Prevalence of Hepatitis B among Pregnant Women and Its Impact on Pregnancy and Newborn Complications at a Tertiary Hospital in the Eastern Part of Germany

Lobstein, Simon; Faber, R.; Tillmann, Hans L.

doi:10.1159/000320455

Cited by 69 publications

(87 citation statements)

References 33 publications

(27 reference statements)

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“…Also, this prevalence varies from country to country, from one region to another region and from one group to another group in a country. [8][9][10] Prevalence of hepatitis B in pregnant woman worldwide is 1.5 to 2.5% whereas in India it varies from 0.2 to 7.7%. Prevalence of mean HBV carriers in India is 0.82% according to chatterjee et al 7 In our study prevalence rate is found to be 1.09% amongst indoor antenatal patients.…”

Section: Discussionmentioning

confidence: 99%

Study on prevalence of hepatitis B in pregnant women and its effect on maternal and fetal outcome at tertiary care centre

Mishra

Purandre

Thakur

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Hepatitis-B is caused by double stranded DNA virus. Prevalence of hepatitis B in pregnant woman worldwide is 2.5 to 1.5% whereas in India it is 2 to 7.7%.Methods: This is a retrospective study conducted at SAMC and PGI, Indore between January 2016 to December 2016. Hepatitis- B prevalence and outcome was assessed by doing routine screening of hepatitis B antigen in our indoor patients and finding out their maternal and fetal outcome.Results: Total 3567 deliveries were conducted during study period, out of them 39 were diagnosed as HbsAg positive pregnant patient; so, prevalence was found to be 1.09%. out of these, 84.6% were booked cases, mode of delivery was vaginal in 66.67% cases, preterm Delivery was in 10.26% of cases, meconium stained liquor was found in 5.13% cases, maternal mortality was nil, perinatal mortality was found in 2.56% cases and 5.13% cases were admitted in NICU.Conclusions: Screening of all pregnant women for HbsAg irrespective of risk factors will definitely help to know the correct prevalence and reduce the transmission of hepatitis B infection. Hepatitis B is a major public health problem in India and will continue to be until appropriate nationwide vaccination programs and other control measures are established.

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Section: Discussionmentioning

confidence: 99%

Study on prevalence of hepatitis B in pregnant women and its effect on maternal and fetal outcome at tertiary care centre

Mishra

Purandre

Thakur

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…But some of the other studies denied these effects and believed that there is a low risk of the transmission of hepatitis B through the placenta, indicating these pregnancies are the same as non-infected pregnancies (17,23,28,31).…”

Section: Discussionmentioning

confidence: 99%

“…For quality assessment, we used the modified version of STROBE (17) which includes seven items of STROBE checklist (setting, participation, variables, bias, limitation and interpretation).There were eight low-risk studies and ten high-risk studies (5,(17)(18)(19)(20)(21)(22)(23)(24)(25) among the included studies (Figure 1). …”

Section: Methodological Quality Assessment Of the Included Studiesmentioning

confidence: 99%

Maternal Inactive Hepatitis B Status and Birth-Outcomes: A Systematic Review and Meta-Analysis

Ebrahimi

Keramat

Yunesian

et al. 2016

Iran Red Crescent Med J

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Context: Hepatitis is a term used to describe any type of hepatitis inflammation. Screening for the virus antigen during pregnancy is mandatory in some parts of the world and is recommended in others. so that, most women are aware of and understand the disease if they have it when they are pregnant. Thus, the major concerns of these women are both the virus transmission to the fetus and the effects of hepatitis B on pregnancy outcome.Evidence Acquisition: According to a specific protocol, we searched in the Pub med, Scopus, ISI web of science from 1990 to February 2015 to find the original articles, which investigated the hepatitis B effects in pregnant women with normal singleton pregnancy who were previously diagnosed with inactive CHB or were incidentally found to be HBsAg positive in routine antenatal blood test. We included any cohort, case control and cross sectional studies if they had a healthy control group and reported one or more considered maternal or prinatal outcomes in pregnant women. Meta-analysis was performed with Review manager 5.4 and Stata 11 software. We assessed the effect size that was pooled odds ratio (OR) and 95% confidence intervals (CIs) using the random effects model. We explored statistical heterogeneity using the chi-squared (Chi2), I2 and tau-squared (Tau2) statistical tests.Results: From a total of 156 identified studies, 56 studies were chosen for a detailed review, and 18 studies which met the inclusion and exclusion criteria were included in the meta analysis. Among the included studies, the outcomes were small for gestational age (SGA) large for gestational age (LGA), intra uterine growth restriction (IUGR), fetal distress, fifth minutes apgar score, first minute Apgar score, low birth weight (LBW) and Fetal Macrosomia. Conclusions:In this study, hepatitis B had a cause effect on LGA and fetal Macrosomia. Among the other considered adverse pregnancy outcomes; it didn't have any significant effect.Keywords: Hepatitis B, Neonatal Outcome, Prenatal Outcome ContextHepatitis is a term used to describe any type of hepatitis inflammation (1). Various factors such as hepatitis viruses, medicines, toxins, alcohol, etc. can lead to hepatitis. Among these, viral hepatitis is one of the main causes of premature death in humans. Babies who are born to infected mothers, intravenous drug users, persons with multiple sexual partners, frequent recipients of blood and blood products, dialysis patients and health personnel are at greater risk. Among viral hepatitis, hepatitis B has become a global problem (2). Despite the progress that has occurred in antiretroviral therapy, the number of people who die due to chronic hepatitis B infection and the number of cancer cases associated with hepatitis B, are increasing (3). It is estimated that about 2 billion people worldwide have serologic evidence of hepatitis B, of which 240 million are chronic carriers and one of which dies due to cirrhosis or hepatocellular carcinoma each year (2). The prevalence of hepatitis B carriers in the world is...

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“…Although some studies suggest that there may be an increase in the complications of pregnancy, such as gestational diabetes, antepartum hemorrhage, and preterm labor in CHB mothers (Tse et al 2005), this has not been supported by other large-scale studies Lobstein et al 2011).…”

Section: Effects Of Pregnancy On Hepatitis B Carrier Mothersmentioning

confidence: 92%

Management of Chronic Hepatitis B in Patients from Special Populations

Lai

Yuen

2015

Cold Spring Harbor Perspectives in Medicine

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Prevalence of Hepatitis B among Pregnant Women and Its Impact on Pregnancy and Newborn Complications at a Tertiary Hospital in the Eastern Part of Germany

Cited by 69 publications

References 33 publications

Study on prevalence of hepatitis B in pregnant women and its effect on maternal and fetal outcome at tertiary care centre

Study on prevalence of hepatitis B in pregnant women and its effect on maternal and fetal outcome at tertiary care centre

Maternal Inactive Hepatitis B Status and Birth-Outcomes: A Systematic Review and Meta-Analysis

Management of Chronic Hepatitis B in Patients from Special Populations

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