal reflux disease (GERD) were published. In this context, today there is no evidence indicating that H. pylori eradication could worsen the symptoms or the course of GERD.

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Prevalence of Helicobacter Pylori Infection and Stress, Anxiety or Depression in Functional Dyspepsia and Outcome after Appropriate Intervention

Abstract: Introduction:The association between psychological factors and non-ulcer dyspepsia remains controversial.

Cited by 17 publications

References 29 publications

The effect of Helicobacter pylori eradication on functional dyspepsia in Turkish children

The effect of Helicobacter pylori eradication on functional dyspepsia in Turkish children

The Psychotic Impact of Helicobacter pylori Gastritis and Functional Dyspepsia on Depression: A Systematic Review

Helicobacter pylori and nonmalignant upper gastrointestinal diseases

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