Prevalence of Helicobacter pylori prevalence and upper gastrointestinal endoscopy in HIV/AIDS patients with gastrointestinal symptoms in the University Teaching Hospitals in Cameroon

Andoulo, Firmin Ankouane; Kowo, Mathurin; Ngatcha, Ghislaine; Ndam, Antonin Ndjitoyap; Awouoyiegnigni, Benjamin; Sida, M. Biwole; Tzeuton, Christian; Ndam, Élie Claude Ndjitoyap

doi:10.1684/mst.2016.0582

Cited by 4 publications

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“…We found no relationship between H. pylori seropositivity and HIV status. This was in line with a previous study conducted at a teaching hospital in Cameroon, which found no relationship between HIV seropositivity and H. pylori infection rates [20]. None of the associated symptoms including nausea, vomiting, belching, postprandial fullness/early satiety, acid regurgitation and heartburn predicted H. pylori seropositivity in our study population.…”

Section: Discussionsupporting

confidence: 92%

“…Additionally, Ankouane and colleagues found prevalence rates of 71.2% among patients with atrophic gastritis, 75% among those with follicular gastritis, and 80% among those with intestinal metaplasia [19]. Among HIV patients presenting with gastro-intestinal symptoms, the prevalence of H. pylori infection was 50% [20]. A population-based study carried out in two health districts in Cameroon among asymptomatic children (0–10 years) reported a prevalence of 52.3% for stool H. pylori antigen, suggesting that infection in our population is acquired at a very early ages [21].…”

Section: Introductionmentioning

confidence: 99%

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Helicobacter pylori infection among patients presenting with dyspepsia at a primary care setting in Cameroon: seroprevalence, five-year trend and predictors

Aminde

Dedino²,

Ngwasiri

et al. 2019

BMC Infect Dis

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BackgroundAlmost half the world’s population is infected with Helicobacter pylori (H. pylori) with the highest reported prevalence from Africa. This infection is associated with several morbid gastrointestinal conditions. Understanding the trends in seroprevalence and the factors associated with H. pylori seropositivity in dyspeptic persons can provide a guide for public health policies.MethodsThis was a retrospective study, carried out with outpatient records of Wum District Hospital (WDH) from January 2012 to December 2016. We reviewed records of all patients for whom a H. pylori serology test was requested. The Cochran-Armitage trend test and multiple regression models were used to explore seroprevalence trends and predictors of seropositivity respectively.ResultsWe included 451 records, 63.6% (n = 287) were female. The mean age of the study population was 40.7 years, and the overall H. pylori seroprevalence was 51.5% (95% CI: 47–56%). The use of recommended eradication regimen appears to be low and declining. On average, H. pylori seroprevalence declined by 6.8% annually (p < 0.0001). Occupational status independently predicted seropositivity, with students having lower odds of being seropositive than employed persons (aOR = 0.09, 95% CI: 0.02–0.49, p = 0.016).ConclusionDespite decreasing trends, the seroprevalence of Helicobacter pylori infection is high in dyspeptic patients attending this primary care setting. Improving living standards and establishing national guidelines for eradication can possibly aid the control of this infection.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection among patients presenting with dyspepsia at a primary care setting in Cameroon: seroprevalence, five-year trend and predictors

Aminde

Dedino²,

Ngwasiri

et al. 2019

BMC Infect Dis

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“…This may provide some level of protection against ongoing viral replication. (ii) It is also reported that H pylori infection was signi cantly associated with decreased markers of immune activation CD4+T cells, cell proliferation among ART naïve patients and HIV-negative individuals in comparison to the HIV+ H pylori-negative participants [35]. Decrease the activation of CD4+T cells with H. pylori might accelerate the differentiation of naïve CD4+T cells into memory cells, leading to thereplenishment of naïve CD4+T cells subset and restoration of CD4+TCR diversity.…”

Section: Discussionmentioning

confidence: 94%

“…This study's ndings of higher CD4+counts and lower viral loads could also be due to the following reasons. (i) H. pylori induces T regulatory cells in the GALT by secreting anti-in ammatory cytokines that may prevent in ammation of the intestinal lining by reducing immune activation [34], thus balancing over activity and immunosuppression [35]. In the context of H. pylori/HIV co-infection, circulating T regulatory cells induced by H pylori may reduce peripheral T cell activation.…”

Section: Discussionmentioning

confidence: 99%

Effect of H.pylori Infection on CD4+T Cell Count and Hiv Viral Load Among Art and Naïve Art Hiv Patients in Mekelle City, Tigray, Northern Ethiopia

Abadi

Teklu

Wondmagegn

et al. 2022

Preprint

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Background A lower CD4 + T cell count and a higher viral load are associated with acquired immunodeficiency syndrome (AIDS). The co-infection of Helicobacter pylori (H. pylori) in HIV-positive patients may affect immune parameters of HIV-related disease progression. The purpose of this study is to assess the effects of H. pylori co-infection on CD4 + T cell counts and HIV viral loads among HIV patients who are receiving ART (antiretroviral therapy) and HIV patients without ART Method A comparative cross-sectional study was conducted on 264 individuals from June to September 2020 in Mekelle city, Tigray, northern Ethiopia. A mixed sampling technique was used. H. pylori was detected using stool antigen test; CD4 + T cell count was performed by the BD FACSPrestoTM Cartridge test; and viral load was analyzed by COBAS® AmpliPrep/COBAS® TaqMan® HIV-1. The data was entered using EPi-data and analyzed using SPSS V.20 and graph pad prism software V.8. To assess the association, a one-way ANOVA, Mann Whitney test, and logistic regression were used. Result The study included 264 participants. A significant increase in CD4 + T cells was observed among ART-exposed participants with H pylori, compared with participants without H pylori with a mean ± SD of (487.5 ± 213.5 versus 395.9 ± 199.6, p = 0.004), and a decrease was observed among HIV negative controls (487.5 ± 213.5 versus 869.4 ± 123.9, P < 0.001). In ART-Naïve participants with H pylori, CD4 + T cell counts were significantly higher than in controls without H pylori (239.7 versus 115.1, P = 0.001) and considerably lower than in controls without H pylori (869.4 versus 123.9, P0.001). Participants with H pylori had significantly lower viral load levels compared to those without H pylori, with a median (IQR) of 5.13 (4.14–4.52), p = 0.031, respectively. Conclusion H. pylori/HIV co-infection resulted in increased CD4 + T cell counts and lower viral loads, but larger sample sizes and longitudinal cohort studies are needed to validate these results.

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Prevalence of HIV-associated esophageal candidiasis in sub-Saharan Africa: a systematic review and meta-analysis

et al. 2020

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Background Esophageal candidiasis (OC) is a common AIDS-defining opportunistic infection. Antiretroviral therapy (ART) reduces the occurrence of OC and other opportunistic infections among persons living with HIV (PLHIV). We sought to determine and compare the prevalence of OC in the ART and pre-ART era among PLHIV in sub-Saharan Africa (SSA). Methods We searched PubMed, Embase, Web of Science, and the African Journals Online databases to select studies in English and French reporting the prevalence of HIV-associated OC in SSA from January 1980 to June 2020. Reviews, single-case reports, and case series reporting < 10 patients were excluded. A random-effect cumulative meta-analysis was performed using STATA 16.0, and trend analysis performed using GraphPad Prism 8.0. Results Thirteen eligible studies from 9 SSA countries including a total of 113,272 patients were qualitatively synthesized, and 9 studies were included in the meta-analysis. Overall pooled prevalence of HIV-associated OC was 12% (95% confidence interval (CI): 8 to 15%, I2 = 98.61%, p <. 001). The prevalence was higher in the pre-ART era compared to the ART era, but not to statistical significance (34.1% vs. 8.7%, p = 0.095). In those diagnosed by endoscopy, the prevalence was higher compared to patients diagnosed by non-endoscopic approaches, but not to statistical significance (35.1% vs. 8.4%, p = .071). The prevalence of OC significantly decreased over the study period (24 to 16%, p < .025). Conclusion The prevalence of OC among PLHIV in the ART era in SSA is decreasing. However, OC remains a common problem. Active endoscopic surveillance of symptomatic patients and further empirical studies into the microbiology, optimal antifungal treatment, and impact of OC on quality of life of PLHIV in SSA are recommended.

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Prevalence of Helicobacter pylori prevalence and upper gastrointestinal endoscopy in HIV/AIDS patients with gastrointestinal symptoms in the University Teaching Hospitals in Cameroon

Cited by 4 publications

References 0 publications

Helicobacter pylori infection among patients presenting with dyspepsia at a primary care setting in Cameroon: seroprevalence, five-year trend and predictors

Helicobacter pylori infection among patients presenting with dyspepsia at a primary care setting in Cameroon: seroprevalence, five-year trend and predictors

Effect of H.pylori Infection on CD4+T Cell Count and Hiv Viral Load Among Art and Naïve Art Hiv Patients in Mekelle City, Tigray, Northern Ethiopia

Prevalence of HIV-associated esophageal candidiasis in sub-Saharan Africa: a systematic review and meta-analysis

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