Prevalence of hepatitis B and hepatitis C virus infection in repeatedly transfused thalassemics in a tertiary care hospital in eastern India

Mukherjee, Kheya; Bhattacharjee, Debojyoti; Chakraborti, Goutam

doi:10.18203/2320-6012.ijrms20174596

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…The present study showed comparable results as described by Choudhury et al 2001, 19 and Mukherjee et al, 2017. 22 Furthermore anti-HCV seropositivity in our patients (51%) was comparable among multitransfused patients in Jordan (40%), 23 Egypt (45% to 76%), 24 Iran (44.7%), 25 and Pakistan (51.3%). 26 In our study, the seropositivity of HBsAg among thalassemic children was 1.5%.…”

Section: Hepatitis C Virus (Hcvsupporting

confidence: 60%

“…Our result was comparable to a study in India, where the prevalence rate of HBsAg was ranged from 1.2–7.4%. 22 However, the prevalence rate is still high compared to other Asian countries, such as Turkey and Malaysia, which reported lower HBsAg seroprevalence rates of 0.75% and 1%, respectively. 27 , 28 Differences in the prevalence of TTIs amongst thalassemic could be related to geographical differences in the prevalence of the viral infections among blood donors, the nature of blood donors, whether replacement or voluntary and most important the nature of care individual thalassemics receives.…”

Section: Discussionmentioning

confidence: 94%

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A Seroprevalence of Hbv, HCV and Hiv-1 and Correlation With Molecular Markers Among Multi-Transfused Thalassemia Patients in Western India

Mishra¹,

Shah²,

Patel³

et al. 2020

Mediterr J Hematol Infect Dis

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Background: Blood transfusion is a lifesaving therapy for patients with hemoglobinopathies. However, the need of frequent transfusion carries the risk of transfusion-transmitted infections (TTIs). This study was aimed to determine the seroprevalence of Hep-B, Hep-C and HIV-1infections among the multi-transfused Beta-thalassemic patients and correlate the same with NAT testing. Methods: Total 196 patients with Beta-thalassemia were included in the study. Patients were screened for the presence of viral markers by third generation ELISA test as well as for viral DNA/RNA by NAT. Results: Among these 196 multi-transfused Beta-thalassemia patients, 32.1% were females and 67.8% were males. A total of 100 (51.1%) patients were found to be anti-HCV antibody reactive, while HCV-RNA was positive in 66 (33.7 %) of the 196 patients tested. There were 6 (3.1%) patients reactive for anti-HIV-1 antibody, while 8 (4.1%) were positive for HIV-RNA. There were only 3 (1.5%) patients that were found to be reactive for HBsAg, however 5 (2.5%) were positive for HBV-DNA. Two (1%) patients had co-infection of anti-HCV antibody and HBsAg,whereas 6 patients were found co-infected by NAT testing, in-which 3 (1.5%) were positive for HBV-DNA and HCV-RNA, 1 (0.5%) was positive for HIV-RNA and HBV-DNA, and 2 (1%) had co-infection of HIV-RNA and HCV RNA. Conclusion: Prevalence of HCV among multi-transfused Beta-thalassemia patients is significantly higher than the normal population. On the other hand, the study showed low prevalence of HBV. Therefore, a follow-up schedule and administration of booster dose of HBV vaccine is strongly recommended for thalassemia patients. To the best of our knowledge, this is the foremost work that shows prevalence of HIV, HBV and HCV in thalassemia patients using both serology and molecular markers in Western India.

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Section: Hepatitis C Virus (Hcvsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 94%

A Seroprevalence of Hbv, HCV and Hiv-1 and Correlation With Molecular Markers Among Multi-Transfused Thalassemia Patients in Western India

Mishra¹,

Shah²,

Patel³

et al. 2020

Mediterr J Hematol Infect Dis

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“…When compared to statistics available through peer-reviewed studies from India,[ 15 16 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 ] incidence of HIV-1, HBV and HCV in our thalassemia cohort was on the higher side [ Table 7 ]. Most recent reports from our country document the high prevalence of these TTIs due to the use of molecular tests in addition to serological tests like in our study [ Table 7 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of HIV, hepatitis B and hepatitis C infections among patients with thalassemia attending a tertiary care (rural) hospital

Mandal,

Sarkar,

Haldar

et al. 2024

Journal of Family Medicine and Primary Care

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Introduction: The Sunderban area of West Bengal is home to tribal and religious minorities inhabiting various islands. There is a high prevalence of thalassemia among poverty-stricken residents of this region living with meagre health care facilities. This work was planned to determine the proportion of four viral transfusion-transmitted infections (TTIs): HIV-1, HIV-2, hepatitis B virus (HBV) and hepatitis C virus (HCV) among thalassemia patients attending the sole rural medical college in the region. Materials and Methods: Thalassemia patients (n = 359, age ranging from 1 year to 60 years) attending the thalassemia clinic or being admitted to the indoor facilities for better management were included in the study. Only patients diagnosed with high-performance liquid chromatography (HPLC) and with classical clinical features were included in the study. Blood samples of these patients were tested for HIV as per NACO protocol. For HBV and HCV, samples were first tested serologically; reactive samples were collected and sent in the cold chain to a higher centre for nucleic acid amplification testing (NAAT) for qualitative and quantitative estimation. Clinical and laboratory data was collected, patients were followed up for complications and hospitalisation during the study period, and statistical analysis was performed. Results: Majority of our patients had E-beta-thalassemia (245, 59.81%), followed by beta-thalassemia major (102, 28.30%). NAAT-confirmed HCV infection (14.21%) infection was the most common, followed by HBV (2.51%), and lastly by HIV-1 (0.58%) infection. Among infected thalassemia patients, the mean HCV RNA was 741063 ± 438514.67 IU/ml while the mean HBV DNA level was 4082863 ± 7298514 IU/ml. Co-infections of HIV-1 and HCV and that of HBV and HCV were noted in one patient each (0.28%). HCV-related liver disease (14.21%) and growth retardation (10.31%) were the most typical complication noted, and death occurred in five patients (1.39%) during the study period. Conclusion: Primary care physicians should know HCV infection is the most common TTI among thalassemia patients in rural eastern India.

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“…There are also contraindicating reports on the rate of prevalence in studies conducted in different parts of the world, for example, the prevalence of HCV among Egyptian, Taiwanese, Thai, Italian, Jordanian, Pakistan and eastern India thalassemia patients was reported 45.50%, 37.30%, 20.20%, 56.30%, 40.5%, 49% and 24.6%, respectively [57][58][59][60][61][62][63]. Although our overall prevalence is lower than these reports, most of the studies we have reviewed is consistent with the mentioned studies from the other countries.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence and geographical distribution of hepatitis C virus in Iranian patients with thalassemia: a systematic review and meta-analysis

Shamshirian

Alizadeh‐Navaei

Pourfathollah

et al. 2019

Journal of Laboratory Medicine

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Abstract Background Thalassemia as a hereditary hemoglobinopathy is the most common monogenic disease worldwide. Patients with thalassemia require regular blood transfusion, which provides the risk for the transmission of hepatitis C virus (HCV) as the most common post-transfusion infection in such patients, and this rate is very diverse in different parts of the world. We aimed to determine the prevalence of HCV among patients with thalassemia in Iran. Methods In this study, we searched for articles on the prevalence of HCV among Iranian thalassemia patients in English and Persian databases up to 2017. Heterogeneities were assessed by using an I-square (I2) test. Prevalence and 95% confidence interval (CI) were calculated using the random effects model. Results In total, 37 studies with 9185 patients were included in the meta-analysis. The prevalence of HCV among Iranian thalassemia patients was 17.0% (95% CI: 14.5–19.8). The rate of prevalence among male and female subjects was 17.4% (95% CI: 13.8–21.9) and 16.8% (95% CI: 13.2–21.1), respectively. Conclusions We found that the prevalence of HCV among Iranian thalassemia patients declined over time and the Iranian Blood Transfusion Organization has had a reasonable performance in HCV screening.

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Prevalence of hepatitis B and hepatitis C virus infection in repeatedly transfused thalassemics in a tertiary care hospital in eastern India

Cited by 7 publications

References 14 publications

A Seroprevalence of Hbv, HCV and Hiv-1 and Correlation With Molecular Markers Among Multi-Transfused Thalassemia Patients in Western India

A Seroprevalence of Hbv, HCV and Hiv-1 and Correlation With Molecular Markers Among Multi-Transfused Thalassemia Patients in Western India

Prevalence of HIV, hepatitis B and hepatitis C infections among patients with thalassemia attending a tertiary care (rural) hospital

Seroprevalence and geographical distribution of hepatitis C virus in Iranian patients with thalassemia: a systematic review and meta-analysis

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